The effect of feedback and information on children's pedometer step counts at school

This study examined whether feedback or feedback plus physical activity information could increase the number of pedometer steps taken during 1 school week. One hundred seventy-seven students (mean age 9.124 ± 1.11 years) in three elementary schools participated. Schools were randomly assigned to control (CON), feedback (FB), or feedback plus information (FB+I) groups. Children wore pedometers during school time for 5 consecutive weekdays. The total steps of the groups were recorded at the end of each school day, with students in the FB and FB+I groups free to view their step counts. In addition, the FB+I group received information and ideas about how they could increase their daily steps. The CON group received no step-count feedback or information. Students in the FB+I group achieved significantly more steps per minute (17.17 ± 4.87) than those in the FB (13.77 ± 4.06, p = 0.003) and CON (12.41 ± 3.12, p = 0.0001) groups. Information, as well as step-count feedback, increased elementary students’ school-based physical activity (number of steps) in the short term. A longer intervention period is necessary to assess the sustained impact of this type of approach

Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody.

L-selectin is a lectin-like receptor that mediates the attachment of lymphocytes to high endothelial venules (HEV) of lymph nodes during the process of lymphocyte recirculation. Two sulfated, mucin-like glycoproteins known as Sgp50/GlyCAM-1 and Sgp90/CD34 have previously been identified as HEV-associated ligands for L-selectin. These proteins were originally detected with an L-selectin/Ig chimera called LEC-IgG. GlyCAM-1 and CD34 are also recognized by an antiperipheral node addressin (PNAd) mAb called MECA 79, which blocks L-selectin-dependent adhesion and selectively stains lymph node HEV. The present study compares the requirements for the binding of MECA 79 and LEC-IgG to HEV-ligands. Whereas desialylation of GlyCAM-1 and CD34 drastically reduced binding to LEC-IgG, this treatment enhanced the binding of GlyCAM-1 to MECA 79. In contrast, the binding of both MECA 79 and LEC-IgG to GlyCAM-1 and CD34 was greatly decreased when the sulfation of these ligands was reduced with chlorate, a metabolic inhibitor of sulfation. Because MECA 79 stains HEV-like vessels at various sites of inflammation, recognition by L-selectin of ligands outside of secondary lymphoid organs may depend on sulfation. In addition to their reactivity with GlyCAM-1 and CD34, both MECA 79 and LEC-IgG recognize an independent molecule of approximately 200 kD in a sulfate-dependent manner. Thus, this molecule, which we designate Sgp200, is an additional ligand for L-selectin

‘The voice is the guide to the experience as well as the experience itself’: An interview with non zero one

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Since 2009, non zero one – a London-based collective of artists with a background and interest in theatre but working across media and performance disciplines – has devised a series of unexpected, challenging but also light-hearted and inviting experiences of immersion. Whilst embracing a variety of techniques and contemporary media, one of the key features of the company’s work is the exploration of audience interaction through the use of headphones, typically in promenade and/or site-specific performance contexts. Following a first section that questions the role of voice in (theatrical) sonic immersion, the text unfolds as a dialogue between practitioner-scholar Konstantinos Thomaidis and non zero one artist and theatre director Sarah Butcher. The interview lends an attentive ear to the role of voice in the company’s work, from pre-recorded instruction to live audio interaction

Enrichment of innate lymphoid cell populations in gingival tissue

Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual subsets of ILCs in the oral tissues. We sought to investigate the whole ILC population (group 1, 2, and 3 subsets) in the murine gingivae and the lymph nodes draining the oral cavity. We show that ILCs made up a greater proportion of the whole CD45+ lymphocyte population in the murine gingivae (0.356% ± 0.039%) as compared with the proportion of ILCs in the draining lymph nodes (0.158% ± 0.005%). Cytokine profiling of the ILC populations demonstrated different proportions of ILC subsets in the murine gingivae versus the regional lymph nodes. The majority of ILCs in the draining lymph nodes expressed IL-5, whereas there were equal proportions of IFN-γ- and IL-5 expressing ILCs in the oral mucosa. The percentage of IL-17+ ILCs was comparable between the murine gingivae and the oral draining lymph nodes. These data suggest an enrichment of ILCs in the murine gingivae, and these ILCs reflect a cytokine profile discrepant to that of the local draining lymph nodes. These studies indicate diversity and enrichment of ILCs at the oral mucosal surface. The function of ILCs in the oral cavity remains to be determined; here, we provide a premise of ILC populations that merits future consideration in investigations of mouse models and human tissues

Evidence for Recent Wet-Based Crater Glaciation in Tempe Terra, Mars.

