How should eosinophilic cystitis be treated in patients with chronic granulomatous disease?

Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from the absence or malfunction of oxidative mechanism in phagocytic cells. The disease is due to a mutation in one of four genes that encode subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Affected patients experience severe infections and granuloma formation due to exuberant inflammatory responses. Some evidence suggests that eosinophilic cystitis (EC) is included in the spectrum of inflammatory manifestations. EC is an inflammatory disease, rare in childhood, which may require different, nonstandardized therapeutic approaches, ranging from antihistamines to cyclosporine

Insights Into the Dynamics of Vegetated Alternate Bars by Means of Flume Experiments

Alternate bars are bedforms recognizable in straight or weakly curved channels as a result of riverbed instability. The length and height of alternate bars scale with the river width and the water depth, respectively. During low water stages, alternate bars become exposed and can be colonized by riparian vegetation. The effects of established plants on the morphodynamics of alternate bars have been poorly investigated. In this work, we focus on the effects induced by rigid vegetation on the dynamics and morphology of previously developed alternate bars in a straight channel by means of flume experiments. We investigate three different spatial densities of plants to reproduce scenarios of vegetation establishment. The results illustrate that vegetation alters both the altimetric and planimetric characteristics of bar patterns. In particular, as compared to bare-bed bars, vegetated bars have a higher wave amplitude and scour, and this effect becomes stronger with plant density. Moreover, they exhibit decreasing wavenumbers according to vegetation density. A comparison with previous fundamental work for the planimetric instability of straight channels with bare-bed alternate bars, suggests that the established vegetated bars may promote the transition to river meandering.PL-LCHLCH[1403

Pre-eruptive magmatic processes re-timed using a non-isothermal approach to magma chamber dynamics

Open Source PaperThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The attached file is the published version of the article

Equilibrium Cross Section of River Channels With Cohesive Erodible Banks

Predicting the equilibrium cross section of natural rivers has been widely investigated in fluvial morphology. Several approaches have been developed to meet this aim, starting from regime equations to the empirical formulations of Parker et al. (2007) and Wilkerson and Parker (2011), who proposed quasi-universal relations for describing bankfull conditions in sand and gravel bed rivers. Nevertheless, a general physics-based framework is still missing, and it remains an open issue to better clarify the basic mechanisms whereby a river selects its width. In this contribution we focus our attention on lowland rivers with cohesive banks, whose resistance to erosion is crucial to control the river width. In particular, we formulate a theoretical model that evaluates the equilibrium width of river cross sections modeling the interaction between the core flow in the central part of the section and the boundary layer that forms in the vicinity of the cohesive banks. The model computes the cross-section equilibrium configuration by which the shear stresses on the banks equal a critical threshold value. These stresses are computed by partitioning the total shear stress into an effective grain roughness component and a form component (Kean and Smith, 2006a). The model is applied to a large data set, concerning both sand and gravel bed rivers, and it is used to determine the relations expressing the channel width and the bankfull flow depth to the bankfull discharge, which appear to provide a unitary description of bankfull hydraulic geometry