Real pinor bundles and real Lipschitz structures

We obtain the topological obstructions to existence of a bundle of irreducible real Clifford modules over a pseudo-Riemannian manifold $(M,g)$ of arbitrary dimension and signature and prove that bundles of Clifford modules are associated to so-called real Lipschitz structures. The latter give a generalization of spin structures based on certain groups which we call real Lipschitz groups. In the fiberwise-irreducible case, we classify the latter in all dimensions and signatures. As a simple application, we show that the supersymmetry generator of eleven-dimensional supergravity in "mostly plus" signature can be interpreted as a global section of a bundle of irreducible Clifford modules if and $\textit{only if}$ the underlying eleven-manifold is orientable and spin.Comment: 94 pages, various tables and diagram

Provably safe cruise control of vehicular platoons

We synthesize performance-aware safe cruise control policies for longitudinal motion of platoons of autonomous vehicles. Using set-invariance theories, we guarantee infinite-time collision avoidance in the presence of bounded additive disturbances, while ensuring that the length and the cruise speed of the platoon are bounded within specified ranges. We propose: 1) a centralized control policy and 2) a distributed control policy, where each vehicle's control decision depends solely on its relative kinematics with respect to the platoon leader. Numerical examples are included.NSF; CPS-1446151; CMMI-1400167; FA 9550-15-1-0186 - AFOSR; Schlumberger Foundation Faculty for the Future Fellowship; FA 9550-15-1-0186 - AFOSR; NSF; ECCS-1550016; CNS 123922

A role for recurrent processing in object completion: neurophysiological, psychophysical and computational"evidence

Recognition of objects from partial information presents a significant challenge for theories of vision because it requires spatial integration and extrapolation from prior knowledge. We combined neurophysiological recordings in human cortex with psychophysical measurements and computational modeling to investigate the mechanisms involved in object completion. We recorded intracranial field potentials from 1,699 electrodes in 18 epilepsy patients to measure the timing and selectivity of responses along human visual cortex to whole and partial objects. Responses along the ventral visual stream remained selective despite showing only 9-25% of the object. However, these visually selective signals emerged ~100 ms later for partial versus whole objects. The processing delays were particularly pronounced in higher visual areas within the ventral stream, suggesting the involvement of additional recurrent processing. In separate psychophysics experiments, disrupting this recurrent computation with a backward mask at ~75ms significantly impaired recognition of partial, but not whole, objects. Additionally, computational modeling shows that the performance of a purely bottom-up architecture is impaired by heavy occlusion and that this effect can be partially rescued via the incorporation of top-down connections. These results provide spatiotemporal constraints on theories of object recognition that involve recurrent processing to recognize objects from partial information

MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer.

A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus. Genomic studies implicate this locus in the initiation of clinically significant PCa and with progression to metastatic disease. However, the genes within this region have not been fully characterized to date. Here we demonstrate for the first time that a microRNA component of this region-miR-383-is frequently downregulated in prostate cancer, has a critical role in determining tumor-initiating potential and is involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells. Expression analyses of miR-383 in PCa clinical tissues established that low miR-383 expression is associated with poor prognosis. Functional data suggest that miR-383 regulates PCa tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR-383 inhibited tumor-initiating capacity of CD44+ PCa cells. Also, 'anti-metastatic' effects of ectopic miR-383 expression were observed in a PCa experimental metastasis model. In view of our results, we propose that frequent loss of miR-383 at chr8p22 region leads to tumor initiation and prostate cancer metastasis. Thus, we have identified a novel finding that associates a long observed genomic alteration to PCa stemness and metastasis. Our data suggest that restoration of miR-383 expression may be an effective therapeutic modality against PCa. Importantly, we identified miR-383 as a novel PCa tissue diagnostic biomarker with a potential that outperforms that of serum PSA

Expression, Tissue Distribution and Function of miR-21 in Esophageal Squamous Cell Carcinoma

Objective:MiR-21 is an oncomir expressed by malignant cells and/or tumor microenvironment components. In this study we focused on understanding the effects of stromal miR-21 on esophageal malignant cells.Design:MiR-21 expression was evaluated in formalin-fixed paraffin-embedded samples from patients with esophageal squamous-cell carcinoma (SCC) by quantitative RT-PCR. MiR-21 tissue distribution was visualized with in situ hybridization. A co-culture system of normal fibroblasts and esophageal cancer cells was used to determine the effects of fibroblasts on miR-21 expression levels, and on SCC cell migration and invasion.Results:MiR-21 was overexpressed in SCCs, when compared to the adjacent non-tumor tissues (P = 0.0007), and was mainly localized in the cytoplasm of stromal cells adjacent to malignant cells. Accordingly, miR-21 expression was increased in tumors with high versus low stromal content (P = 0.04). When co-cultured with normal fibroblasts, miR-21 expression was elevated in SCC cells (KYSE-30), while its expression was restricted to fibroblasts when co-cultured with adenocarcinoma cells (OE-33 and FLO-1). MiR-21 was detected in conditioned media of cancer cell lines, illustrating the release of this miRNA into the environment. Co-culturing with normal fibroblasts or addition of fibroblast conditioned media caused a significant increase in cell migration and invasion potency of KYSE-30 cells (P<0.0001). In addition, co-culturing cancer cells with fibroblasts and expression of miR-21 induced the expression of the cancer associated fibroblast (CAF) marker S100A4.Conclusions:MiR-21 expression is mostly confined to the SCC stroma and its release from fibroblasts influences the migration and invasion capacity of SCC cells. Moreover, miR-21 may be an important factor in "activating" fibroblasts to CAFs. These findings provide new insights into the role of CAFs and the extracellular matrix in tumor microenvironment formation and in tumor cell maintenance, and suggest miR-21 may contribute to cellular crosstalk in the tumor microenvironment. © 2013 Nouraee et al

