Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition

Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum. Here we study protein aggregation kinetics by mean-field reactions and three dimensional Monte carlo simulations of diffusion-limited aggregation of linear polymers in a confined space, representing the endoplasmic reticulum. By tuning the rates of protein production and degradation, we show that the system undergoes a non-equilibrium phase transition from a physiological phase with little or no polymer accumulation to a pathological phase characterized by persistent polymerization. A combination of external factors accumulating during the lifetime of a patient can thus slightly modify the phase transition control parameters, tipping the balance from a long symptomless lag phase to an accelerated pathological development. The model can be successfully used to interpret experimental data on amyloid-\b{eta} clearance from the central nervous system

EAPC task force on education for psychologists in palliative care

It is argued that psychological aspects of care and psychosocial problems are essential components of palliative care. However, the provision of appropriate services remains somewhat arbitrary. Unlike medical and nursing care, which are clearly delivered by doctors and nurses respectively, psychological and psychosocial support in palliative care are not assigned exclusively to psychologists. It is generally expected that all professionals working in palliative care should have some knowledge of the psychological dynamics in terminal illness, as well as skills in communication and psychological risk assessment. On the one hand, palliative care education programmes for nurses and doctors comprise a considerable amount of psychological and psychosocial content. On the other hand, only a few palliative care associations provide explicit information on the role and tasks of psychologists in palliative care. Psychologists’ associations do not deal much with this issue either. If they refer to it at all, it is in the context of the care of the aged, end-of-life care or how to deal with grief

Chandra imaging of the ∼\simkpc extended outflow in 1H 0419-577

The Seyfert 1 galaxy 1H 0419-577 hosts a $\sim$kpc extended outflow that is evident in the [\ion{O}{iii}] image and that is also detected as a warm absorber in the UV/X-ray spectrum. Here, we analyze a $\sim$30 ks Chandra-ACIS X-ray image, with the aim of resolving the diffuse extranuclear X-ray emission and of investigating its relationship with the galactic outflow. Thanks to its sub-arcsecond spatial resolution, Chandra resolves the circumnuclear X-ray emission, which extends up to a projected distance of at least $\sim$16 kpc from the center. The morphology of the diffuse X-ray emission is spherically symmetrical. We could not recover a morphological resemblance between the soft X-ray emission and the ionization bicone that is traced by the [\ion{O}{iii}] outflow. we argue that the photoionized gas nebula must be distributed mostly along the polar directions, outside our line of sight. In this geometry, the X-ray/UV warm absorber must trace a different gas component, physically disconnected from the emitting gas, and located closer to the equatorial plane.Comment: accepted for publications A&

Statistical equilibrium in simple exchange games I

Simple stochastic exchange games are based on random allocation of finite resources. These games are Markov chains that can be studied either analytically or by Monte Carlo simulations. In particular, the equilibrium distribution can be derived either by direct diagonalization of the transition matrix, or using the detailed balance equation, or by Monte Carlo estimates. In this paper, these methods are introduced and applied to the Bennati-Dragulescu-Yakovenko (BDY) game. The exact analysis shows that the statistical-mechanical analogies used in the previous literature have to be revised.Comment: 11 pages, 3 figures, submitted to EPJ

Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity

Background and aim: Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk. SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. We aimed to assess the relationship of EF thickness (EFT) with circulating SIRT1 in patients with obesity. Methods and results: Sixty-two patients affected by obesity and 23 lean controls were studied. Plasma SIRT1 concentration was determined by enzyme-linked immunosorbent assay (ELISA). EFT was measured by echocardiography. Body mass index (BMI), waist circumference, heart rate (HR), blood pressure, and laboratory findings (fasting glucose, insulin, HbA1c, cholesterol, and triglycerides) were assessed. SIRT1 was significantly lower (P = 0.002) and EFT was higher (P < 0.0001) in patients with obesity compared with lean controls. SIRT1 showed a negative correlation with EFT and HR in the obesity group (rho = -0.350, P = 0.005; rho = -0.303, P = 0.008, respectively). After adjustment for obesity-correlated variables, multiple linear regression analysis showed that EFT remained the best correlate of SIRT1 (beta = -0.352, P = 0.016). Conclusions: Circulating SIRT1 correlates with the visceral fat content of the heart. Serum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved

