Correlation functions and emission time sequence of light charged particles from projectile-like fragment source in E/A = 44 and 77 MeV 40Ar + 27Al collisions

Two-particle correlation functions, involving protons, deuterons, tritons, and alpha-particles, have been measured at very forward angles (0.7 deg < theta_lab < 7 deg), in order to study projectile-like fragment (PLF) emission in E/A = 44 and 77 MeV 40Ar + 27Al collisions. Peaks, originating from resonance decays, are larger at E/A = 44 than at 77 MeV. This reflects the larger relative importance of independently emitted light particles, as compared to two-particle decay from unstable fragments, at the higher beam energy. The time sequence of the light charged particles, emitted from the PLF, has been deduced from particle-velocity-gated correlation functions (discarding the contribution from resonance decays). Alpha-particles are found to have an average emission time shorter than protons but longer than tritons and deuterons.Comment: 18 pages, 5 figures, submitted to Nuclear Physics

Quantum corrections for pion correlations involving resonance decays

A method is presented to include quantum corrections into the calculation of two-pion correlations for the case where particles originate from resonance decays. The technique uses classical information regarding the space-time points at which resonances are created. By evaluating a simple thermal model, the method is compared to semiclassical techniques that assume exponential decaying resonances moving along classical trajectories. Significant improvements are noted when the resonance widths are broad as compared to the temperature.Comment: 9 pages, 4 figure

Quantum-Statistical Correlations and Single Particle Distributions for Slowly Expanding Systems with Temperature Profile

Competition among particle evaporation, temperature gradient and flow is investigated in a phenomenological manner, based on a simultaneous analysis of quantum statistical correlations and momentum distributions for a non-relativistic, spherically symmetric, three-dimensionally expanding, finite source. The parameters of the model emission function are constrained by fits to neutron and proton momentum distributions and correlation functions in intermediate energy heavy-ion collisions. The temperature gradient is related to the momentum dependence of the radius parameters of the two-particle correlation function, as well as to the momentum-dependent temperature parameter of the single particle spectrum, while a long duration of particle evaporation is found to be responsible for the low relative momentum behavior of the two-particle correlations.Comment: 20 pages + 5 ps figures, ReVTeX, uses psfig.sty, the description is extended to include final state interactions, phenomenological evaporation and to fit intermediate energy heavy ion proton and neutron spectrum and correlation dat

Gerstmann-Sträussler-Scheinker disease subtypes efficiently transmit in bank voles as genuine prion diseases.

Gerstmann-Sträussler-Scheinker disease (GSS) is an inherited neurodegenerative disorder associated with mutations in the prion protein gene and accumulation of misfolded PrP with protease-resistant fragments (PrPres) of 6–8 kDa

Upper Limit on the Prompt Muon Flux Derived from the LVD Underground Experiment

We present the analysis of the muon events with all muon multiplicities collected during 21804 hours of operation of the first LVD tower. The measured depth-angular distribution of muon intensities has been used to obtain the normalization factor, A, the power index, gamma, of the primary all-nucleon spectrum and the ratio, R_c, of prompt muon flux to that of pi-mesons - the main parameters which determine the spectrum of cosmic ray muons at the sea level. The value of gamma = 2.77 +/- 0.05 (68% C.L.) and R_c < 2.0 x 10^-3 (95% C.L.) have been obtained. The upper limit to the prompt muon flux favours the models of charm production based on QGSM and the dual parton model.Comment: 10 pages, 4 figures, RevTex. To appear in Phys. Rev.

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease

Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ultrasensitive immunoassay technology to demonstrate that NfL levels in the cerebrospinal fluid (n = 187) and serum (n = 405) are correlated with one another and are elevated at the presymptomatic stages of familial Alzheimer's disease. Longitudinal, within-person analysis of serum NfL dynamics (n = 196) confirmed this elevation and further revealed that the rate of change of serum NfL could discriminate mutation carriers from non-mutation carriers almost a decade earlier than cross-sectional absolute NfL levels (that is, 16.2 versus 6.8 years before the estimated symptom onset). Serum NfL rate of change peaked in participants converting from the presymptomatic to the symptomatic stage and was associated with cortical thinning assessed by magnetic resonance imaging, but less so with amyloid-β deposition or glucose metabolism (assessed by positron emission tomography). Serum NfL was predictive for both the rate of cortical thinning and cognitive changes assessed by the Mini-Mental State Examination and Logical Memory test. Thus, NfL dynamics in serum predict disease progression and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer's disease, which supports its potential utility as a clinically useful biomarker

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

A network of molecular chaperones is known to bind proteins ('clients') and balance their folding, function and turnover. However, it is often unclear which chaperones are critical for selective recognition of individual clients. It is also not clear why these key chaperones might fail in protein-aggregation diseases. Here, we utilized human microtubule-associated protein tau (MAPT or tau) as a model client to survey interactions between ~30 purified chaperones and ~20 disease-associated tau variants (~600 combinations). From this large-scale analysis, we identified human DnaJA2 as an unexpected, but potent, inhibitor of tau aggregation. DnaJA2 levels were correlated with tau pathology in human brains, supporting the idea that it is an important regulator of tau homeostasis. Of note, we found that some disease-associated tau variants were relatively immune to interactions with chaperones, suggesting a model in which avoiding physical recognition by chaperone networks may contribute to disease

Demand for the quality conservation of Venice, Italy, according to different nationalities.

This paper focuses on visitor demand for the quality conservation of Venice according to different nationalities. The vast majority of visitors to Venice are foreigners (both tourists and day-visitors) who come from all over the world. In this research they are mainly categorized as non-Italian Europeans or non-Europeans. A specific theoretical model, in which quality conservation is provided publicly and also privately through donations, is presented for nationals and for foreigners. The data are obtained from a contingent valuation survey carried out in Venice, the aim of which was to estimate visitors' willingness to donate (WTD) to the Venice flood defence programme. Demand functions are estimated by applying a twostage regression model. The authors show that the majority of visitors are willing to donate. On average, Italians and non-Europeans would donate more than non-Italian Europeans. As expected, these visitor categories have different mean WTD and different behavioural functions which are affected by attitudinal and economic variables. Bequest value is the main donation motive. Those who identify this as a donation motive, on average, state the highest WTD and the highest degree of certainty to donate. This result seems to confirm empirically the validity of the sustainable development principle applied to the management of Venice as a cultural tourist site