Efficacy of a Novel Topical Combination of Fipronil 9.8% and (S)-Methoprene 8.8% against Ticks and Fleas in Naturally Infested Dogs

The efficacy of a novel topical combination of fipronil 9.8% (w/v) and (S)-methoprene 8.8% (w/v) (Fiprofort® Plus) was tested against ticks and fleas in naturally infested dogs. A total of fifty dogs were allocated in the study with ticks infestation (n=35) and fleas infestation (n=15). On day 0, thirty-five tick and fifteen flea infested dogs received the test formulation, a combination of fipronil 9.8% (w/v) and (S)-methoprene 8.8% (w/v) spot-on solution. Ticks and flea counts were taken on days 0 (pretreatment) and 3, 7, 14, 21, 28, and 35 after treatment. Blood samples were collected for evaluation of haematological parameters on days 0 (pretreatment) and 7, 21, and 35 after treatment. All the adult ticks and fleas collected were identified as Rhipicephalus sanguineus and Ctenocephalides felis, respectively. The efficacy of spot-on formulation against ticks was 34.00% (day 3), 53.14% (day 7), 62.71% (day 14), 65.48% (day 21), 59.80% (day 28), and 58.82% (day 35), whereas against fleas it was 38.00% (day 3), 64.34% (day 7), 89.67% (day 14), 95.40% (day 21), 100.00% (day 28), and 100.00% (day 35). Haematological parameters for ticks and fleas infested dogs were statistically nonsignificant as compared to control. The combination of fipronil and (S)-methoprene eliminated the existing ticks and fleas infestation and prevented the dogs from flea and tick infestation for four weeks

Prevalence of Pulmonary Hypertension in Dogs with Degenerative Mitral Valve Disease

The study was conducted to record the various clinical, electrocardiographic, radiographic and echocardiographic changes in dogs with Pulmonary Hypertension (PH) due to mitral valve disease (MVD). Among the MVD, dogs 15.5 per cent, 8.7 per cent and 4.8 per cent had mild PH, moderate PH and severe PH respectively. A highly significant increase in tricuspid regurgitation velocity (greater than 2.5 mm/Hg), tricuspid regurgitation peak gradient (greater than 25 mm Hg), was recorded in dogs with mild, moderate and severe PH due to MVD when compared to their disease control. A highly significant increase in of MPA/Ao (greater than 0.8) ratio was recorded in dogs with various degree of PH (mild, moderate and severe) when compared with dogs without PH. According to the severity tricuspid regurgitation flow pattern in the right atrium during systole was recorded in all these dogs. In dogs with MVD, moderate to severe PH worsens outcome.</jats:p

Gross Anatomical Study of Congenital Meningoencephalocoele and Craniofacial Deformities in A Kid

Background: Occurrence of congenital anomalies are less common in small ruminants, especially in goats compared to sheep. Most common cause for the congenital deformities in new born ruminants is due to the ingestion of toxic plants during gestation. Congenital meningoencephalocoele with associated craniofacial deformities is a rare occurrence in goats. Materials: A day old crossbred kid was presented with cranial defects and protrusion of brain through the defect. Detailed examination of the animal revealed cranioschisis in the frontal and parietal region along with presence of cleft lip, cleft palate and accessory ear lobe on the right side. Herniation of meninges and brain was exposed directly and was not covered by skin. There were two parietal cranial defects separated by a plate of bone. Result: Postmortem examination of the animal showed bilateral cleft lip and cleft palate with lateral deviation of nasal septum and deformation of premaxillary region. On reflection of skin over the frontal region, revealed frontal cranioschisis and the brain was situated subcutaneously. There were total of three cranial defects (two in the parietal and one in the frontal region) separated by small plates of bone in between them. This present study explains the anatomical aspects of cranioschisis, meningoencephalocoele, cleft lip, cleft palate and associated craniofacial abnormalities in a day old kid.</jats:p

Efficacy of a Novel Topical Combination of Fipronil 9.8% and (S)-Methoprene 8.8% against Ticks and Fleas in Naturally Infested Dogs

The efficacy of a novel topical combination of fipronil 9.8% (w/v) and (S)-methoprene 8.8% (w/v) (Fiprofort5 Plus) was tested against ticks and fleas in naturally infested dogs. A total of fifty dogs were allocated in the study with ticks infestation ( = 35) and fleas infestation ( = 15). On day 0, thirty-five tick and fifteen flea infested dogs received the test formulation, a combination of fipronil 9.8% (w/v) and (S)-methoprene 8.8% (w/v) spot-on solution. Ticks and flea counts were taken on days 0 (pretreatment) and 3, 7, 14, 21, 28, and 35 after treatment. Blood samples were collected for evaluation of haematological parameters on days 0 (pretreatment) and 7, 21, and 35 after treatment. All the adult ticks and fleas collected were identified as Rhipicephalus sanguineus and Ctenocephalides felis, respectively. The efficacy of spot-on formulation against ticks was 34.00% (day 3), 53.14% (day 7), 62.71% (day 14), 65.48% (day 21), 59.80% (day 28), and 58.82% (day 35), whereas against fleas it was 38.00% (day 3), 64.34% (day 7), 89.67% (day 14), 95.40% (day 21), 100.00% (day 28), and 100.00% (day 35). Haematological parameters for ticks and fleas infested dogs were statistically nonsignificant as compared to control. The combination of fipronil and (S)-methoprene eliminated the existing ticks and fleas infestation and prevented the dogs from flea and tick infestation for four weeks

Efficacy of a Novel Topical Combination of Fipronil 9.8% and (S)-Methoprene 8.8% against Ticks and Fleas in Naturally Infested Dogs

The efficacy of a novel topical combination of fipronil 9.8% (w/v) and (S)-methoprene 8.8% (w/v) (Fiprofort® Plus) was tested against ticks and fleas in naturally infested dogs. A total of fifty dogs were allocated in the study with ticks infestation (n=35) and fleas infestation (n=15). On day 0, thirty-five tick and fifteen flea infested dogs received the test formulation, a combination of fipronil 9.8% (w/v) and (S)-methoprene 8.8% (w/v) spot-on solution. Ticks and flea counts were taken on days 0 (pretreatment) and 3, 7, 14, 21, 28, and 35 after treatment. Blood samples were collected for evaluation of haematological parameters on days 0 (pretreatment) and 7, 21, and 35 after treatment. All the adult ticks and fleas collected were identified as Rhipicephalus sanguineus and Ctenocephalides felis, respectively. The efficacy of spot-on formulation against ticks was 34.00% (day 3), 53.14% (day 7), 62.71% (day 14), 65.48% (day 21), 59.80% (day 28), and 58.82% (day 35), whereas against fleas it was 38.00% (day 3), 64.34% (day 7), 89.67% (day 14), 95.40% (day 21), 100.00% (day 28), and 100.00% (day 35). Haematological parameters for ticks and fleas infested dogs were statistically nonsignificant as compared to control. The combination of fipronil and (S)-methoprene eliminated the existing ticks and fleas infestation and prevented the dogs from flea and tick infestation for four weeks