Characterization of an Inherited Neurologic Syndrome in Toyger Cats with Forebrain Commissural Malformations, Ventriculomegaly and Interhemispheric Cysts.

BackgroundIn children, frequent congenital malformations with concomitant agenesis of the corpus callosum are diagnosed by neuroimaging in association with other cerebral malformations, including interhemispheric cysts and ventriculomegaly. Similar studies providing full characterization of brain defects by in vivo magnetic resonance imaging (MRI), and correlations with the pertinent anatomic pathologic examinations are absent in veterinary medicine.Hypothesis/objectivesCongenital brain defects underlie the neurologic signs observed in Toyger cats selectively bred for a short ear phenotype.AnimalsUsing proper pedigree analysis and genetic evaluations, 20 related Oriental-derived crossbred Toyger cats were evaluated. Seven clinically healthy (carrier) cats and 13 clinically affected cats that had neurologic signs, short ear phenotype and concomitant complex brain anomalies were studied.MethodsComplete physical and neurologic examinations and MRI were performed in all clinically healthy and affected cats. Postmortem and histopathologic examinations were performed in 8 affected cats and 5 healthy cats.ResultsNeurologic and MRI investigations confirmed 13 clinically affected cats with structural brain abnormalities. Ventriculomegaly with frequent concomitant supratentorial interhemispheric, communicating ventricular type-1b cysts and multiple midline and callosal malformations were detected in all cats displaying neurologic signs. Genetic analysis confirmed autosomal recessive mode of inheritance with no chromosomal abnormalities.Conclusions and clinical importanceNeuroanatomic dissections and histopathology were helpful for evaluation of abnormalities in midline brain structures, and for the full characterization of cysts. However, MRI was more sensitive for detection of small cysts. In this feline model, MRI diagnosis had extremely good correlation with pathologic abnormalities noted in the subset of animals that were examined by both modalities

About the screening of the charge of a proton migrating in a metal

The amount of screening of a proton in a metal, migrating under the influence of an applied electric field, is calculated using different theoretical formulations. First the lowest order screening expression derived by Sham (1975) is evaluated. In addition 'exact' expressions are evaluated which were derived according to different approaches. For a proton in a metal modeled as a jellium the screening appears to be 15 +/- 10 %, which is neither negligible not reconcilable with the controversial full-screening point of view of Bosvieux and Friedel (1962). In reconsidering the theory of electromigration, a new simplified linear-response expression for the driving force is shown to lead to essentially the same result as found by Sorbello (1985), who has used a rather complicated technique. The expressions allow for a reduction such that only the scattering phase shifts of the migrating impurity are required. Finally it is shown that the starting formula for the driving force of Bosvieux and Friedel leads exactly to the zero-temperature limit of well-established linear response descriptions, by which the sting of the controversy has been removed.Comment: 14 pages, 5 figure

Evaluating the administration costs of biologic drugs: development of a cost algorithm.

Biologic drugs, as with all other medical technologies, are subject to a number of regulatory, marketing, reimbursement (financing) and other demand-restricting hurdles applied by healthcare payers. One example is the routine use of cost-effectiveness analyses or health technology assessments to determine which medical technologies offer value-for-money. The manner in which these assessments are conducted suggests that, holding all else equal, the economic value of biologic drugs may be determined by how much is spent on administering these drugs or trade-offs between drug acquisition and administration costs. Yet, on the supply-side, it seems very little attention is given to how manufacturing and formulation choices affect healthcare delivery costs. This paper evaluates variations in the administration costs of biologic drugs, taking care to ensure consistent inclusion of all relevant cost resources. From this, it develops a regression-based algorithm with which manufacturers could possibly predict, during process development, how their manufacturing and formulation choices may impact on the healthcare delivery costs of their products

A delay-dependent approach to H∞ filtering for stochastic delayed jumping systems with sensor non-linearities

This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2007 Taylor & Francis Ltd.In this paper, a delay-dependent approach is developed to deal with the stochastic H∞ filtering problem for a class of It type stochastic time-delay jumping systems subject to both the sensor non-linearities and the exogenous non-linear disturbances. The time delays enter into the system states, the sensor non-linearities and the external non-linear disturbances. The purpose of the addressed filtering problem is to seek an H∞ filter such that, in the simultaneous presence of non-linear disturbances, sensor non-linearity as well as Markovian jumping parameters, the filtering error dynamics for the stochastic time-delay system is stochastically stable with a guaranteed disturbance rejection attenuation level γ. By using It's differential formula and the Lyapunov stability theory, we develop a linear matrix inequality approach to derive sufficient conditions under which the desired filters exist. These conditions are dependent on the length of the time delay. We then characterize the expression of the filter parameters, and use a simulation example to demonstrate the effectiveness of the proposed results.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the U.K. under Grant GR/S27658/01, the Nuffield Foundation of the U.K.under Grant NAL/00630/G, and the Alexander von Humboldt Foundation of Germany

Discrete-choice modelling of patient preferences for modes of drug administration.

