Spatial Effects of NAO on Temperature and Precipitation Anomalies in Italy

The NAO teleconnective pattern has a great influence on the European climate; however, the exact quantification of NAO pattern in the different areas is sometimes lacking, and at other times, highlights even large differences between the various studies. This motivation led to the identification of the aim of this research in the study of the relationship between the NAO index and temperature and precipitation anomalies over the period 1991-2020, through the analysis of 87 rain gauges and 86 thermometric stations distributed as homogeneously as possible over the Italian territory. The results were sometimes at odds with the scientific literature on the subject, as significance was also found outside the winter season, e.g., in the spring for temperatures and in the autumn for precipitation, and in some cases, correlations were found, especially in August, even in southern Italy, which is usually considered a poorly correlated area. In addition, the linear relationship between the NAO index and temperature and precipitation anomalies was verified, with many weather stations obtaining significant coefficients of determinations as high as 0.5-0.6 in December, with 29 degrees of freedom, and a p-value set at 95%. Finally, for both climatic parameters, the presence of clusters and outliers at seasonal and monthly levels was assessed, obtaining a spatial distribution using the local Moran index, and summarising them in maps. This analysis highlighted important clusters in Northern and Central Italy, while clusters in the summer months occur in the South. These results provide information that may further elucidate local atmospheric dynamics in relation to NAO phases, as well as encourage future studies that may link other teleconnective indices aimed at better explaining the variance of climate parameters

ANMCO POSITION PAPER: Timing of coronary angiography in non-ST-segment elevation acute coronary syndromes

The European Society of Cardiology guidelines on non-ST-elevation acute coronary syndromes suggest different temporal strategies for the angiographic study depending on the risk profile. The scientific evidence underlying the guideline recommendations and the critical issues currently existing in Italy, that often do not allow either an extended strategy of revascularization within 24 h or the application of the principle of the same day transfer from a spoke to a hub centre, are analysed. The position paper focuses, in particular, on the subgroup of patients with a defined diagnosis of non-ST-elevation myocardial infarction by proposing a timing of coronary angiography/revascularization that takes into account the available scientific evidence and the organizational possibilities of a considerable part of national cardiology services

Incidence of post myocardial infarction left ventricular thrombus formation in the era of primary percutaneous intervention and glycoprotein IIb/IIIa inhibitors. A prospective observational study

BACKGROUND: Before the widespread use of primary percutaneous coronary intervention (PCI) and glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa) left ventricular (LV) thrombus formation had been reported to complicate up to 20% of acute myocardial infarctions (AMI). The incidence of LV thrombus formation with these treatment modalities is not well known. METHODS: 92 consecutive patients with ST-elevation AMI treated with PCI and GP IIb/IIIa inhibitors underwent 2-D echocardiograms, with and without echo contrast agent, within 24–72 hours. RESULTS: Only 4/92 (4.3%) had an LV thrombus, representing a significantly lower incidence than that reported in the pre-PCI era. Use of contrast agents did not improve detection of LV thrombi in our study. CONCLUSION: The incidence of LV thrombus formation after acute MI, in the current era of rapid reperfusion, is lower than what has been historically reported

Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas

<p>Abstract</p> <p>Background</p> <p>Meningiomas may occur either as familial tumors in two distinct disorders, familial multiple meningioma and neurofibromatosis 2 (NF2), or sporadically, as either single or multiple tumors in individuals with no family history. Meningiomas in NF2 and approximately 60% of sporadic meningiomas involve inactivation of the <it>NF2 </it>locus, encoding the tumor suppressor merlin on chromosome 22q. This study was undertaken to establish whether genomic profiling could distinguish familial multiple meningiomas from sporadic solitary and sporadic multiple meningiomas.</p> <p>Methods</p> <p>We compared 73 meningiomas presenting as sporadic solitary (64), sporadic multiple (5) and familial multiple (4) tumors using genomic profiling by array comparative genomic hybridization (array CGH).</p> <p>Results</p> <p>Sporadic solitary meningiomas revealed genomic rearrangements consistent with at least two mechanisms of tumor initiation, as unsupervised cluster analysis readily distinguished tumors with chromosome 22 deletion (associated with loss of the <it>NF2 </it>tumor suppressor) from those without chromosome 22 deletion. Whereas sporadic meningiomas without chromosome 22 loss exhibited fewer chromosomal imbalance events overall, tumors with chromosome 22 deletion further clustered into two major groups that largely, though not perfectly, matched with their benign (WHO Grade I) or advanced (WHO Grades II and III) histological grade, with the latter exhibiting a significantly greater degree of genomic imbalance (P < 0.001). Sporadic multiple meningiomas showed a frequency of genomic imbalance events comparable to the atypical grade solitary tumors. By contrast, familial multiple meningiomas displayed no imbalances, supporting a distinct mechanism for the origin for these tumors.</p> <p>Conclusion</p> <p>Genomic profiling can provide an unbiased adjunct to traditional meningioma classification and provides a basis for exploring the different genetic underpinnings of tumor initiation and progression. Most importantly, the striking difference observed between sporadic and familial multiple meningiomas indicates that genomic profiling can provide valuable information for differential diagnosis of subjects with multiple meningiomas and for considering the risk for tumor occurrence in their family members.</p

Specific immunohistochemical localization of osteonectin and collagen types I and III in fetal and adult porcine dental tissues.

