A new regional climate model for POLAR-CORDEX : evaluation of a 30-year hindcast with COSMO-CLM2 over Antarctica

Continent-wide climate information over the Antarctic Ice Sheet (AIS) is important to obtain accurate information of present climate and reduce uncertainties of the ice sheet mass balance response and resulting global sea level rise to future climate change. In this study, the COSMO-CLM2 Regional Climate Model is applied over the AIS and adapted for the specific meteorological and climatological conditions of the region. A 30-year hindcast was performed and evaluated against observational records consisting of long-term ground-based meteorological observations, automatic weather stations, radiosoundings, satellite records, stake measurements and ice cores. Reasonable agreement regarding the surface and upper-air climate is achieved by the COSMO-CLM2 model, comparable to the performance of other state-of-the-art climate models over the AIS. Meteorological variability of the surface climate is adequately simulated, and biases in the radiation and surface mass balance are small. The presented model therefore contributes as a new member to the COordinated Regional Downscaling EXperiment project over the AIS (POLAR-CORDEX) and the CORDEX-CORE initiative

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury.

The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury. We have discovered a novel piperazine-derived compound, EVT901, which interferes with p75 neurotrophin receptor oligomerization through direct interaction with the first cysteine-rich domain of the extracellular region. Using ligand binding assays with cysteine-rich domains-fused p75 neurotrophin receptor, we confirmed that EVT901 interferes with oligomerization of full-length p75 neurotrophin receptor in a dose-dependent manner. Here we report that EVT901 reduces binding of pro-nerve growth factor to p75 neurotrophin receptor, blocks pro-nerve growth factor induced apoptosis in cells expressing p75 neurotrophin receptor, and enhances neurite outgrowth in vitro Furthermore, we demonstrate that EVT901 abrogates p75 neurotrophin receptor signalling by other ligands, such as prion peptide and amyloid-β. To test the efficacy of EVT901 in vivo, we evaluated the outcome in two models of traumatic brain injury. We generated controlled cortical impacts in adult rats. Using unbiased stereological analysis, we found that EVT901 delivered intravenously daily for 1 week after injury, reduced lesion size, protected cortical neurons and oligodendrocytes, and had a positive effect on neurological function. After lateral fluid percussion injury in adult rats, oral treatment with EVT901 reduced neuronal death in the hippocampus and thalamus, reduced long-term cognitive deficits, and reduced the occurrence of post-traumatic seizure activity. Together, these studies provide a new reagent for altering p75 neurotrophin receptor actions after injury and suggest that EVT901 may be useful in treatment of central nervous system trauma and other neurological disorders where p75 neurotrophin receptor signalling is affected

The Sources of Inflammatory Mediators in the Lung after Silica Exposure

The expression of 10 genes implicated in regulation of the inflammatory processes in the lung was studied after exposure of alveolar macrophages (AMs) to silica in vitro or in vivo. Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. AMs isolated after intratracheal instillation of silica up-regulated mRNA levels of four additional genes [granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-1β, IL-10, and inducible nitric oxide synthase]. IL-6, MCP-1, and MIP-2 protein levels were elevated in bronchoalveolar lavage fluid. Fibroblasts under basal culture conditions express much higher levels of IL-6 and GM-CSF compared with AMs. Coculture of AMs and alveolar type II cells, or coculture of AMs and lung fibroblasts, in contact cultures or Transwell chambers, revealed no synergistic effect. Therefore, such interaction does not explain the effects seen in vivo. Identification of the intercellular communication in vivo is still unresolved. However, fibroblasts appear to be an important source of inflammatory mediators in the lung

Evaluation of the CloudSat surface snowfall product over Antarctica using ground-based precipitation radars

