Swelling of particle-encapsulating random manifolds

We study the statistical mechanics of a closed random manifold of fixed area and fluctuating volume, encapsulating a fixed number of noninteracting particles. Scaling analysis yields a unified description of such swollen manifolds, according to which the mean volume gradually increases with particle number, following a single scaling law. This is markedly different from the swelling under fixed pressure difference, where certain models exhibit criticality. We thereby indicate when the swelling due to encapsulated particles is thermodynamically inequivalent to that caused by fixed pressure. The general predictions are supported by Monte Carlo simulations of two particle-encapsulating model systems -- a two-dimensional self-avoiding ring and a three-dimensional self-avoiding fluid vesicle. In the former the particle-induced swelling is thermodynamically equivalent to the pressure-induced one whereas in the latter it is not.Comment: 8 pages, 6 figure

Cosmological perturbations of self-accelerating universe in nonlinear massive gravity

We study cosmological perturbations of self-accelerating universe solutions in the recently proposed nonlinear theory of massive gravity, with general matter content. While the broken diffeomorphism invariance implies that there generically are 2 tensor, 2 vector and 2 scalar degrees of freedom in the gravity sector, we find that the scalar and vector degrees have vanishing kinetic terms and nonzero mass terms. Depending on their nonlinear behavior, this indicates either nondynamical nature of these degrees or strong couplings. Assuming the former, we integrate out the 2 vector and 2 scalar degrees of freedom. We then find that in the scalar and vector sectors, gauge-invariant variables constructed from metric and matter perturbations have exactly the same quadratic action as in general relativity. The difference from general relativity arises only in the tensor sector, where the graviton mass modifies the dispersion relation of gravitational waves, with a time-dependent effective mass. This may lead to modification of stochastic gravitational wave spectrum.Comment: 32 pages, 1 figure; v2: minor update to match the published versio

An Experimental Study of Reduced-Voltage Operation in Modern FPGAs for Neural Network Acceleration

We empirically evaluate an undervolting technique, i.e., underscaling the circuit supply voltage below the nominal level, to improve the power-efficiency of Convolutional Neural Network (CNN) accelerators mapped to Field Programmable Gate Arrays (FPGAs). Undervolting below a safe voltage level can lead to timing faults due to excessive circuit latency increase. We evaluate the reliability-power trade-off for such accelerators. Specifically, we experimentally study the reduced-voltage operation of multiple components of real FPGAs, characterize the corresponding reliability behavior of CNN accelerators, propose techniques to minimize the drawbacks of reduced-voltage operation, and combine undervolting with architectural CNN optimization techniques, i.e., quantization and pruning. We investigate the effect of environmental temperature on the reliability-power trade-off of such accelerators. We perform experiments on three identical samples of modern Xilinx ZCU102 FPGA platforms with five state-of-the-art image classification CNN benchmarks. This approach allows us to study the effects of our undervolting technique for both software and hardware variability. We achieve more than 3X power-efficiency (GOPs/W) gain via undervolting. 2.6X of this gain is the result of eliminating the voltage guardband region, i.e., the safe voltage region below the nominal level that is set by FPGA vendor to ensure correct functionality in worst-case environmental and circuit conditions. 43% of the power-efficiency gain is due to further undervolting below the guardband, which comes at the cost of accuracy loss in the CNN accelerator. We evaluate an effective frequency underscaling technique that prevents this accuracy loss, and find that it reduces the power-efficiency gain from 43% to 25%.Comment: To appear at the DSN 2020 conferenc

Effect of Gabapentin on Morphine Consumption and Pain after Surgical Debridement of Burn Wounds:A Double-Blind Randomized Clinical Trial Study

Background: Burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. Uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. Although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. The anticonvulsant gabapentin has been proven effective for treating neuropathic pain in large placebo-controlled clinical trials. Experimental and clinical studies have demonstrated antihyperalgesic effects in models with central neuronal sensitization. It has been suggested that central neuronal sensitization may play an important role in postoperative pain. Objectives: The aim of this study was to investigate the effect of gabapentin on morphine consumption and postoperative pain in burn patients undergoing resection of burn wounds. Patients and Methods: Results: All the enrolled patients were able to complete the study; therefore, data from 50 patients wereanalyzed. The VAS scores at rest andduring movement at 1,4,8,12,16,20, and 24 h after the operation were significantly lower in the gabapentin group than in the placebo group (P < 0.05). Morphine consumption was significantly lessr in the gabapentin group than in the placebo group (P < 0.05). Sedation scores were similar in the 2 groups at all measured times. There were no differences in adverse effects between the groups. Conclusions: A single oral dose of 1200mg gabapentin resulted in a substantial reduction in postoperative morphine consumption and pain scores after surgical debridement in burn patients

