An empirical investigation of transferring research to software technology innovation: a case of data-driven national security software

Context: Governments are providing more and more support for academia-industry collaborations for industry led research and innovation via Cooperative Research Centers (CRC). It is important to understand the processes and practices of such programs for transferring scientific R&D to innovation. Goal:We aimed at empirically investigating the processes and practices implemented in the context of one of the Australian CRCs, aimed at transferring big data research to innovative software solutions for national security. Method: We applied case study method and collected and analyzed data from 17 interviews and observations of the participants of the studied CRC program. Findings: We present the innovation process implemented in the studied CRC. We particularly highlight the practices used to involve end-users in the innovation process. We further elaborate on the challenges of running this collaborative model for software technology innovatio

Deep Imaging of AXJ2019+112: The Luminosity of a ``Dark Cluster''

We detect a distant cluster of galaxies centered on the QSO lens and luminous X-ray source AXJ2019+112, a.k.a. ``The Dark Cluster'' (Hattori et al 1997). Using deep V,I Keck images and wide-field K_s imaging from the NTT, a tight red sequence of galaxies is identified within a radius of 0.2 h^{-1} Mpc of the known z=1.01 elliptical lensing galaxy. The sequence, which includes the central elliptical galaxy, has a slope in good agreement with the model predictions of Kodama et al (1998) for z~1. We estimate the integrated rest-frame luminosity of the cluster to be L_V > 3.2 x 10^{11}h^{-2}L_{\sun} (after accounting for significant extinction at the low latitude of this field), more than an order of magnitude higher than previous estimates. The central region of the cluster is deconvolved using the technique of Magain, Courbin & Sohy (1998), revealing a thick central arc coincident with an extended radio source. All the observed lensing features are readily explained by differential magnification of a radio loud AGN by a shallow elliptical potential. The QSO must lie just outside the diamond caustic, producing two images, and the arc is a highly magnified image formed from a region close to the center of the host galaxy, projecting inside the caustic. The mass--to--light ratio within an aperture of 0.4 h ^{-1} Mpc is M_x/L_V= 224^{+112}_{-78}h(M/L_V)_{\sun}, using the X-ray temperature. The strong lens model yields a compatible value, M/L_V= 372^{+94}_{-94}h(M/L_V)_{\sun}, whereas an independent weak lensing analysis sets an upper limit of M/L_V <520 h(M/L_V)_{\sun}, typical of massive clusters.Comment: AAS Latex format, 24 pages, 9 figures. Fig 1a,b available at http://astro.berkeley.edu/~benitezn/cluster.html . Submitted to ApJ on August 15t

First e-VLBI observations of GRS 1915+105

We present results from the first successful open call e-VLBI science run, observing the X-ray binary GRS 1915+105. e-VLBI science allows the rapid production of VLBI radio maps, within hours of an observation rather than weeks, facilitating a decision for follow-up observations. A total of 6 telescopes observing at 5 GHz across the European VLBI Network (EVN) were correlated in real time at the Joint Institute for VLBI in Europe (JIVE). Constant data rates of 128 Mbps were transferred from each telescope, giving 4 TB of raw sampled data over the 12 hours of the whole experiment. Throughout this, GRS 1915+105 was observed for a total of 5.5 hours, producing 2.8 GB of visibilities of correlated data. A weak flare occurred during our observations, and we detected a slightly resolved component of 2.7 x 1.2 milliarcsecond with a position angle of 140 (+/-2) degrees. The peak brightness was 10.2 mJy per beam, with a total integrated radio flux of 11.1 mJy.Comment: Accepted for publication in MNRAS 4 pages, 3 figure