Affinity-purified antibodies have been used in combination with the peroxidase-antiperoxidase technique to study the distribution of osteonectin and collagen types I and III in porcine dental tissues. Tissue sections (2 mm thick), including unerupted (fetal) or erupted (adult) teeth, were fixed in periodate-lysine-paraformaldehyde, demineralized in 12% w/v ethylenediaminetetraacetic acid, and after embedding, 6 micron sections were prepared for immunolocalization. Strong staining for osteonectin was observed in dentine of unerupted teeth and in the associated alveolar bone. Light to moderate staining was observed in the dental pulp, stratum intermedium, stellate reticulum, and the reticular elements in the endosteal spaces. In erupted teeth, osteonectin staining in dentine was concentrated around dentinal tubules and the associated alveolar bone stained with variable intensity. Cementum was poorly stained. However, the periodontal ligament and reticular material in the endosteal spaces showed moderate to strong staining. Weaker staining was apparent in the pulp and lamina propria of the gingiva. In comparison, type I collagen showed a similar distribution to osteonectin in both fetal and adult tissues, whereas type III collagen was generally restricted to the periodontal ligament, reticular elements of the endosteal spaces, and Sharpey's fibers in bone and cementum. Both odontoblast and ameloblast layers in fetal tissues stained for osteonectin and type III collagen. </jats:p

Non Destructive Determination of the Threading Dislocation Density of Smooth Simox Substrates using Atomic Force Microscopy

Atomic force microscopy (AFM) has been used extensively in recent years to study the topographic nature of surfaces in the nanometer range. Its high resolution and ability to be automated have made it an indispensable tool in semiconductor fabrication. Traditionally, AFM has been used to monitor the surface roughness of substrates fabricated by separation by implanted oxygen (SIMOX) processes. It was during such monitoring that a novel use of AFM was uncovered.A SIMOX process requires two basic steps - a high dose oxygen ion implantation (1017 to 1018 cm-3) followed by a high temperature anneal (&gt;1200°C). The result of these processes is to form a buried oxide layer which isolates a top single crystal silicon layer from the underlying substrate. Pairs of threading dislocations can form in the top silicon layer during the high temperature anneal as a result of damage caused during the high dose oxygen implant.</jats:p

In reply to "Ways to improve outcome of decompressive craniectomy: judicious utilization of microneurosurgical technique adjuncts"

We read with interest the article “Measurement of bone flap surface area and midline shift to predict overall survival after decompressive craniectomy ”. 1 Decompressive craniectomy is associated with multitude of therapeutic effects including enlargement of the intracranial volume , re-opening up of perimesencephalic cisterns, improvement of cerebral compliance, increase in cerebral blood flow and cerebral perfusion, improvement of cerebrovascular regulation and reduction in midline shift, and intracranial pressure . However, outcome of decompressive craniectomy depends on various factors i.e. age of patient, primary intracranial pathology, size of decompressive craniectomy, preoperative midline shift, preoperative rise in intracranial pressure level, co-morbid illness, neurological status, mass effect and still controversy exists regarding size of decompressive craniectomy, optimal patient group, timings and surgical technique

Epidemiology of atrial fibrillation: European perspective

Massimo Zoni-Berisso, Fabrizio Lercari, Tiziana Carazza, Stefano DomenicucciDepartment of Cardiology, ASL 3, Padre A Micone Hospital, Genoa, ItalyAbstract: In the last 20 years, atrial fibrillation (AF) has become one of the most important public health problems and a significant cause of increasing health care costs in western countries. The prevalence of AF is increasing due to our greater ability to treat chronic cardiac and noncardiac diseases, and the improved ability to suspect and diagnose AF. At the present time, the prevalence of AF (2%) is double that reported in the last decade. The prevalence of AF varies with age and sex. AF is present in 0.12%&ndash;0.16% of those younger than 49 years, in 3.7%&ndash;4.2% of those aged 60&ndash;70 years, and in 10%&ndash;17% of those aged 80 years or older. In addition, it occurs more frequently in males, with a male to female ratio of 1.2:1. The incidence of AF ranges between 0.21 and 0.41 per 1,000 person/years. Permanent AF occurs in approximately 50% of patients, and paroxysmal and persistent AF in 25% each. AF is frequently associated with cardiac disease and comorbidities. The most common concomitant diseases are coronary artery disease, valvular heart disease, and cardiomyopathy. The most common comorbidities are hypertension, diabetes, heart failure, chronic obstructive pulmonary disease, renal failure, stroke, and cognitive disturbance. Paroxysmal AF occurs in younger patients and with a reduced burden of both cardiac disease and comorbidities. Generally, the history of AF is long, burdened by frequent recurrences, and associated with symptoms (in two thirds of patients). Patients with AF have a five-fold and two-fold higher risk of stroke and death, respectively. We estimate that the number of patients with AF in 2030 in Europe will be 14&ndash;17 million and the number of new cases of AF per year at 120,000&ndash;215,000. Given that AF is associated with significant morbidity and mortality, this increasing number of individuals with AF will have major public health implications.Keywords: atrial fibrillation, epidemiology, risk factors, mortality, strok