The Soil Erosion Risk Map of the Sicilian Region (1:250,000 Scale)

Assessing the risk areas of soil erosion by water at the regional level is relevant for current and future land planning of environmental actions to combat land degradation. The gravity of the risk is not only depending on the rate of soil erosion by water, but also on other factors, primarily soil depth and rock weatherability. The map of the soil erosion risk in the Sicilian region, expressed in terms of years to a complete loss of the fertile soil cover, is here presented as a methodological model. The degree of risk was not only estimated in function of the rate of soil erosion by water, but also of the depth of the fertile part of the profile, and of the weatherability degree of the underlying bedrock

ISM composition through X-ray spectroscopy of LMXBs

The diffuse interstellar medium (ISM) is an integral part of the evolution of the entire Galaxy. Metals are produced by stars and their abundances are the direct testimony of the history of stellar evolution. However, the interstellar dust composition is not well known and the total abundances are yet to be accurately determined. We probe ISM dust composition, total abundances, and abundance gradients through the study of interstellar absorption features in the high-resolution X-ray spectra of Galactic low-mass X-ray binaries (LMXBs). We use high-quality grating spectra of nine LMXBs taken with XMM-Newton. We measure the column densities of O, Ne, Mg, and Fe with an empirical model and estimate the Galactic abundance gradients. The column densities of the neutral gas species are in agreement with those found in the literature. Solids are a significant reservoir of metals like oxygen and iron. Respectively, 15-25 % and 65-90 % of the total amount of O I and Fe I is found in dust. The dust amount and mixture seem to be consistent along all the lines-of-sight (LOS). Our estimates of abundance gradients and predictions of local interstellar abundances are in agreement with those measured at longer wavelengths. Our work shows that X-ray spectroscopy is a very powerful method to probe the ISM. For instance, on a large scale the ISM appears to be chemically homogeneous showing similar gas ionization ratios and dust mixtures. The agreement between the abundances of the ISM and the stellar objects suggests that the local Galaxy is also chemically homogeneous.Comment: 13 pages, 10 figures, 5 tables, accepted to A&

Protocol for soil functionality assessment in vineyards

Protocols used by Resolve partners during the project, to assess soil functionality on degraded aeras and evaluate soil restoration after applying recovering practices

Behind the dust curtain: the spectacular case of GRB 160623A

We report on the X-ray dust-scattering features observed around the afterglow of the gamma ray burst GRB 160623A. With an XMM-Newton observation carried out ~2 days after the burst, we found evidence of at least six rings, with angular size expanding between ~2 and 9 arcmin, as expected for X-ray scattering of the prompt GRB emission by dust clouds in our Galaxy. From the expansion rate of the rings, we measured the distances of the dust layers with extraordinary precision: 528.1 +\- 1.2 pc, 679.2 +\- 1.9 pc, 789.0 +\- 2.8 pc, 952 +\- 5 pc, 1539 +\- 20 pc and 5079 +\- 64 pc. A spectral analysis of the ring spectra, based on an appropriate dust-scattering model (BARE-GR-B from Zubko et al. 2004}) and the estimated burst fluence, allowed us to derive the column density of the individual dust layers, which are in the range 7x10^20-1.5x10^22 cm^-2. The farthest dust-layer (i.e. the one responsible for the smallest ring) is also the one with the lowest column density and it is possibly very extended, indicating a diffuse dust region. The properties derived for the six dust-layers (distance, thickness, and optical depth) are generally in good agreement with independent information on the reddening along this line of sight and on the distribution of molecular and atomic gas.Comment: 9 pages, 10 figures, 1 table; accepted for publication in MNRA