Analisis Kesediaan Membayar Wtp (Willingness To Pay) dalam Upaya Pengelolaan Obyek Wisata Taman Alun Kapuas Pontianak, Kalimantan Barat

Berbagai fungsi yang terkait dengan sumber daya alam (fungsi ekologis, sosial, ekonomi, dan arsitektural) dannilai estetika yang dimilikinya (obyek dan lingkungan) dapat meningkatkan kualitas lingkungan dan untukkelangsungan kehidupan perkotaan juga dapat menjadi nilai kebanggaan dan identitas kota. Sebagai obyekwisata alam, Taman Alunalun Kapuas belum tertata dengan baik, pelaksanaan upaya pengelolaan objek wisataTaman Alun Kapuas membutuhkan biaya yang tidak sedikit. Untuk itu diharapkan bagi pengunjung untukmembayar dalam pengelolaan Taman Alun Kapuas. Penelitian ini menggunakan analisis regresi logistik dalammenganalisis faktor-faktor kesediaan pengunjung untuk membayar. Sedangkan metode CVM (ContingenValuation Method) digunakan untuk mengestimasi biaya yang akan dikeluarkan oleh pengunjung, dan metoderegresi berganda digunakan untuk menganalisis faktor-faktor apa yang mempengaruhi besar kesediaanmembayar pengunjung. Program yang dapat membantu dalam penelitian ini yaitu Microsoft Excel 2007 danMinitab For Windows Realise 16. Hasil penelitian menunjukkan bahwa sebanyak 84% responden bersediamembayar dalam upaya pengelolaan lingkungan obyek wisata Taman Alun Kapuas. Faktor-faktor yangmempengaruhi kesediaan membayar responden pengunjung dalam upaya pengelolaan lingkungan obyekwisata Taman Alun Kapuas antara lain pendapatan (PNDPTN3) dan pengetahuan (PNGTHUAN). Nilai rata-rataWTP responden pengunjung adalah sebesar Rp 3360,00/orang. Faktor yang mempengaruhi nilai WTPresponden yaitu usia (U)

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or those with lesion activity on imaging. We sought to assess whether natalizumab slows disease progression in secondary progressive multiple sclerosis, independent of relapses. Methods: ASCEND was a phase 3, randomised, double-blind, placebo-controlled trial (part 1) with an optional 2 year open-label extension (part 2). Enrolled patients aged 18–58 years were natalizumab-naive and had secondary progressive multiple sclerosis for 2 years or more, disability progression unrelated to relapses in the previous year, and Expanded Disability Status Scale (EDSS) scores of 3·0–6·5. In part 1, patients from 163 sites in 17 countries were randomly assigned (1:1) to receive 300 mg intravenous natalizumab or placebo every 4 weeks for 2 years. Patients were stratified by site and by EDSS score (3·0–5·5 vs 6·0–6·5). Patients completing part 1 could enrol in part 2, in which all patients received natalizumab every 4 weeks until the end of the study. Throughout both parts, patients and staff were masked to the treatment received in part 1. The primary outcome in part 1 was the proportion of patients with sustained disability progression, assessed by one or more of three measures: the EDSS, Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9HPT). The primary outcome in part 2 was the incidence of adverse events and serious adverse events. Efficacy and safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01416181. Findings: Between Sept 13, 2011, and July 16, 2015, 889 patients were randomly assigned (n=440 to the natalizumab group, n=449 to the placebo group). In part 1, 195 (44%) of 439 natalizumab-treated patients and 214 (48%) of 448 placebo-treated patients had confirmed disability progression (odds ratio [OR] 0·86; 95% CI 0·66–1·13; p=0·287). No treatment effect was observed on the EDSS (OR 1·06, 95% CI 0·74–1·53; nominal p=0·753) or the T25FW (0·98, 0·74–1·30; nominal p=0·914) components of the primary outcome. However, natalizumab treatment reduced 9HPT progression (OR 0·56, 95% CI 0·40–0·80; nominal p=0·001). In part 1, 100 (22%) placebo-treated and 90 (20%) natalizumab-treated patients had serious adverse events. In part 2, 291 natalizumab-continuing patients and 274 natalizumab-naive patients received natalizumab (median follow-up 160 weeks [range 108–221]). Serious adverse events occurred in 39 (13%) patients continuing natalizumab and in 24 (9%) patients initiating natalizumab. Two deaths occurred in part 1, neither of which was considered related to study treatment. No progressive multifocal leukoencephalopathy occurred. Interpretation: Natalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component. Longer-term trials are needed to assess whether treatment of secondary progressive multiple sclerosis might produce benefits on additional disability components. Funding: Biogen

