ETICA Workshop on Computer Ethics: Exploring Normative Issues

The ETICA project aims to identify emerging information and communication technologies. These technologies are then analysed and evaluated from an ethical perspective. The aim of this analysis is to suggest possible governance arrangements that will allow paying proactive attention to such ethical issues. During the ETICA workshop at the summer school, participants were asked to choose one of the 11 technologies that ETICA had identified. For each of these technologies there was a detailed description developed by work package 1 of the project. Workshop participants were asked to reflect on the ethical issues they saw as relevant and likely to arise from the technology. This paper discusses the ethical views of the workshop participants and contrasts them with the findings of the ethical analysis within the ETICA project

Splenectomy Normalizes Hematocrit in Murine Polycythemia Vera

Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2V617) induces splenomegaly and an increase in hematocrit. Splenectomy is sparingly performed in patients with PV, however, due to surgical complications. Thus, the role of the spleen in the pathogenesis of human PV remains unknown. We specifically tested the role of the spleen in the pathogenesis of PV by performing either sham (SH) or splenectomy (SPL) surgeries in a murine model of JAK2V617F-driven PV. Compared to SH-operated mice, which rapidly develop high hematocrits after JAK2V617F transplantation, SPL mice completely fail to develop this phenotype. Disease burden (JAK2V617) is equivalent in the bone marrow of SH and SPL mice, however, and both groups develop fibrosis and osteosclerosis. If SPL is performed after PV is established, hematocrit rapidly declines to normal even though myelofibrosis and osteosclerosis again develop independently in the bone marrow. In contrast, SPL only blunts hematocrit elevation in secondary, erythropoietin-induced polycythemia. We conclude that the spleen is required for an elevated hematocrit in murine, JAK2V617F-driven PV, and propose that this phenotype of PV may require a specific interaction between mutant cells and the spleen

What future, which technology? On the problem of describing relevant futures.

Doing research on future and emerging technologies raises a number of significant ontological and epistemological challenges. The fundamental uncertainty of the future, combined with problems of appropriate descriptions of technology in general, render it difficult to come to an appropriate account of the likely shape and use of future technologies. This paper discusses several streams of research that address this issue, including the question of relevant description and context, interpretive flexibility, affordances of technology, and multi-stability of technological trajectories. The paper proposes that some of these problems may be addressed by using a democratic and participative approach to technology research and development. Participative technology assessment is then discussed as an example of an established way of democratically engaging with technology stakeholders during research and development. The paper concludes by discussing the promises and limitations of such a participative approach with regard to the question of understanding and researching future technologies

Humic-like substances from agro-industrial residues affect growth and nitrogen assimilation in maize (Zea mays L.) plants

Humic-like substances (HL) extracted from the agro-industrial residues of rape (Brassica napus) (B-HL), castor-oil (Ricinus communis) (R-HL) and flax (Linum usitatissimum) (L-HL), and from a digestate (D-HL) were analyzed for their elemental composition and characterized by FT-IR and 13CNMR spectroscopy. The indoleacetic acid (IAA), total phenol (TP) and flavonoid (FL) content, and their auxin-like activity were also determined. HL were then applied to maize plantlets in order to evaluate their effect on plant growth, nitrogen metabolism, and photosynthesis. Results showed that all the HL had a physiologically active IAA, TP and FL content. HL positively affected the growth of maize with a noticeable increase in leaf biomass. The HL from digestate showed the highest values of glutamine synthethase and glutamate synthase enzyme activity, whereas both L and B-HL were more efficient in affecting the chlorophyll a, b and total carotene content. In conclusion, the biostimulant activity of the four HL varied, but the greater bioactivity of HL from digestate was a result of its high acidity and carbon distribution together with its high IAA and TP content, and high auxin-like activit

What does the future hold? A critical view of emerging information and communication technologies and their social consequences.

This paper provides an overview of emerging information and communication technologies (ICTs) that can be expected to become socially relevant in the next 10 to 15 years. It describes the results of a dual discourse analysis of publiccations on emerging ICTs. Sources were, on the one hand, government/policy publications and, on the other, publications by research institutions. This discourse analysis led to the identification of 11 emerging ICTs. For each of these ICTs, defining features were collected. In order to gain a larger scale understanding, the defining features were then regrouped to assess which likely effect they might have on the relationship between humans and their environment. These features are then interpreted and investigated with regard to what they betray about the implied assumptions about individuals, society and technology. The paper ends by critically reflecting the chosen approach and asking how this research can help us develop technology in desirable ways

Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)

<p>Abstract</p> <p>Background</p> <p>Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma.</p> <p>Methods</p> <p>A single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thickness > 1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009. Head and neck melanoma were excluded. SLN was identified following preoperative lymphoscintigraphy and intraoperative gamma probe interrogation.</p> <p>Results</p> <p>The SLN identification rate was 97%. The SLN was tumor positive in 44 patients (22%). Positive SLN was significantly associated with primary tumor thickness and microscopic ulceration. The median follow-up was 39.5 (5–97) months. Disease progression was significantly more frequent in SLN positive patients (32% vs 13%, p = 0.002). Five-year DFS and OS of the entire cohort were 79.6% and 84.6%, respectively, with a statistical significant difference between SLN positive (58.7% and 69.7%) and SLN negative (85% and 90.3%) patients (p = 0.0006 and p = 0.0096 respectively). Postoperative complications after SLNB were observed in 12% of patients.</p> <p>Conclusion</p> <p>Our data confirm previous studies and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the benefit of additional CLND in patients with positive SLN remains to be demonstrated.</p