44 research outputs found
Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects
Italy
Navigating the intricate domain of business ethics in Italy unveils a
distinctive journey, diverging from the philosophical roots that dominate
other global contexts. Unlike in the USA, where philosophers primarily
shaped the discourse, Italy’s narrative is particularly intricately woven
with the contributions of scholars in “Economia aziendale” — the realm
of management, accounting, and organization. This introductory exploration
traces the evolution of Italian business ethics, emphasizing the enduring
influence of managerial and accounting disciplines. Since 2011,
academic discussions in Italy have surged, spotlighting corporate responsibility
and sustainability. This survey-based study delves into the nuanced
landscape, dissecting the focus on teaching, research, and training
Individual housing induces altered immuno-endocrine responses to psychological stress in male mice
Social isolation and lack of social support have deleterious effects on health, thus being regarded as one of the most relevant causes of diseases in human and other mammalian species. However, only few are the studies aimed at evaluating the psychoneuroimmunological functions of individually housed subjects. The present study was designed to understand how the behavior and the physiology of male house mice might be affected by individual housing. We first analyzed whether individual housing of different duration (1-42 days) would result in immuno-endocrine dysfunction (experiment 1). Then we investigated whether housing conditions would affect the reaction to an acute mild psychological stress (experiments 2 and 3). There were three main findings: first, individually housing mice for increasing time periods did not induce any major immuno-endocrine effects compared to a stable sibling group housing. Therefore, prolonged isolation does not seem to dramatically impair mice immuno-endocrine functions. Second, when exposed to a mild acute stress, i.e. forced exposure to a novel environment, isolated mice showed higher basal corticosterone and lower type 1 (IL-2) and type 2 (IL-4) cytokines as well as splenocytes proliferation compared to group housed male mice. Finally, when faced with a free choice between a novel environment and their home cage, individually housed mice showed reduced neophobic responses resulting in increased exploration of the novel environment, thus suggesting a low anxiety profile. Altogether, our findings suggest that individual housing in itself does not change immunocompetence and corticosterone level, but does affect reactivity to a stressor. In fact, individually housed mice showed high behavioral arousal, as well as altered immuno-endocrine parameters, when challenged with mild psychological novelty-stress