The administration of (biologically-derived) drugs for various disease conditions involves consumption of resources that constitutes a direct monetary cost to healthcare payers and providers. An often ignored cost relates to a mismatch between patients' preferences and the mode of drug administration. The "intangible" benefits of giving patients what they want in terms of the mode of drug delivery is seldom considered. This study aims to evaluate, in monetary terms, end-user preferences for the non-monetary attributes of different modes of drug administration using a discrete-choice experiment. It provides empirical support to the notion that there are significant benefits from developing patient-friendly approaches to drug delivery. The gross benefits per patient per unit administration is in the same order of magnitude as the savings in resource costs of administering drugs. The study argues that, as long as the underlying manufacturing science is capable, a patient-centred approach to producing drug delivery systems should be encouraged and pursued

D-brane orbiting NS5-branes

We study real time dynamics of a Dp-brane orbiting a stack of NS5-branes. It is generally known that a BPS D-brane moving in the vicinity of NS5-branes becomes unstable due to the presence of tachyonic degree of freedom induced on the D-brane. Indeed, the D-brane necessarily falls into the fivebranes due to gravitational attraction and eventually collapses into a pressureless fluid. Such a decay of the D-brane is known to be closely related to the rolling tachyon problem. In this paper we show that in special cases the decay of D-brane caused by gravitational attraction can be avoided. Namely for certain values of energy and angular momentum the D-brane orbits around the fivebranes, maintaining certain distance from the fivebranes all the time, and the process of tachyon condensation is suppressed. We show that the tachyonic degree of freedom induced on such a D-brane really disappears and the brane returns to a stable D-brane.Comment: 12 pages, latex, added referenc

Developing Business Architecture for SMEs: A Strategic Tool for Capability Orchestration and Managing Dynamisms

Small and Medium Enterprises (SMEs) are increasingly faced with competitive pressure due to swift and constant change to the dynamic and highly interconnected environment in which they operate. Competing in this dynamic ecosystem, SMEs need a strategic tool for managing co-evolution with the dynamic environment in order to create sustained value. Drawing from the specific SME characteristics operating in a collaborative network ecosystem of firms, this paper elicits the specific strategic management requirements that need to be satisfied by a Business Architecture. Extensive exploratory literature review and semi-structured interviews are used to explicate the underlying drivers of SME’s requirements for business architecture that need to be addressed by the requisite BA practice. The paper finds that, the BA practice must possess the capabilities to guide and assist the SMEs to adapt with the dynamic collaborative ecosystem of firms and sense, leverage and orchestrate the network of resources and ICT capabilities to create sustained value. This paper concludes with some guidelines for developing the business architecture-enabled journey toward creating sustained value within the said dynamic ecosystem

Long-Distance Wind-Dispersal of Spores in a Fungal Plant Pathogen: Estimation of Anisotropic Dispersal Kernels from an Extensive Field Experiment

Given its biological significance, determining the dispersal kernel (i.e., the distribution of dispersal distances) of spore-producing pathogens is essential. Here, we report two field experiments designed to measure disease gradients caused by sexually- and asexually-produced spores of the wind-dispersed banana plant fungus Mycosphaerella fijiensis. Gradients were measured during a single generation and over 272 traps installed up to 1000 m along eight directions radiating from a traceable source of inoculum composed of fungicide-resistant strains. We adjusted several kernels differing in the shape of their tail and tested for two types of anisotropy. Contrasting dispersal kernels were observed between the two types of spores. For sexual spores (ascospores), we characterized both a steep gradient in the first few metres in all directions and rare long-distance dispersal (LDD) events up to 1000 m from the source in two directions. A heavy-tailed kernel best fitted the disease gradient. Although ascospores distributed evenly in all directions, average dispersal distance was greater in two different directions without obvious correlation with wind patterns. For asexual spores (conidia), few dispersal events occurred outside of the source plot. A gradient up to 12.5 m from the source was observed in one direction only. Accordingly, a thin-tailed kernel best fitted the disease gradient, and anisotropy in both density and distance was correlated with averaged daily wind gust. We discuss the validity of our results as well as their implications in terms of disease diffusion and management strategy

Quantum field theoretic approach to neutrino oscillations in matter

We consider neutrino oscillations in non-uniform matter in a quantum field theoretic (QFT) approach, in which neutrino production, propagation and detection are considered as a single process. We find the conditions under which the oscillation probability can be sensibly defined and demonstrate how the properly normalized oscillation probability can be obtained in the QFT framework. We derive the evolution equation for the oscillation amplitude and discuss the conditions under which it reduces to the standard Schr\"odinger-like evolution equation. It is shown that, contrary to the common usage, the Schr\"odinger-like evolution equation is not applicable in certain cases, such as oscillations of neutrinos produced in decays of free pions provided that sterile neutrinos with $\Delta m^2\gtrsim 1$ eV$^2$ exist.Comment: LaTeX, 24 pages + 16 pages of appendices, 1 figure. V2: typos correcte