How mineralogy and geochemistry can improve the significance of Pb isotopes in metal provenance studies

Lead isotopes combined with trace element data represent a powerful tool for non-ferrous metal provenance studies. Nevertheless, unconsidered geological factors and archaeological data, as well as ignored analytical procedures, may substantially modify the interpretation of the isotopic and trace element signature obtained as a potential ore candidate. Three archaeological examples, accompanied by high-resolution lead isotopic measurements (MC–ICP–MS), are presented here to discuss the above-mentioned criticisms and to propose some solutions. The first example deals with prehistoric/historical gold/silver-mining activity from Romania (the Baia Borşa and Roşia Montană ore deposits). The second one regards the lead/silver metallurgical activity from the Mont-Lozère massif (France) during medieval times. The third example focuses on the comparison between two batches of lead isotope data gathered on Roman lead ingots from Saintes-Maries-de-la-Mer, using different SRM 981 Pb values

Lead isotope analyses of gold–silver ores from Roşia Montană (Romania): a first step of a metal provenance study of Roman mining activity in Alburnus Maior (Roman Dacia)

The Roşia Montană ore deposit (Apuseni Mountains, Romania) is Europe’s largest Au–Ag deposit. It also corresponds to the Roman Alburnus Maior mining site, known by historians and archaeologists due to the discovery of dozens of Roman wooden wax tablets during the underground works carried out during the 18th and 19th centuries.The present geochemical research is based on a detailed archaeological and geological study of the Roman mines at Roşia Montană, making use of archaeologically and geologically documented ore samples. The geochemical analyses allowed us to establish an accurate database for the ores exploited during Roman times at Roşia Montană (and probably before). This approach represents a contribution towards improving the accuracy of metal provenance studies of gold–silver ores during antiquity in Romania, and also at an European level, because the studied ore samples represent remnants of the original ores used by the Romans for the production of precious metals.Twenty-nine ore samples and one litharge roll have been selected, prepared and analysed by MC-ICP-MS (high-resolution measurements). A specific Roşia Montană Pb isotope signature of gold–silver ores extracted by the Roman miners was obtained. This signature is distinct when compared with other ore deposits from the Apuseni Mountains, as well as within a broader region (Maramureş ore district).A litharge roll discovered in a Roman inclined adit situated close to the surface, which attests the presence of metallurgical workshops, has also been analysed. The different lead isotope values of the litharge roll and the Roşia Montană gold–silver ores suggest that other ore sources from the South Apuseni Mountains or from elsewhere were also employed by the gold metallurgy developed at Roşia Montană during Roman times

Al based alloys containing amorphous and nanostructured phases

Nanostructured or partially amorphous Al-based alloys are attractive candidates for advanced high-strength lightweight materials. The strength of such materials is often 2 - 3 times higher than the strength of commercial crystalline alloys. Further property improvements are achievable by designing multi-phase composite materials with optimized length scale and intrinsic properties of the constituent phases. Such alloys can be prepared by quenching from the melt or by powder metallurgy using mechanical attrition techniques. This paper focuses on mechanically attrited Al-based powders containing amorphous or nano-crystalline phases, Al-based MMCs containing metallic glass reinforcement and on their consolidation into bulk specimens. Selected examples of mechanical deformation behavior are presented, revealing that the properties can be tuned within a wide range of strength and ductility as a function of size and volume fraction of the different phases

Holomorphic potentials for graded D-branes

We discuss gauge-fixing, propagators and effective potentials for topological A-brane composites in Calabi-Yau compactifications. This allows for the construction of a holomorphic potential describing the low-energy dynamics of such systems, which generalizes the superpotentials known from the ungraded case. Upon using results of homotopy algebra, we show that the string field and low energy descriptions of the moduli space agree, and that the deformations of such backgrounds are described by a certain extended version of `off-shell Massey products' associated with flat graded superbundles. As examples, we consider a class of graded D-brane pairs of unit relative grade. Upon computing the holomorphic potential, we study their moduli space of composites. In particular, we give a general proof that such pairs can form acyclic condensates, and, for a particular case, show that another branch of their moduli space describes condensation of a two-form.Comment: 47 pages, 7 figure

A Path Integral Approach To Noncommutative Superspace

A path integral formula for the associative star-product of two superfields is proposed. It is a generalization of the Kontsevich-Cattaneo-Felder's formula for the star-product of functions of bosonic coordinates. The associativity of the star-product imposes certain conditions on the background of our sigma model. For generic background the action is not supersymmetric. The supersymmetry invariance of the action constrains the background and leads to a simple formula for the star-product.Comment: Latex 13 pages. v2: references and footnotes adde