Maîtrise de la fécondité et planification familiale au Sud

Une approche pluridisciplinaire de la pratique contraceptive dans une "Cité" de l'île Maurice, réalisée depuis 1991, révèle l'impact de trois types de facteurs influant sur la pratique régulière de la contraception : la difficulté pour une population défavorisée d'accéder aux services de planification familiale dans un environnement démuni d'une infrastructure socio-sanitaire élémentaire ; des facteurs socioculturels tels que la méconnaissance des notions élémentaires de physiologie, la religion, le rapport au corps (crainte d'effets secondaires), l'image de la femme chez les hommes et les rôles qui lui sont impartis, etc. ; l'inadéquation entre l'offre des prestations en matière de planification familiale et la demande telle qu'elle est exprimée par les habitants de la Cité. La diversité de ces facteurs (d'ordre économique, démographique, social et culturel), qui agissent de manière combinée, met en évidence la pertinence d'une approche micro-locale pluridisciplinaire. (Résumé d'auteur

Investigating the evolution of major Northern Hemisphere ice sheets during the last glacial-interglacial cycle

A 2.5-dimensional climate model of intermediate complexity, CLIMBER-2, fully coupled with the GREMLINS 3-D thermo-mechanical ice sheet model is used to simulate the evolution of major Northern Hemisphere ice sheets during the last glacial-interglacial cycle and to investigate the ice sheets responses to both insolation and atmospheric CO<sub>2</sub> concentration. This model reproduces the main phases of advance and retreat of Northern Hemisphere ice sheets during the last glacial cycle, although the amplitude of these variations is less pronounced than those based on sea level reconstructions. At the last glacial maximum, the simulated ice volume is 52.5×10<sup>15</sup> m<sup>3</sup> and the spatial distribution of both the American and Eurasian ice complexes is in reasonable agreement with observations, with the exception of the marine parts of these former ice sheets. <br> A set of sensitivity studies has also been performed to assess the sensitivity of the Northern Hemisphere ice sheets to both insolation and atmospheric CO<sub>2</sub>. Our results suggest that the decrease of summer insolation is the main factor responsible for the early build up of the North American ice sheet around 120 kyr BP, in agreement with benthic foraminifera δ<sup>18</sup>O signals. In contrast, low insolation and low atmospheric CO<sub>2</sub> concentration are both necessary to trigger a long-lasting glaciation over Eurasia

Between Treewidth and Clique-width

Many hard graph problems can be solved efficiently when restricted to graphs of bounded treewidth, and more generally to graphs of bounded clique-width. But there is a price to be paid for this generality, exemplified by the four problems MaxCut, Graph Coloring, Hamiltonian Cycle and Edge Dominating Set that are all FPT parameterized by treewidth but none of which can be FPT parameterized by clique-width unless FPT = W[1], as shown by Fomin et al [7, 8]. We therefore seek a structural graph parameter that shares some of the generality of clique-width without paying this price. Based on splits, branch decompositions and the work of Vatshelle [18] on Maximum Matching-width, we consider the graph parameter sm-width which lies between treewidth and clique-width. Some graph classes of unbounded treewidth, like distance-hereditary graphs, have bounded sm-width. We show that MaxCut, Graph Coloring, Hamiltonian Cycle and Edge Dominating Set are all FPT parameterized by sm-width

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo

Lipoproteins are an important class of surface associated proteins that have diverse roles and frequently are involved in the virulence of bacterial pathogens. As prolipoproteins are attached to the cell membrane by a single enzyme, prolipoprotein diacylglyceryl transferase (Lgt), deletion of the corresponding gene potentially allows the characterisation of the overall importance of lipoproteins for specific bacterial functions. We have used a Δlgt mutant strain of Streptococcus pneumoniae to investigate the effects of loss of lipoprotein attachment on cation acquisition, growth in media containing specific carbon sources, and virulence in different infection models. Immunoblots of triton X-114 extracts, flow cytometry and immuno-fluorescence microscopy confirmed the Δlgt mutant had markedly reduced lipoprotein expression on the cell surface. The Δlgt mutant had reduced growth in cation depleted medium, increased sensitivity to oxidative stress, reduced zinc uptake, and reduced intracellular levels of several cations. Doubling time of the Δlgt mutant was also increased slightly when grown in medium with glucose, raffinose and maltotriose as sole carbon sources. These multiple defects in cation and sugar ABC transporter function for the Δlgt mutant were associated with only slightly delayed growth in complete medium. However the Δlgt mutant had significantly reduced growth in blood or bronchoalveolar lavage fluid and a marked impairment in virulence in mouse models of nasopharyngeal colonisation, sepsis and pneumonia. These data suggest that for S. pneumoniae loss of surface localisation of lipoproteins has widespread effects on ABC transporter functions that collectively prevent the Δlgt mutant from establishing invasive infection