Constraining H0 from Chandra Observations of Q0957+561

We report the detection of the lens cluster of the gravitational lens (GL) system Q0957+561 from a deep observation with the Advanced CCD Imaging Spectrometer on-board the Chandra X-ray Observatory. Intracluster X-ray emission is found to be centered 4.3 +/- 1.3 arcsec east and 3.5(-0.6,+1.3) arcsec north of image B, nearer than previous estimates. Its spectrum can be modeled well with a thermal plasma model consistent with the emission originating from a cluster at a redshift of 0.36. Our best-fit estimates of the cluster temperature of T_e = 2.09(-0.54,+0.83) keV (90 percent confidence) and mass distribution of the cluster are used to derive the convergence parameter kappa, the ratio of the cluster surface mass density to the critical density required for lensing. We estimate the convergence parameter at the location of the lensed images A and B to be kappa_A = 0.22(+0.14,-0.07) and kappa_B = 0.21(+0.12,-0.07), respectively (90 percent confidence levels). The observed cluster center, mass distribution and convergence parameter kappa provide additional constraints to lens models of this system. Our new results break a mass-sheet degeneracy in GL models of this system and provide better constraints of ~ 29 percent (90 percent confidence levels) on the Hubble constant. We also present results from the detection of the most distant X-ray jet (z = 1.41) detected to date. The jet extends approximately 8 arcsec NE of image A and three knots are resolved along the X-ray jet with flux densities decreasing with distance from the core. The observed radio and optical flux densities of the knots are fitted well with a synchrotron model and the X-ray emission is modeled well with inverse Compton scattering of Cosmic Microwave Background photons by synchrotron-emitting electrons in the jet.Comment: 18 pages, includes 7 figures, Accepted for publication in Ap

Helical Jet in the Gravitationally Lensed Blazar PKS1830-211

Recent radio VLBI observations of the complex gravitationally lensed system PKS1830-211 have thrown up some questions with regard to the processes occuring at the heart of the blazar source at a redshift of 2.51, which is viewed almost straight down the jet axis. This work links, by a model of a helical jet tracked by ballistically ejected plasmons from a precessing nozzle, observations on the scale of tens of microarcseconds to those on the scale of milliarcseconds. An observed jet precession period of 1.08 years is inferred from the model, translating to an intrinsic period of 30.8 years for a source at redshift 2.51 and an assumed jet bulk velocity of 0.99 c. This fits well with the picture of an active galactic nucleus hosting a binary black hole system at its centre, with the jet emitted by one member of the system, and the precession as being due to its orbital motion around its companion.Comment: Accepted for publication in the MNRA

The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: A meta-analysis

Objective Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis. Data Sources We conducted a systematic review of the Cochrane Library, MEDLINE, EMBASE, CINAHL, conference proceedings, clinical practice guidelines, and other sources using a comprehensive strategy. Study Selection We identified randomized control trials comparing quantitative resuscitation with standard resuscitation in adult patients who were diagnosed with sepsis using standard criteria. The primary outcome variable was mortality. Data Abstraction Three authors independently extracted data and assessed study quality using standardized instruments; consensus was reached by conference. Preplanned subgroup analysis required studies to be categorized based on early (at the time of diagnosis) vs. late resuscitation implementation. We used the chi-square test and I2 to assess for statistical heterogeneity (p 25%). The primary analysis was based on the random effects model to produce pooled odds ratios with 95% confidence intervals. Results The search yielded 29 potential publications; nine studies were included in the final analysis, providing a sample of 1001 patients. The combined results demonstrate a decrease in mortality (odds ratio 0.64, 95% confidence interval 0.43–0.96); however, there was statistically significant heterogeneity (p = 0.07, I2 = 45%). Among the early quantitative resuscitation studies (n = 6) there was minimal heterogeneity (p = 0.40, I2 = 2.4%) and a significant decrease in mortality (odds ratio 0.50, 95% confidence interval 0.37–0.69). The late quantitative resuscitation studies (n = 3) demonstrated no significant effect on mortality (odds ratio 1.16, 95% confidence interval 0.60–2.22). Conclusion This meta-analysis found that applying an early quantitative resuscitation strategy to patients with sepsis imparts a significant reduction in mortality

Patient perspectives of managing fatigue in ankylosing spondylitis, and views on potential interventions: a qualitative study