HIV infection and sexual risk among men who have sex with men and women (MSMW): A systematic review and meta-analysis

Objectives: To estimate the number of men who have sex with men and women who are HIV-positive in the United States, and to compare HIV prevalence rates between men who have sex with men and women, men who have sex with men only, and men who have sex with women exclusively. Methods: Following PRISMA guidelines, we conducted a systematic review and meta-analysis of reports referencing HIV prevalence and men who have sex with men and women. We searched PubMed and Ovid PsycINFO for peer-reviewed, U.S.-based articles reporting on HIV prevalence among men who have sex with men and women. We conducted event rate, effect size, moderation and sensitivity analyses. Results: We estimate that 1.0% of U.S. males are bisexually-behaving, and that 121,800 bisexually-behaving men are HIV-positive. Men who have sex with men and women are less than half as likely to be HIV-positive as men who have sex with men only (16.9% vs. 33.3%; OR = 0.41, 95% CI: 0.31, 0.54), but more than five times as likely to be HIV-positive as men who have sex with women exclusively (18.3% vs. 3.5%; OR = 5.71, 95% CI: 3.47, 9.39). They are less likely to engage in unprotected receptive anal intercourse than men who have sex with men only (15.9% vs. 35.0%; OR = 0.36, 95% CI: 0.28, 0.46). Men who have sex with men and women in samples with high racial/ethnic minority proportions had significantly higher HIV prevalence than their counterparts in low racial/ethnic minority samples. Conclusions: This represents the first meta-analysis of HIV prevalence in the U.S. between men who have sex with men and women and men who have sex with men only. Data collection, research, and HIV prevention and care delivery specifically tailored to men who have sex with men and women are necessary to better quantify and ameliorate this population's HIV burden. © 2014 Friedman et al

An invitation to use craigslist ads to recruit respondents from stigmatized groups for qualitative interviews

Craigslist.org is a website devoted to classified advertisements as well as discussion forums with locations in more than 700 sites in 70 countries. At an estimated 30 billion page views per month and more than 50 million new classified ads posted monthly, craigslist ads have the ability to reach a wide audience. Although wildly popular, no studies to date have investigated the use of craigslist ads for qualitative research study recruitment. In this research note, I offer my own experiences from 2011 to 2012 using craigslist ads (N = 77) to recruit obese respondents (N = 38) for qualitative interviews in one major metro area in the southern United States. I also discuss some advantages and limitations of using craigslist as a recruitment tool. Overall, I invite social science researchers to consider craigslist as an innovative tool to recruit respondents for qualitative research.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

THE ANALYSIS OF YOUNG-OF-THE-YEAR CARP FEEDING WHEN FERTILIZING THE PONDS WITH DIFFERENT ORGANIC FERTILIZERS

В статті представлено результати досліджень щодо живлення цьоголіток коропа в ставах із застосуванням різних органічних удобрювачів.Встановлено, що внесення у дослідні стави пивної дробини та перегною ВРХ сприяло підвищенню рівня розвитку природної кормової бази. Отримані дані щодо живлення цьоголіток коропа в ставах з різними варіантами удобрення свідчать, що риба в усіх варіантах досліду була забезпечена природним кормом. Його відносний вміст в раціоні цьоголіток коропа дослідних груп складав 42,2±4,2–46,7±4,1 % і був у 1,2–1,3 рази вищий, ніж у контрольних (35,3±4,4 %). Індекс наповнення кишкового тракту риб при внесенні пивної дробини впродовж вегетаційного сезону поступово збільшувався; при внесенні перегною – збільшувався на початку періоду вирощування, із наступним зниженням його з початком годівлі штучними кормами; у контролі даний показник мав чітку тенденцію до зниження. Середні за вегетаційний сезон індекси наповнення кишкового тракту цьоголіток коропа в досліді були на рівні 256,5±22,4 – 348,1±23,5%, у контролі – 239,8±31,1 %.В статье представлены результаты исследования питания сеголеток карпа в прудах с применением различных органических  удобрителей. Установлено, что внесение в опытные пруды пивной дробины и перегноя КРС способствовало повышению уровня развития естественной кормовой базы. Полученные данные относительно питания сеголеток карпа в прудах с различными вариантами удобрения свидетельствуют, что рыба во всех вариантах опыта была обеспечена естественным кормом. Его относительное содержание в рационе сеголеток карпа опытных групп составляло 42,2±4,2–46,7±4,1 % и было в 1,2–1,3 раза выше, чем в контрольных (35,3±4,4 %). Индекс наполнения кишечного тракта рыб при внесении пивной дробины в течение вегетационного сезона постепенно увеличивался; при внесении перегноя – увеличивался в начале периода выращивания, с последующим снижением его с началом кормления искусственными кормами; в контроле данный показатель имел четкую тенденцию к снижению. Средние за вегетационный сезон индексы наполнения кишечного тракта сеголеток карпа в опыте были на уровне 256,5±22,4 – 348,1±23,5%, в контроле – 239,8±31,1%.The paper contains the results of the studies on young-of-the-year carp feeding in ponds with the application of different organic fertilizers.It was found that the application of brewer’s grains and cattle manure into ponds contributed to an increase in the level of the development of feeding organisms. The obtained data on young-of-the-year carp feeding in ponds with different fertilization variants indicate that fish in all experimental variants was supplied with natural feeds. Its relative content in young-of-the-year carp diet in experimental groups was 42.2±4.2-46.7±4.1% that was 1.2–1.3 times higher than in the control (35.3±4.4 %). Gut fullness index of the experimental fish when brewer’s grains were used gradually increased during the culture season; when manure was used – it increased in the beginning of the growing period and then reduced with the start of feeding fish with artificial feeds; in the control, this index had a clear tendency for decreasing. Mean gut fullness indices of young-of-the-year carp during the culture season were 256.5±22.4 – 348.1±23.5% in the experiment and 239.8±31.1% in the control

