La valutazione dell'efficacia interna di corsi universitari: l'impatto del contesto e dei legami relazionali tra gli studenti

L'obiettivo di questo lavoro è quello di fornire una panoramica su come includere gli effetti di contesto e dei legami relazionali tra gli studenti in un modello per la valutazione dell'efficacia interna di corsi universitari. In particolare, a seconda della tipologia dei dati, possono essere utilizzati diversi strumenti metodologici: un approccio basatu sui peer effects, che sviluppa l'assunzione che i comportamenti degli studenti sono influenzati da quelli dei loro pari, e un approccio basato sull'introduzione di variabili individuali legate al comportamento ed alle capacità relazionali degli studenti. Dopo una breve introduzione a questi tipi di approcci, vengono presentati i risultati di alcune applicazioni empiriche condotte sugli studenti di un Corso di laurea magistrale dell'università di Roma “Tor Vergata”. L'evidenza empirica suggerisce che sia gli effetti di contesto, sia le caratteristiche relazionali degli studenti sono predittori significativi del rendimento universitario individuale.This paper is aimed at providing an overview on how to include contextual effects and relational ties between students in a model for the evaluation of the internal effectiveness of a degree course. In particular, depending on the type of available data, different methods are proposed: an approach based on peer effects, that develops the assumption that the behaviors of students are influenced by those of their peers; and an approach based on the introduction of individual variables, related to the student relational behaviors and abilities. After a brief introduction to these techniques, we present the results of some empirical applications, conducted on the students of a second level degree course of the university of Rome Tor Vergata. Empirical evidence suggests that both contextual effects and student relational features are significant predictors of individual academic achievement

Informatização do Processo de Trâmite de Publicações - InfoCLP.

Projeto/Plano de Ação: 11.11.11.111

Estruturação da vigilância epidemiológica e manejo populacional de suídeos asselvajados (Sus scrofa) para área livre de peste suína clássica do Brasil.

Suplemento 2, ref. 30. Edição dos Resumos do 3 Encontro Nacional de Defesa Sanitária Animal, Foz de Iguaçu, dez. 2013

Management of chronic myeloid leukaemia patients treated with ponatinib in a real-life setting: A retrospective analysis from the monitoring registries of the Italian Medicines Agency (AIFA)

Real-world data on daily practice management, treatment modifications and outcome of a large cohort of chronic myeloid leukaemia (CML) patients treated with ponatinib was performed through monitoring Registries of the Italian Medicines Agency (AIFA). Overall, 666 CML subjects were included in the ponatinib registry from February 2015 to December 2020 and were eligible for analysis: 515 in chronic phase (CP), 50 in accelerated phase (AP) and 101 in blast crisis (BC). Median age at baseline was 58.7 years with a predominance of male subjects (57.1%). The median time from diagnosis to start of ponatinib was 2.35 years: 259 (38.9%) subjects had received two previous lines of treatment, 260 (39.0%) three lines and 147 (22.1%) four or more lines. A molecular response [from major molecular response (MMR) to a score of ≤0.01% on the international reporting scale (IS)] was reported for 59% of patients out of 593 patients analysed. With a median follow-up of 14.4 months, 136 subjects (20.4%) required at least one dose reduction due to adverse events (AEs), whereas 309 patients (46.4%) required dose reduction in the absence of any evidence of side effects. Treatment discontinuation occurred in 261 patients (39%). This real-life analysis shows that dose reductions were made primarily as a precaution rather than due to the occurrence of adverse reactions

The impact of starting dose on overall survival in myelofibrosis patients treated with ruxolitinib: A prospective real-world study on AIFA monitoring registries

Ruxolitinib is a JAK1/JAK2 inhibitor approved for the treatment of myelofibrosis (MF)-related splenomegaly or symptoms. The recommended starting dose depends on platelet count, regardless of haemoglobin level at baseline. In the recent years, an overall survival (OS) advantage was reported in patients treated with ruxolitinib compared with best available therapy. We analysed a large Italian cohort of 3494 patients identified by Agenzia Italiana del Farmaco (AIFA) monitoring registries. Of them, 2337 (66.9%) started at reduced dose: these patients were older (median age 70 vs. 67), with increased incidence of large splenomegaly (longitudinal diameter 20 vs. 19.1 cm, median volume 1064 cm3 vs. 1016 cm3), with higher IPSS risk (30.9% vs. 26.1%), and worse ECOG score (more than 1 in 14.3% vs. 9.8%). After balancing for baseline characteristics, Kaplan–Meier analysis showed a median OS of 78.2 months (95% CI 65.9–89) for patients who started at full dose and 52.6 (95% CI 49–56.6) months for patients who started with reduced dose (p < 0.001). Group analysis also showed a substantial difference in patients with intermediate-2 and high IPSS risk. The majority of MF patients in real-world analysis started with a reduced dose of ruxolitinib, which is associated with less favourable outcomes

