11,323 research outputs found
Short communication: First report of thresher sharks (Alopiidae) in the Gulf of Antalya
Generally, Alopiidae family members are active, strong-swimming, pelagic, coastal and deep-water sharks. They are characterized by a very long upper caudal lobe. They have two dorsal fins; the second dorsal and anal fins are very small. They can be found in all warm oceans and mainly feed on small to moderately large schooling fishes and squids. Up to now, only three species have been described in family Alopiidae with two of them Alopias vulpinus (Bonnaterre, 1788) and Alopias superciliosus (Lowe, 1839) reported from the Mediterranean Sea. The third species (A. pelagicus) is reported from the Pacific Ocean. ... This study aimed to improve the lack of data on these species in the Mediterranean Sea
A novel non-Fermi-liquid state in the iron-pnictide FeCrAs
We report transport and thermodynamic properties of stoichiometric single
crystals of the hexagonal iron-pnictide FeCrAs. The in-plane resistivity shows
an unusual "non-metallic" dependence on temperature T, rising continuously with
decreasing T from ~ 800 K to below 100 mK. The c-axis resistivity is similar,
except for a sharp drop upon entry into an antiferromagnetic state at T_N 125
K. Below 10 K the resistivity follows a non-Fermi-liquid power law, rho(T) =
rho_0 - AT^x with x<1, while the specific heat shows Fermi liquid behaviour
with a large Sommerfeld coefficient, gamma ~ 30 mJ/mol K^2. The high
temperature properties are reminiscent of those of the parent compounds of the
new layered iron-pnictide superconductors, however the T -> 0 properties
suggest a new class of non-Fermi liquid.Comment: 6 pages, 4 figure
Bod1, a novel kinetochore protein required for chromosome biorientation
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule–kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects. Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles
Dynamical Imaging with Interferometry
By linking widely separated radio dishes, the technique of very long baseline
interferometry (VLBI) can greatly enhance angular resolution in radio
astronomy. However, at any given moment, a VLBI array only sparsely samples the
information necessary to form an image. Conventional imaging techniques
partially overcome this limitation by making the assumption that the observed
cosmic source structure does not evolve over the duration of an observation,
which enables VLBI networks to accumulate information as the Earth rotates and
changes the projected array geometry. Although this assumption is appropriate
for nearly all VLBI, it is almost certainly violated for submillimeter
observations of the Galactic Center supermassive black hole, Sagittarius A*
(Sgr A*), which has a gravitational timescale of only ~20 seconds and exhibits
intra-hour variability. To address this challenge, we develop several
techniques to reconstruct dynamical images ("movies") from interferometric
data. Our techniques are applicable to both single-epoch and multi-epoch
variability studies, and they are suitable for exploring many different
physical processes including flaring regions, stable images with small
time-dependent perturbations, steady accretion dynamics, or kinematics of
relativistic jets. Moreover, dynamical imaging can be used to estimate
time-averaged images from time-variable data, eliminating many spurious image
artifacts that arise when using standard imaging methods. We demonstrate the
effectiveness of our techniques using synthetic observations of simulated black
hole systems and 7mm Very Long Baseline Array observations of M87, and we show
that dynamical imaging is feasible for Event Horizon Telescope observations of
Sgr A*.Comment: 16 Pages, 12 Figures, Accepted for publication in Ap
A common variant associated with dyslexia reduces expression of the KIAA0319 gene