Fetal arterial and venous Doppler in growth restricted fetuses for the prediction of perinatal complications

Fetal arterial and venous Doppler is a useful tool for the monitoring of growth restricted fetuses. Our aim in this study was to compare outcomes when fetuses were grouped according to the combinations of the Doppler results and also according to each vessel Doppler. Deliveries during the period 2002-2008 were reviewed retrospectively and cases with a birth weight less than the 10th percentile were selected for the study. Cases with congenital malformations or chromosomal abnormalities were excluded. Cases were then grouped according to umbilical artery (UA), middle cerebral artery (MCA) and ductus venosus (DV) Doppler results. Two hundred fifty-five cases were selected for the study. The perinatal mortality rate was 9.8% (11 prenatal and 14 neonatal). In the presence of absent or reverse flow in UA, fetal death and neonatal complication rates were higher. In the fetuses having reverse or absent "a" wave, there were findings of metabolic deterioration. Absent-reverse UA end-diastolic flow increased the odds ratios of perinatal and fetal death, bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), respiratory distress syndrome (RDS), and need for neonatal intensive care unit (NICU) (2.81, 5.94, 10.82, 5.79, 5.19, and 11.60, respectively). Absent/reverse "a" wave in DV increased the odds ratio of perinatal death, fetal death, neonatal death, RDS, and abnormal pH (19.89, 18.06, 12.50, 8.29, and 9.67, respectively). For prediction of fetal metabolic status, DV Doppler is a reliable tool. However, when perinatal complications are considered, this finding for intervention to delivery is a late point. Therefore, when reverse end-diastolic flow in the UA is observed, decision-to-delivery should be taken in order to avoid metabolic deterioration and increased postpartum death

Differential Effects of Migration and Deportation on HIV Infection among Male and Female Injection Drug Users in Tijuana, Mexico

HIV prevalence is rising, especially among high risk females in Tijuana, Baja California, a Mexico-US border city situated on major migration and drug trafficking routes. We compared factors associated with HIV infection among male and female injection drug users (IDUs) in Tijuana in an effort to inform HIV prevention and treatment programs. IDUs aged ≥18 years were recruited using respondent-driven sampling and underwent testing for HIV, syphilis and structured interviews. Logistic regression identified correlates of HIV infection, stratified by gender. Among 1056 IDUs, most were Mexican-born but 67% were born outside Tijuana. Reasons for moving to Tijuana included deportation from the US (56% for males, 29% for females), and looking for work/better life (34% for females, 15% for males). HIV prevalence was higher in females versus males (10.2% vs. 3.5%, p = 0.001). Among females (N = 158), factors independently associated with higher HIV prevalence included younger age, lifetime syphilis infection and living in Tijuana for longer durations. Among males (N = 898), factors independently associated with higher HIV prevalence were syphilis titers consistent with active infection, being arrested for having ‘track-marks’, having larger numbers of recent injection partners and living in Tijuana for shorter durations. An interaction between gender and number of years lived in Tijuana regressed on HIV infection was significant (p = 0.03). Upon further analysis, deportation from the U.S. explained the association between shorter duration lived in Tijuana and HIV infection among males; odds of HIV infection were four-fold higher among male injectors deported from the US, compared to other males, adjusting for all other significant correlates (p = 0.002). Geographic mobility has a profound influence on Tijuana's evolving HIV epidemic, and its impact is significantly modified by gender. Future studies are needed to elucidate the context of mobility and HIV acquisition in this region, and whether US immigration policies adversely affect HIV risk