&lt;p&gt;Background: Fatigue is a major component of living with ankylosing spondylitis (AS), though it has been largely over-looked, and currently there are no specific agreed management strategies.&lt;/p&gt; &lt;p&gt;Methods: This qualitative exploratory study involved participants who are members of an existing population-based ankylosing spondylitis (PAS) cohort. Participants residing in South West Wales were invited to participate in a focus group to discuss; (1) effects of fatigue, (2) self-management strategies and (3) potential future interventions. The focus groups were audio-recorded and the transcripts were analysed using thematic analysis.&lt;/p&gt; &lt;p&gt;Results: Participants consisted of 3 males/4 females (group 1) and 4 males/3 females (group 2), aged between 35 and 73 years (mean age 53 years). Three main themes were identified: (1) The effects of fatigue were multi-dimensional with participants expressing feelings of being ‘drained’ (physical), ‘upset’ (emotional) and experiencing ‘low-mood’ (psychological); (2) The most commonly reported self-management strategy for fatigue was a balanced combination of activity (exercise) and rest. Medication was reluctantly taken due to side-effects and worries over dependency; (3) Participants expressed a preference for psychological therapies rather than pharmacological for managing fatigue. Information on Mindfulness-Based Stress Reduction (MBSR) was received with interest, with recommendations for delivery in a group format with the option of distance-based delivery for people who were not able to attend a group course.&lt;/p&gt; &lt;p&gt;Conclusions: Patients frequently try and manage their fatigue without any formal guidance or support. Our research indicates there is a need for future research to focus on psychological interventions to address the multi-faceted aspects of fatigue in AS.&lt;/p&gt

Very High Angular Resolution Science with the Square Kilometre Array

Preliminary specifications for the Square Kilometre Array (SKA) call for 25% of the total collecting area of the dish array to be located at distances greater than 180 km from the core, with a maximum baseline of at least 3000 km. The array will provide angular resolution ~ 40 - 2 mas at 0.5 - 10 GHz with image sensitivity reaching < 50 nJy/beam in an 8 hour integration with 500 MHz bandwidth. Given these specifications, the high angular resolution component of the SKA will be capable of detecting brightness temperatures < 200 K with milliarcsecond-scale angular resolution. The aim of this article is to bring together in one place a discussion of the broad range of new and important high angular resolution science that will be enabled by the SKA, and in doing so, address the merits of long baselines as part of the SKA. We highlight the fact that high angular resolution requiring baselines greater than 1000 km provides a rich science case with projects from many areas of astrophysics, including important contributions to key SKA science.Comment: 13 pages, 6 figure

The Influence of Physiological Status on age Prediction of Anopheles Arabiensis Using Near Infra-red spectroscopy

Determining the age of malaria vectors is essential for evaluating the impact of interventions that reduce the survival of wild mosquito populations and for estimating changes in vectorial capacity. Near infra-red spectroscopy (NIRS) is a simple and non-destructive method that has been used to determine the age and species of Anopheles gambiae s.l. by analyzing differences in absorption spectra. The spectra are affected by biochemical changes that occur during the life of a mosquito and could be influenced by senescence and also the life history of the mosquito, i.e., mating, blood feeding and egg-laying events. To better understand these changes, we evaluated the influence of mosquito physiological status on NIR energy absorption spectra. Mosquitoes were kept in individual cups to permit record keeping of each individual insect’s life history. Mosquitoes of the same chronological age, but at different physiological stages, were scanned and compared using cross-validations. We observed a slight trend within some physiological stages that suggest older insects tend to be predicted as being physiologically more mature. It was advantageous to include mosquitoes of different chronological ages and physiological stages in calibrations, as it increases the robustness of the model resulting in better age predictions. Progression through different physiological statuses of An. arabiensis influences the chronological age prediction by the NIRS. Entomologists that wish to use NIR technology to predict the age of field-caught An. gambiae s.l from their study area should use a calibration developed from their field strain using mosquitoes of diverse chronological ages and physiological stages to increase the robustness and accuracy of the predictions.\u