[Introduction] Mars’ mid-latitudes host abundant putative debris-covered water-ice glaciers (viscous flow features; VFF). Eskers emerging from 110-150 Myr-old VFF in Phlegra Montes and Tempe Terra provide evidence for rare occurences of past, localized basal melting of their parent VFF, despite the cold climates of the late Amazonian (see this conf.). Eskers are sinuous ridges comprising glaciofluvial sediment deposited by meltwater flowing through tunnels within glacial ice. Here, we describe a population of sinuous ridges emerging from VFF in an unnamed ~45 km-diameter crater (38.47 N, 72.43 W) in Tempe Terra, ~600 km from the VFF-linked esker identified by Butcher et al. We consider two working hypotheses for the formation of the sinuous ridges; that they are either (1) eskers formed by melting of the glaciers from which they emerge, or (2) topographically inverted fluvial channels which formed prior to glaciation of the crater. We present observations from preliminary geomorphic mapping of the crater to start to test those hypotheses

Highly erosive glaciers on Mars - the role of water

International audiencePolewards of 30 • in each hemisphere, the surface of Mars hosts a suite of landforms reminiscent of glacial landscapes on Earth. Amongst these landforms are: 1) Viscous Flow Features (VFF), which resemble glaciers on Earth and are thought to contain large volumes of water ice, 2) martian gullies which are km-scale features resembling water-eroded gullies on Earth and 3) arcuate ridges thought to be moraines from previous glaciations. Gullies have been long-associated with a surface unit originally called "pasted-on terrain" and now often called the "latitude dependant mantle". Arcuate ridges are often found at the base of hillslopes with gullies, but are also found on hillslopes with pasted-on terrain and no gullies. We have found a systematic lowering of the slope of the bedrock exposure located topographically above the pasted-on terrain whether that same slope hosts gullies or not. The lowered bedrock exposures display a different surface texture from bedrock exposed on other parts of the crater wall and from fresh crater walls-it appears fragmented and has reduced relief. Using 1-m-digital elevation models from the High Resolution Imaging Science Experiment (HiRISE) we compared the slopes of eight "eroded" craters and seven unmodified craters. We estimated their age using the crater size-frequency distribution of small craters on their ejecta blankets. From this information we calculated bedrock retreat rates for the eroded craters and found they were up to ∼103 m Myr-1-equivalent to erosion rates of wet-based glaciers on Earth. This is several orders of magnitude higher than previous estimates of erosion by VFF (10-2-101 m Myr-1), which themselves are roughly equivalent to cold-based glaciers on Earth. Such erosion rates are sufficient to erase previously existing landforms, such as martian gullies. We hypothesise, therefore, that the pasted-on terrain is a glacial deposit, overturning its previous interpretation as an airfall deposit of ice nucleated on dust. We maintain the interpretation of the arcuate ridges as moraines, but further conclude that they are likely the result of glaciotectonic deformation of sub-marginal and proglacial sediment in the presence of sediment pore-water. We do not support the generation of large quantities of glacial meltwater because it would have broken-up and degraded the arcuate ridges and pasted-on terrain an produced a suite of landforms (e.g., hummocky moraine, lacustrine forms, outwash plains, eskers) which are not observed

The living aortic valve: From molecules to function.

The aortic valve lies in a unique hemodynamic environment, one characterized by a range of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and direction throughout the cardiac cycle. Yet, despite its changing environment, the aortic valve opens and closes over 100,000 times a day and, in the majority of human beings, will function normally over a lifespan of 70-90 years. Until relatively recently heart valves were considered passive structures that play no active role in the functioning of a valve, or in the maintenance of its integrity and durability. However, through clinical experience and basic research the aortic valve can now be characterized as a living, dynamic organ with the capacity to adapt to its complex mechanical and biomechanical environment through active and passive communication between its constituent parts. The clinical relevance of a living valve substitute in patients requiring aortic valve replacement has been confirmed. This highlights the importance of using tissue engineering to develop heart valve substitutes containing living cells which have the ability to assume the complex functioning of the native valve

Using Wave-Packet Interferometry to Monitor the External Vibrational Control of Electronic Excitation Transfer

We investigate the control of electronic energy transfer in molecular dimers through the preparation of specific vibrational coherences prior to electronic excitation, and its observation by nonlinear wave-packet interferometry. Laser-driven coherent nuclear motion can affect the instantaneous resonance between site-excited electronic states and thereby influence short-time electronic excitation transfer (EET). We first illustrate this control mechanism with calculations on a dimer whose constituent monomers undergo harmonic vibrations. We then consider the use of nonlinear wave-packet interferometry (nl-WPI) experiments to monitor the nuclear dynamics accompanying EET in general dimer complexes following impulsive vibrational excitation by a sub-resonant control pulse (or control pulse sequence). In measurements of this kind, two pairs of polarized phase-related femtosecond pulses following the control pulse generate superpositions of coherent nuclear wave packets in optically accessible electronic states. Interference contributions to the time- and frequency-integrated fluorescence signal due to overlaps among the superposed wave packets provide amplitude-level information on the nuclear and electronic dynamics. We derive the basic expression for a control-pulse-dependent nl-WPI signal. The electronic transition moments of the constituent monomers are assumed to have a fixed relative orientation, while the overall orientation of the complex is distributed isotropically. We include the limiting case of coincident arrival by pulses within each phase-related pair in which control-influenced nl-WPI reduces to a fluorescence-detected pump-probe difference experiment. Numerical calculations of pump-probe signals based on these theoretical expressions are presented in the following paper