Evanescent incompressible strips as origin of the observed Hall resistance overshoot

In this work we provide a systematic explanation to the unusual non-monotonic behavior of the Hall resistance observed at two-dimensional electron systems. We use a semi-analytical model based on the interaction theory of the integer quantized Hall effect to investigate the existence of the anomalous, \emph{i.e} overshoot, Hall resistance $R_{H}$. The observation of the overshoot resistance at low magnetic field edge of the plateaus is elucidated by means of overlapping evanescent incompressible strips, formed due to strong magnetic fields and interactions. Utilizing a self-consistent numerical scheme we also show that, if the magnetic field is decreased the $R_{H}$ decreases to its expected value. The effects of the sample width, temperature, disorder strength and magnetic field on the overshoot peaks are investigated in detail. Based on our findings, we predict a controllable procedure to manipulate the maxima of the peaks, which can be tested experimentally. Our model does not depend on specific and intrinsic properties of the material, provided that a single particle gap exists.Comment: A theoretical follow-up paper of arXiv:1007.258

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocytes, where 5-lipoxygenase (5-LO) translocates to the nuclear envelope to assemble a functional complex with the integral nuclear membrane protein 5-LO-activating protein (FLAP). FLAP, a MAPEG family member, facilitates AA transfer to 5-LO for efficient conversion, and LT biosynthesis critically depends on FLAP. Here we show that the novel LT biosynthesis inhibitor BRP-187 prevents the 5-LO/FLAP interaction at the nuclear envelope of human leukocytes without blocking 5-LO nuclear redistribution. BRP-187 inhibited 5-LO product formation in human monocytes and polymorphonuclear leukocytes stimulated by lipopolysaccharide plus N-formyl-methionyl-leucyl-phenylalanine (IC50=7-10nM), and upon activation by ionophore A23187 (IC50=10-60nM). Excess of exogenous AA markedly impaired the potency of BRP-187. Direct 5-LO inhibition in cell-free assays was evident only at >35-fold higher concentrations, which was reversible and not improved under reducing conditions. BRP-187 prevented A23187-induced 5-LO/FLAP complex assembly in leukocytes but failed to block 5-LO nuclear translocation, features that were shared with the FLAP inhibitor MK886. Whereas AA release, cyclooxygenases and related LOs were unaffected, BRP-187 also potently inhibited microsomal prostaglandin E2 synthase-1 (IC50=0.2μM), another MAPEG member. In vivo, BRP-187 (10mg/kg) exhibited significant effectiveness in zymosan-induced murine peritonitis, suppressing LT levels in peritoneal exudates as well as vascular permeability and neutrophil infiltration. Together, BRP-187 potently inhibits LT biosynthesis in vitro and in vivo, which seemingly is caused by preventing the 5-LO/FLAP complex assembly and warrants further preclinical evaluation

Generalized Power Pompeiu Type Inequalities for Local Fractional Integrals with Applications to Ostrowski's Inequality

WOS: 000473350600021We establish some generalizations of power Pompeiu's inequality for local fractional integral. Afterwards, these results gave some new generalized Ostrowski type inequalities. Finally, some applications of these inequalities for generalized special means are obtained

Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy

FK506 (Tacrolimus) recently has been shown to be an effective immunosuppressant after renal transplantation. It is associated with less hypertension, hypercholesterolemia and steroid use compared with cyclosporine. We report 10 patients on FK506 who showed fibrin thrombi within the glomerular capillaries and/or arterioles at renal allograft biopsy. These biopsies were generally performed to assess increasing serum creatinine levels; laboratory evidence of hemolytic uremic syndrome was present in one instance. Plasma or whole blood FK506 levels were elevated in eight of 10 cases. Reduction of immunosuppression led to clinical improvement or biopsy- proven resolution of thrombi in all cases. These observations suggest that FK506 may occasionally produce microvascular changes in the renal allograft. The estimated incidence of this occurrence (1%) is comparable with that reported with cyclosporine (3%)

PERTURBED COMPANIONS OF OSTROWSKI TYPE INEQUALITIES FOR -TIMES DIFFERENTIABLE FUNCTIONS AND APPLICATIONS

We firstly examine some inequalities obtained by using sets of complex-valued functions for functions whose high order derivatives are restricted. We also give some approximations for the functions whose derivatives up to the order −1 ( ≥ 1) are continuous and whose the th derivatives are of bounded variation. So, the results provide extensions of those presented in earlier works

The partial oxidation of methane over Pd/Al2O3 catalyst nanoparticles studied in-situ by near ambient-pressure x-ray photoelectron spectroscopy

Near ambient-pressure X-ray photoelectron spectroscopy (NAP-XPS) is used to study the chemical state of methane oxidation catalysts in-situ. Al2O3{supported Pd catalysts are prepared with different particle sizes ranging from 4 nm to 10 nm. These catalysts were exposed to conditions similar to those used in the partial oxidation of methane (POM) to syn-gas and simultaneously monitored by NAP-XPS and mass spectrometry. NAP-XPS data show changes in the oxidation state of the palladium as the temperature in- creases, from metallic Pd0 to PdO, and back to Pd0. Mass spectrometry shows an increase in CO production whilst the Pd is in the oxide phase, and the metal is reduced back under presence of newly formed H2. A particle size effect is observed, such that CH4 conversion starts at lower temperatures with larger sized particles from 6 nm to 10 nm. We find that all nanoparticles begin CH4 conversion at lower temperatures than polycrystalline Pd foil

Real-time classification of multi-modal sensory data for prosthetic hand control

Recent work on myoelectric prosthetic control has shown that the incorporation of accelerometry information along with surface electromyography (sEMG) has the potential of improving the performance and robustness of a prosthetic device by increasing the classification accuracy. In this study, we investigated whether myoelectric control could further benefit from the use of additional sensory modalities such as gyroscopes and magnetometers. We trained a multi-class linear discriminant analysis (LDA) classifier to discriminate between six hand grip patterns and used predictions to control a robotic prosthetic hand in real-time. We recorded initial training data by using a total number of 12 sEMG sensors, each of which integrated a 9 degree-of-freedom inertial measurement unit (IMU). For classification, four different decoding schemes were used; 1) sEMG and IMU from all sensors 2) sEMG from all sensors, 3) IMU from all sensors and, finally, 4) sEMG and IMU from a nearly optimal subset of sensors. These schemes were evaluated based on offline classification accuracy on the training data, as well as with task-related metrics such as completion rates and times for a pick-and-place real-time experiment. We found that the classifier trained with all the sensory modalities and sensors (condition 1) attained the best decoding performance by achieving a 90.4% completion rate with an average completion time of 41.9 sec in real-time experiments. We also found that classifiers incorporating sEMG and IMU information outperformed on average the ones that only used sEMG signals, even when the amount of sensors used was less than half in the former case. These results suggest that using extra modalities along with sEMG might be more beneficial than including additional sEMG sensors