Effectiveness of the ADEC as a level 2 screening test for young children with suspected autism spectrum disorders in a clinical setting

Background The Autism Detection in Early Childhood (ADEC) is a clinician-administered, Level 2 screening tool. A retrospective file audit was used to investigate its clinical effectiveness. Method Toddlers referred to an Australian child development service between 2008 and 2010 (N?=?53, M age?=?32.2 months) were screened with the ADEC. Their medical records were reviewed in 2013 when their mean age was 74.5 months, and the original ADEC screening results were compared with later diagnostic outcomes. Results The ADEC had good sensitivity (87.5%) and moderate specificity (62%). Three behaviours predicted autism spectrum disorders (ASDs): response to name, gaze switching, and gaze monitoring (p???.001). Conclusions The ADEC shows promise as a screening tool that can discriminate between young children with ASDs and those who have specific communication disorders or developmental delays that persist into middle childhood but who do not meet the criteria for ASDs

Microwave saturation of the Rydberg states of electrons on helium

We present measurements of the resonant microwave excitation of the Rydberg energy levels of surface state electrons on superfluid helium. The temperature dependent linewidth agrees well with theoretical predictions and is very small below 300 mK. Absorption saturation and power broadening were observed as the fraction of electrons in the first excited state was increased to 0.49, close to the thermal excitation limit of 0.5. The Rabi frequency was determined as a function of microwave power. The high values of the ratio of the Rabi frequency to linewidth confirm this system as an excellent candidate for creating qubits.Comment: 4 pages, 4 figure

Intersubband plasmons in quasi-one-dimensional electron systems on a liquid helium surface

The collective excitation spectra are studied for a multisubband quasi-one-dimensional electron gas on the surface of liquid helium. Different intersubband plasmon modes are identified by calculating the spectral weight function of the electron gas within a 12 subband model. Strong intersubband coupling and depolarization shifts are found. When the plasmon energy is close to the energy differences between two subbands, Landau damping in this finite temperature system leads to plasmon gaps at small wavevectors.Comment: To be published as a Rapid Communication in Phys. Rev.

Electron transport in a quasi-one dimensional channel on suspended helium films

Quasi-one dimensional electron systems have been created using a suspended helium film on a structured substrate. The electron mobility along the channel is calculated by taking into account the essential scattering processes of electrons by helium atoms in the vapor phase, ripplons, and surface defects of the film substrate. It is shown that the last scattering mechanism may dominate the electron mobility in the low temperature limit changing drastically the temperature dependence of the mobility in comparison with that controlled by the electron-ripplon scattering.Comment: 4 pages, 1 figur

Strengthening impact assessment: a call for integration and focus

We suggest that the impact assessment community has lost its way based on our observation that impact assessment is under attack because of a perceived lack of efficiency. Specifically, we contend that the proliferation of different impact assessment types creates separate silos of expertise and feeds arguments for not only a lack of efficiency but also a lack of effectiveness of the process through excessive specialisation and a lack of interdisciplinary practice. We propose that the solution is a return to the basics of impact assessment with a call for increased integration around the goal of sustainable development and focus through better scoping. We rehearse and rebut counter arguments covering silo-based expertise, advocacy, democracy, sustainability understanding and communication. We call on the impact assessment community to rise to the challenge of increasing integration and focus, and to engage in the debate about the means of strengthening impact assessment

Magnetoresistance of nondegenerate quantum electron channels formed on the surface of superfluid helium

Transport properties of quasi-one-dimensional nondegenerate quantum wires formed on the surface of liquid helium in the presence of a normal magnetic field are studied using the momentum balance equation method and the memory function formalism. The interaction with both kinds of scatterers available (vapor atoms and capillary wave quanta) is considered. We show that unlike classical wires, quantum nondegenerate channels exhibit strong magnetoresistance which increases with lowering the temperature.Comment: 8 pages, 7 figure

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19). Control of the structure and function of the extracellular matrix (ECM) is a central theme of the biology of the ADAMTS, as exemplified by the actions of the procollagen-N-propeptidases in collagen fibril assembly and of the aggrecanases in the cleavage or modification of ECM proteoglycans. Defects in certain family members give rise to inherited genetic disorders, while the aberrant expression or function of others is associated with arthritis, cancer and cardiovascular disease. In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur. The basic ADAMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determining substrate specificity and the localization of the protease and its interaction partners; ancillary domains probably also have independent biological functions. Focusing primarily on the aggrecanases and proteoglycanases, this review provides a perspective on the evolution of the ADAMTS family, their links with developmental and disease mechanisms, and key questions for the future

The place of strategic environmental assessment in the privatised electricity industry

The private sector has given relatively little attention to the emergence of strategic environmental assessment (SEA); even recently privatised utilities, where SEA might be deemed particularly appropriate, and whose activities are likely to fall within the scope of the European Union SEA Directive, have shown less interest than might be expected. However, the global trend towards the privatisation of state-owned enterprises makes the adaptation of SEA towards these industries all the more pressing. This paper addresses the place that SEA might take within the electricity sector, taking the privatised UK electricity industry as an example. Particular challenges are posed by the radical restructuring of the industry, designed to introduce competitive behaviour, making the development of comprehensive SEA processes problematic, and requiring SEA to be placed in the context of corporate environmental policy and objectives.</p