An Environmental and Climate History of the Roman Expansion in Italy

A first synthesis of available data for the period of Rome’s expansion in Italy (about 400–29 b.c.e.) shows the role of climate and environment in early Roman imperialism. Although global indices suggest a warmer phase with relatively few short-term climate events occuring around the same time as the expansion, local data emphasize the highly variable timing and expression of these trends. This variability casts doubt on ideas of a unitary, historically consequential “Roman Warm Period.” The historical importance of climate and environment to socioeconomic development merits emphasis, but should be understood in terms of evolving, contingent forms of resilience and risk-mitigating behavior by Italian communities during Roman expansion

Long-term effects of pulmonary endarterectomy on pulmonary hemodynamics, cardiac function, and exercise capacity in chronic thromboembolic pulmonary hypertension

Background: Long-term changes in exercise capacity and cardiopulmonary hemodynamics after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) have been poorly described. Methods: We analyzed the data from 2 prospective surgical CTEPH cohorts in Hammersmith Hospital, London, and Amsterdam UMC. A structured multimodal follow-up was adopted, consisting of right heart catheterization, cardiac magnetic resonance imaging, and cardiopulmonary exercise testing before and after PEA. Preoperative predictors of residual pulmonary hypertension (PH; mean pulmonary artery pressure &gt;20&nbsp;mm Hg and pulmonary vascular resistance ≥2&nbsp;WU) and long-term exercise intolerance (VO2max &lt;80%) at 18&nbsp;months were analyzed. Results: A total of 118 patients (61 from London and 57 from Amsterdam) were included in the analysis. Both cohorts displayed a significant improvement of pulmonary hemodynamics, right ventricular (RV) function, and exercise capacity 6&nbsp;months after PEA. Between 6 and 18&nbsp;months after PEA, there were no further improvements in hemodynamics and RV function, but the proportion of patients with impaired exercise capacity was high and slightly increased over time (52%-59% from 6 to 18&nbsp;months). Long-term exercise intolerance was common and associated with preoperative diffusion capacity for carbon monoxide (DLCO), preoperative mixed venous oxygen saturation, and postoperative PH and right ventricular ejection fraction (RVEF). Clinically significant RV deterioration (RVEF decline &gt;3%; 5 [9%] of 57 patients) and recurrent PH (5 [14%] of 36 patients) rarely occurred beyond 6&nbsp;months after PEA. Age and preoperative DLCO were predictors of residual PH post-PEA. Conclusions: Restoration in exercise tolerance, cardiopulmonary hemodynamics, and RV function occurs within 6&nbsp;months. No substantial changes occurred between 6 and 18&nbsp;months after PEA in the Amsterdam cohort. Nevertheless, long-term exercise intolerance is common and associated with postoperative RV function

The Botanical Record of Archaeobotany Italian Network - BRAIN: a cooperative network, database and website

The BRAIN (Botanical Records of Archaeobotany Italian Network) database and network was developed by the cooperation of archaeobotanists working on Italian archaeological sites. Examples of recent research including pollen or other plant remains in analytical and synthetic papers are reported as an exemplar reference list. This paper retraces the main steps of the creation of BRAIN, from the scientific need for the first research cooperation to the website which has a free online access since 2015

The Botanical Record of Archaeobotany Italian Network - BRAIN: a cooperative network, database and website

The BRAIN (Botanical Records of Archaeobotany Italian Network) database and network was developed by the cooperation of archaeobotanists working on Italian archaeological sites. Examples of recent research including pollen or other plant remains in analytical and synthetic papers are reported as an exemplar reference list. This paper retraces the main steps of the creation of BRAIN, from the scientific need for the first research cooperation to the website which has a free online access since 2015