In situ observations of snowfall over the Antarctic Ice Sheet are scarce. Currently, continent-wide assessments of snowfall are limited to information from the Cloud Profiling Radar on board the CloudSat satellite, which has not been evaluated up to now. In this study, snowfall derived from CloudSat is evaluated using three ground-based vertically profiling 24&thinsp;GHz precipitation radars (Micro Rain Radars: MRRs). Firstly, using the MRR long-term measurement records, an assessment of the uncertainty caused by the low temporal sampling rate of CloudSat (one revisit per 2.1 to 4.5 days) is performed. The 10–90th-percentile temporal sampling uncertainty in the snowfall climatology varies between 30&thinsp;% and 40&thinsp;% depending on the latitudinal location and revisit time of CloudSat. Secondly, an evaluation of the snowfall climatology indicates that the CloudSat product, derived at a resolution of 1∘ latitude by 2∘ longitude, is able to accurately represent the snowfall climatology at the three MRR sites (biases&thinsp;&lt;&thinsp;15&thinsp;%), outperforming ERA-Interim. For coarser and finer resolutions, the performance drops as a result of higher omission errors by CloudSat. Moreover, the CloudSat product does not perform well in simulating individual snowfall events. Since the difference between the MRRs and the CloudSat climatology are limited and the temporal uncertainty is lower than current Climate Model Intercomparison Project Phase 5 (CMIP5) snowfall variability, our results imply that the CloudSat product is valuable for climate model evaluation purposes.</p

What is the surface mass balance of Antarctica? An intercomparison of regional climate model estimates.

We compare the performance of five different regional climate models (RCMs) (COSMO-CLM2, HIRHAM5, MAR3.10, MetUM, and RACMO2.3p2), forced by ERA-Interim reanalysis, in simulating the near-surface climate and surface mass balance (SMB) of Antarctica. All models simulate Antarctic climate well when compared with daily observed temperature and pressure, with nudged models matching daily observations slightly better than free-running models. The ensemble mean annual SMB over the Antarctic ice sheet (AIS) including ice shelves is 2329±94 Gt yr−1 over the common 1987–2015 period covered by all models. There is large interannual variability, consistent between models due to variability in the driving ERA-Interim reanalysis. Mean annual SMB is sensitive to the chosen period; over our 30-year climatological mean period (1980 to 2010), the ensemble mean is 2483 Gt yr−1. However, individual model estimates vary from 1961±70 to 2519±118 Gt yr−1. The largest spatial differences between model SMB estimates are in West Antarctica, the Antarctic Peninsula, and around the Transantarctic Mountains. We find no significant trend in Antarctic SMB over either period. Antarctic ice sheet (AIS) mass loss is currently equivalent to around 0.5 mm yr−1 of global mean sea level rise (Shepherd et al., 2020), but our results indicate some uncertainty in the SMB contribution based on RCMs. We compare modelled SMB with a large dataset of observations, which, though biased by undersampling, indicates that many of the biases in SMB are common between models. A drifting-snow scheme improves modelled SMB on ice sheet surface slopes with an elevation between 1000 and 2000 m, where strong katabatic winds form. Different ice masks have a substantial impact on the integrated total SMB and along with model resolution are factored into our analysis. Targeting undersampled regions with high precipitation for observational campaigns will be key to improving future estimates of SMB in Antarctica

Evaluating precipitation in a regional climate model using ground-based radar measurements in Dronning Maud Land, East Antarctica

status: publishe

An Evaluation of Surface Climatology in State-of-the-Art Reanalyses over the Antarctic Ice Sheet

Abstract In this study, we evaluate output of near-surface atmospheric variables over the Antarctic Ice Sheet from four reanalyses: the new European Centre for Medium-Range Weather Forecasts ERA-5 and its predecessor ERA-Interim, the Climate Forecast System Reanalysis (CFSR), and the Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2). The near-surface temperature, wind speed, and relative humidity are compared with datasets of in situ observations, together with an assessment of the simulated surface mass balance (approximated by precipitation minus evaporation). No reanalysis clearly stands out as the best performing for all areas, seasons, and variables, and each of the reanalyses displays different biases. CFSR strongly overestimates the relative humidity during all seasons whereas ERA-5 and MERRA-2 (and, to a lesser extent, ERA-Interim) strongly underestimate relative humidity during winter. ERA-5 captures the seasonal cycle of near-surface temperature best and shows the smallest bias relative to the observations. The other reanalyses show a general temperature underestimation during the winter months in the Antarctic interior and overestimation in the coastal areas. All reanalyses underestimate the mean near-surface winds in the interior (except MERRA-2) and along the coast during the entire year. The winds at the Antarctic Peninsula are overestimated by all reanalyses except MERRA-2. All models are able to capture snowfall patterns related to atmospheric rivers, with varying accuracy. Accumulation is best represented by ERA-5, although it underestimates observed surface mass balance and there is some variability in the accumulation over the different elevation classes, for all reanalyses.</jats:p