This work was supported by the Wellcome Trust (MYD, SP, TSS, JCK, RWM, PC, SB, and APM), the Intramural Research Programs of the National Human Genome Research Institute (MYD and EDG) and National Cancer Institute (MPO), and the NIH/Ox-Cam Graduate Partnership Program (MYD).Numerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility. The causative variant(s) remains unknown but may modulate gene expression, given that (1) a dyslexia-associated haplotype has been implicated in the reduced expression of KIAA0319, and (2) the strongest association has been found for the region spanning exon 1 of KIAA0319. Here, we test the hypothesis that variant(s) responsible for reduced KIAA0319 expression resides on the risk haplotype close to the gene's transcription start site. We identified seven single-nucleotide polymorphisms on the risk haplotype immediately upstream of KIAA0319 and determined that three of these are strongly associated with multiple reading-related traits. Using luciferase-expressing constructs containing the KIAA0319 upstream region, we characterized the minimal promoter and additional putative transcriptional regulator regions. This revealed that the minor allele of rs9461045, which shows the strongest association with dyslexia in our sample (max p-value = 0.0001), confers reduced luciferase expression in both neuronal and non-neuronal cell lines. Additionally, we found that the presence of this rs9461045 dyslexia-associated allele creates a nuclear protein-binding site, likely for the transcriptional silencer OCT-1. Knocking down OCT-1 expression in the neuronal cell line SHSY5Y using an siRNA restores KIAA0319 expression from the risk haplotype to nearly that seen from the non-risk haplotype. Our study thus pinpoints a common variant as altering the function of a dyslexia candidate gene and provides an illustrative example of the strategic approach needed to dissect the molecular basis of complex genetic traits.PostprintPeer reviewe
Measuring Stellar Radial Velocities with a Dispersed Fixed-Delay Interferometer
We demonstrate the ability to measure precise stellar barycentric radial
velocities with the dispersed fixed-delay interferometer technique using the
Exoplanet Tracker (ET), an instrument primarily designed for precision
differential Doppler velocity measurements using this technique. Our
barycentric radial velocities, derived from observations taken at the KPNO 2.1
meter telescope, differ from those of Nidever et al. by 0.047 km/s (rms) when
simultaneous iodine calibration is used, and by 0.120 km/s (rms) without
simultaneous iodine calibration. Our results effectively show that a Michelson
interferometer coupled to a spectrograph allows precise measurements of
barycentric radial velocities even at a modest spectral resolution of R ~ 5100.
A multi-object version of the ET instrument capable of observing ~500 stars per
night is being used at the Sloan 2.5 m telescope at Apache Point Observatory
for the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS),
a wide-field radial velocity survey for extrasolar planets around TYCHO-2 stars
in the magnitude range 7.6<V<12. In addition to precise differential
velocities, this survey will also yield precise barycentric radial velocities
for many thousands of stars using the data analysis techniques reported here.
Such a large kinematic survey at high velocity precision will be useful in
identifying the signature of accretion events in the Milky Way and
understanding local stellar kinematics in addition to discovering exoplanets,
brown dwarfs and spectroscopic binaries.Comment: 9 pages, 4 figures. Accepted for publication in Ap
Metamagnetic Quantum Criticality
A renormalization group treatment of metamagnetic quantum criticality in
metals is presented. In clean systems the universality class is found to be of
the overdamped, conserving (dynamical exponent z=3) Ising type. Detailed
results are obtained for the field and temperature dependence of physical
quantities including the differential susceptibility, resistivity and specific
heat near the transition. An application of the theory is made to Sr3Ru2O7,
which appears to exhibit a metamagnetic critical end-point at a very low
temperature and a field of order 5-7T.Comment: 4 pages latex (Revtex 4) and 3 eps figure
Interplay of disorder and spin fluctuations in the resistivity near a quantum critical point
The resistivity in metals near an antiferromagnetic quantum critical point
(QCP) is strongly affected by small amounts of disorder. In a quasi-classical
treatment, we show that an interplay of strongly anisotropic scattering due to
spin fluctuations and isotropic impurity scattering leads to a large regime
where the resistivity varies as T^alpha, with an anomalous exponent, alpha, 1
<= alpha <= 1.5, depending on the amount of disorder. I argue that this
mechanism explains in some detail the anomalous temperature dependence of the
resistivity observed in CePd_2Si_2, CeNi_2Ge_2 and CeIn_3 near the QCP.Comment: 4 pages, 4 eps figures, published version, only small change
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