Mass-spectrometric studies of new 6-nitroquipazines—serotonin transporter inhibitors

Six synthesized 6-nitroquipazine derivatives were examined by electron ionization (EI) and electrospray ionization (ESI) mass spectrometry in positive and negative ion mode. The compounds exhibit high affinity for the serotonin transporter (SERT) and belong to a new class of SERT inhibitors. The EI mass spectra registered in negative ion mode showed prominent molecular ions for all the compounds studied. All EI mass spectra and all ESI mass spectra showed similar fragmentation pathways of molecular ions, but the pathways differed between EI and ESI. The differences were explained with the aid of theoretical evaluation of the stability of the respective radical ions (EI MS) and protonated ions (ESI MS)

Genetic Divergence between Freshwater and Marine Morphs of Alewife (Alosa pseudoharengus): A ‘Next-Generation’ Sequencing Analysis

Alewife Alosa pseudoharengus, a small clupeid fish native to Atlantic Ocean, has recently (∼150 years ago) invaded the North American Great Lakes and despite challenges of freshwater environment its populations exploded and disrupted local food web structures. This range expansion has been accompanied by dramatic changes at all levels of organization. Growth rates, size at maturation, or fecundity are only a few of the most distinct morphological and life history traits that contrast the two alewife morphs. A question arises to what extent these rapidly evolving differences between marine and freshwater varieties result from regulatory (including phenotypic plasticity) or structural mutations. To gain insights into expression changes and sequence divergence between marine and freshwater alewives, we sequenced transcriptomes of individuals from Lake Michigan and Atlantic Ocean. Population specific single nucleotide polymorphisms were rare but interestingly occurred in sequences of genes that also tended to show large differences in expression. Our results show that the striking phenotypic divergence between anadromous and lake alewives can be attributed to massive regulatory modifications rather than coding changes

Structure et évolution du thymus de la Truite Arc-en-Ciel

International audienc

Microsporidiose des salmonidés : infestation des salmonidés de la Bresle

La Microsporidiose des Salmonidés précédemment observée dans le Sud-Ouest de la France atteint également les Salmonidés de la Bresie, fleuve côtier normand. Les truites de mer adultes (Salmo trutta fario) en période de reproduction et les jeunes saumons mâles (Salmo salar) sont plus particulièrement sensibles à cette parasitose. Les spores de microsporidies sont révélées sur des calques d'organes ou de tissus infestés

Microsporidiose des salmonidés : infestation des salmonidés de la Bresle

La Microsporidiose des Salmonidés précédemment observée dans le Sud-Ouest de la France atteint également les Salmonidés de la Bresie, fleuve côtier normand. Les truites de mer adultes (Salmo trutta fario) en période de reproduction et les jeunes saumons mâles (Salmo salar) sont plus particulièrement sensibles à cette parasitose. Les spores de microsporidies sont révélées sur des calques d'organes ou de tissus infestés

Structure et évolution du thymus de la Truite Arc-en-Ciel

International audienc