Definition of Time Induction of Self-Ignition of the Substance on the Prognostic Extrapolation Depending on the Basis of Indicators Fire and Explosion Hazard

In this article the research directed on development of a technique of definition of time of induction of the self-ignition of substances and materials which is an indicator of the beginning of development of an emergency is conducted. The experiment consisting in supervision over process of self-ignition of coal and oil deposits was the basis for research. On the basis of experimental data the curve expressing analytic - expected dependence of size of temperature of ignition on induction time was constructed. Proceeding from graphical representation of process, functional dependence of time of induction on a temperature indicator was received: y=16920•x{0.537}. By means of known indicators of such substances as bitumen oil oxidized (the combustible solid substance received by oxidation of residual product of oil refining) and tar oil (the combustible solid substance which is residual product of oil refining) and the received algorithm, verification of reliability of the received dependence and a technique of definition of time of induction of spontaneous ignition of deposits of oil in general was carried out. The practical importance of the conducted research is that having data on time of induction of process of self-ignition, by means of preventive measures becomes possible to avoid and prevent accidents in oil and oil processing branches, at the same time loss of property and loss of human life

Cigarette smoking worsens systemic inflammation in persons with metabolic syndrome

Background Emerging data suggests that the combination of smoking and metabolic syndrome (MetS) markedly increases cardiovascular disease risk well beyond that of either condition. In this study we assess if this interaction can be explained by an additive increase in the risk of systemic inflammation by MetS and cigarette smoking. Methods We evaluated 5,503 healthy non-diabetic Brazilian subjects (mean age of 43 ± 10 years, 79% males). Participants were divided into sub-groups of smokers and non-smokers with or without MetS. High-sensitivity C reactive protein (hs-CRP) was measured to assess degree of underlying inflammation. Results Overall (19%) had hs-CRP \u3e 3 mg/L. In adjusted regression analyses, compared to non-smokers, there was a 0.19 mg/L (95% CI: 0.05, 0.32) increase in hs-CRP among smokers in the entire population and 0.63 mg/L (95% CI: 0.26, 1.01) increase among smokers with MetS while there was no significant increase among smokers without MetS (β = 0.09 95% CI: -0.05, 0.24). In a fully adjusted logistic regression model, smokers compared to non-smokers were 55% more likely to have elevated hs-CRP in the entire population (OR 1.55, 95% CI: 1.25, 1.92) and more than twice as likely to have elevated hs-CRP if they had MetS ( OR 2.05, 95% CI: 1.40, 3.01) while the risk was non-significant among those without MetS (OR = 1.29, 95% CI: 0.98, 1.69). Conclusion The study demonstrates an additive effect of cigarette smoking on the risk of systemic inflammation in MetS thus highlighting the need for determining smoking status among those with MetS and aggressively targeting smoking cessation in this population

Inflationary perturbations in anisotropic backgrounds and their imprint on the CMB

We extend the standard theory of cosmological perturbations to homogeneous but anisotropic universes. We present an exhaustive computation for the case of a Bianchi I model, with a residual isotropy between two spatial dimensions, which is undergoing complete isotropization at the onset of inflation; we also show how the computation can be further extended to more general backgrounds. In presence of a single inflaton field, there are three physical perturbations (precisely as in the isotropic case), which are obtained (i) by removing gauge and nondynamical degrees of freedom, and (ii) by finding the combinations of the remaining modes in terms of which the quadratic action of the perturbations is canonical. The three perturbations, which later in the isotropic regime become a scalar mode and two tensor polarizations (gravitational wave), are coupled to each other already at the linearized level during the anisotropic phase. This generates nonvanishing correlations between different modes of the CMB anisotropies, which can be particularly relevant at large scales (and, potentially, be related to the large scale anomalies in the WMAP data). As an example, we compute the spectrum of the perturbations in this Bianchi I geometry, assuming that the inflaton is in a slow roll regime also in the anisotropic phase. For this simple set-up, fixing the initial conditions for the perturbations appears more difficult than in the standard case, and additional assumptions seem to be needed to provide predictions for the CMB anisotropies.Comment: 31 pages, 3 figure