Last interglacial temperature evolution – a model inter-comparison

Abstract. There is a growing number of proxy-based reconstructions detailing the climatic changes during the Last Interglacial period. This period is of special interest because large parts of the globe were characterized by a warmer-than-present-day climate, making this period an interesting test bed for climate models in the light of projected global warming. However, mainly because synchronizing the different records is difficult, there is no consensus on a global picture of Last Interglacial temperature changes. Here we present the first model inter-comparison of transient simulations covering the Last Interglacial period. By comparing the different simulations we aim at investigating the robustness of the simulated surface air temperature evolution. The model inter-comparison shows a robust Northern Hemisphere July temperature evolution characterized by a maximum between 130–122 ka BP with temperatures 0.4 to 6.8 K above pre-industrial values. This temperature evolution is in line with the changes in June insolation and greenhouse-gas concentrations. For the evolution of July temperatures in the Southern Hemisphere, the picture emerging from the inter-comparison is less clear. However, it does show that including greenhouse-gas concentration changes is critical. The simulations that include this forcing show an early, 128 ka BP July temperature anomaly maximum of 0.5 to 2.6 K. The robustness of simulated January temperatures is large in the Southern Hemisphere and the mid-latitudes of the Northern Hemisphere. In these latitudes maximum January temperature anomalies of respectively −2.5 to 2 K and 0 to 2 K are simulated for the period after 118 ka BP. The inter-comparison is inconclusive on the evolution of January temperatures in the high-latitudes of the Northern Hemisphere. Further investigation of regional anomalous patterns and inter-model differences indicate that in specific regions, feedbacks within the climate system are important for the simulated temperature evolution. Firstly in the Arctic region, changes in the summer sea-ice cover control the evolution of Last Interglacial winter temperatures. Secondly, for the Atlantic region, the Southern Ocean and the North Pacific, possible changes in the characteristics of the Atlantic meridional overturning circulation are critical. The third important feedback, having an impact on the temperature evolution of the Northern Hemisphere, is shown to be the presence of remnant continental ice from the preceding glacial period. Another important feedback are changes in the monsoon regime which controls the evolution of temperatures over parts of Africa and India. Finally, the simulations reveal an important land-sea contrast, with temperature changes over the oceans lagging continental temperatures by up to several thousand years. The aforementioned feedback mechanisms tend to be highly model-dependent, indicating that specific proxy-data is needed to constrain future climate simulations and to further enhance our understanding of the evolution of the climate during the Last Interglacial period

A comparative analysis of contraceptive use in Africa: evidence from DHS

The aim of this article is to show a comparative analysis of contraceptive use in areas of traditionally high fertility that have gone through profound changes. Data have been taken from the latest Demographic and Health Surveys (DHS). Logistic regression models were adopted for four selected representative countries, namely Egypt, Mali, Namibia and Niger. There were two selection criteria: data should be recent, and selected countries should have high (Egypt 57.4%; Namibia 46.4%) or low (Mali 7.5%; Niger 10.0%) contraceptive use. The probability of using contraception when a woman has had one to four children is 2.4 times higher than when they have had no children. Contraception data are always gathered at a point of time, but crosssectional data are not sufficient to understand all the mechanisms hidden behind contraceptive use. Different contraceptive behaviours need good estimation tools to develop specific family planning programmes.Web of Scienc

Methylation levels of a novel genetic element, EgNB3 as a candidate biomarker associated with the embryogenic competency of oil palm

The association between DNA methylation status and embryogenic competency in oil palm tissue culture was examined through Representational Difference Analysis (RDA) approach, using methylation-sensitive restriction endonucleases. "Difference Products" (DPs) of RDA derived from palms of similar genetic backgrounds but exhibiting different embryogenesis rates during the regeneration process were isolated. The DPs were sequenced using a pyrosequencing platform. To our knowledge, this is the first study profiling partial HpaII methylation sites in oil palm young leaf tissues which are potentially associated with embryogenic amenability through a genomic subtractive approach. Quantitative real-time PCR analysis demonstrated that the methylation status of a novel fragment, EgNB3, was higher in highly embryogenic leaf explants compared to low embryogenesis rate materials. These differences are likely to be contributed by the 5′-mCCGG-3′ and/or 5′-mCmCGG-3′ methylation patterns. Our data suggest that the differentially methylated site in EgNB3 has potential as a molecular biomarker for the screening of oil palm leaf explants for their embryogenic potentials

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Relative importance of the mechanisms triggering the Eurasian ice sheet deglaciation in the GRISLI2.0 ice sheet model

The last deglaciation (21 to 8 ka) of the Eurasian ice sheet (EIS) is thought to have been responsible for a sea level rise of about 20 m. While many studies have examined the timing and rate of the EIS retreat during this period, many questions remain about the key processes that triggered the EIS deglaciation 21 kyr ago. Due to its large marine-based parts in the Barents–Kara (BKIS) and British Isles sectors, the BKIS is often considered to be a potential analogue of the current West Antarctic ice sheet (WAIS). Identifying the mechanisms that drove the EIS evolution might provide a better understanding of the processes at play in the West Antarctic destabilization. To investigate the relative impact of key drivers on the EIS destabilization, we used the three-dimensional ice sheet model GRISLI (GRenoble Ice Shelf and Land Ice) (version 2.0) forced by climatic fields from five Paleoclimate Modelling Intercomparison Project phases 3 and 4 (PMIP3, PMIP4) Last Glacial Maximum (LGM) simulations. In this study, we performed sensitivity experiments to test the response of the simulated Eurasian ice sheets to surface climate, oceanic temperatures (and thus basal melting under floating ice tongues), and sea level perturbations. Our results highlight that the EIS retreat simulated with the GRISLI model is primarily triggered by atmospheric warming. Increased atmospheric temperatures further amplify the sensitivity of the ice sheets to sub-shelf melting. These results contradict those of previous modelling studies mentioning the central role of basal melting on the deglaciation of the marine-based Barents–Kara ice sheet. However, we argue that the differences with previous works are mainly related to differences in the methodology followed to generate the initial LGM ice sheet. Due to the strong sensitivity of EIS to the atmospheric forcing highlighted with the GRISLI model and the limited extent of the confined ice shelves during the LGM, we conclude by questioning the analogy between EIS and the current WAIS. However, because of the expected rise in atmospheric temperatures, the risk of hydrofracturing is increasing and could ultimately put the WAIS in a configuration similar to the past Eurasian ice sheet.</p

Corrigendum to &quot;Influence of ablation-related processes in the build-up of simulated Northern Hemisphere ice sheets during the last glacial cycle&quot; published in The Cryosphere, 7, 681–698, 2013

No abstract available