Constraining the angular momentum evolution of V455 Andromedae

Time-series photometry on the cataclysmic variable V455 Andromedae (hereafter V455 And, HS 2331+3905) reveals a rotation period shorter than the orbital period, implying the presence of a magnetic field. We expect that this magnetic field channels the accreted matter from the disk toward the white dwarf poles, classifying it as an Intermediate Polar. The two polar spinning emission areas are visible in the lightcurves at the rotation period of 67.61970396 ± 0.00000072 s, and its harmonic. Using photometric observations of V455 And obtained from 2007 October to 2015, we derive 3σ upper limits to the rate of change of the spin harmonic (SH) with time to be dPSH/dt ≤ −7.5 × 10−15 s s−1 employing the O–C method, and −5.4 × 10−15 s s−1 with a direct nonlinear least squares fit. There is no significant detection of a changing spin period for the duration of 2007 October–2015. The 3σ upper limit for the rate of change of spin period with time is dPspin/dt ≤ −10.8 × 10−15 s s−1 or −0.34 μs yr−1. V455 And underwent a large-amplitude dwarf nova outburst in 2007 September. The pre-outburst data reflect a period 4.8 ± 2.2 μs longer than the best-fit post-outburst spin period. The angular momentum gained by the white dwarf from matter accreted during outburst and its slight subsequent shrinking should both cause the star to spin slightly faster after the outburst. We estimate that the change in spin period due to the outburst should be 5 μs, consistent with the empirical determination of 4.8 ± 2.2 μs (3σ upper limit of 11.4 μs)

Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia

Tuberous sclerosis (TS) is a common autosomal-dominant disorder characterized by tumors of the skin, lung, brain, and kidneys. Monotherapy with rapamycin however resulted in partial regression of tumors, implying the involvement of additional pathways. We have previously implicated platelet-derived growth factor-BB in TS-related tumorigenesis, thus providing a rationale for a combination of mTOR/PDGF blockade using rapamycin and imatinib. Here, we test this combination using a well-established preclinical model of cutaneous tumorigenesis in TS, tsc2ang1 cells derived from a skin tumor from a mouse heterozygous for tsc2. Treatment of tsc2ang1 cells with a combination of rapamycin and imatinib led to an inhibition of proliferation compared with either vehicle treatment or treatment with rapamycin or imatinib monotherapy. Combination therapy also led to a decrease in Akt activation. Potent in vivo activity in animal experiments by combination therapy was noted, without toxicity to the animals. Our findings provide a rationale for the combined use of rapamycin and imatinib, both FDA approved drugs, for the treatment of TS

Type Ibn Supernovae Show Photometric Homogeneity and Spectral Diversity at Maximum Light

Type Ibn supernovae (SNe) are a small yet intriguing class of explosions whose spectra are characterized by low-velocity helium emission lines with little to no evidence for hydrogen. The prevailing theory has been that these are the core-collapse explosions of very massive stars embedded in helium-rich circumstellar material (CSM). We report optical observations of six new SNe Ibn: PTF11rfh, PTF12ldy, iPTF14aki, iPTF15ul, SN 2015G, and iPTF15akq. This brings the sample size of such objects in the literature to 22. We also report new data, including a near-infrared spectrum, on the Type Ibn SN 2015U. In order to characterize the class as a whole, we analyze the photometric and spectroscopic properties of the full Type Ibn sample. We find that, despite the expectation that CSM interaction would generate a heterogeneous set of light curves, as seen in SNe IIn, most Type Ibn light curves are quite similar in shape, declining at rates around 0.1 mag day−1 during the first month after maximum light, with a few significant exceptions. Early spectra of SNe Ibn come in at least two varieties, one that shows narrow P Cygni lines and another dominated by broader emission lines, both around maximum light, which may be an indication of differences in the state of the progenitor system at the time of explosion. Alternatively, the spectral diversity could arise from viewing-angle effects or merely from a lack of early spectroscopic coverage. Together, the relative light curve homogeneity and narrow spectral features suggest that the CSM consists of a spatially confined shell of helium surrounded by a less dense extended wind