Density of states in graphene with vacancies: midgap power law and frozen multifractality

The density of states (DoS), $\varrho(E)$, of graphene is investigated numerically and within the self-consistent T-matrix approximation (SCTMA) in the presence of vacancies within the tight binding model. The focus is on compensated disorder, where the concentration of vacancies, $n_\text{A}$ and $n_\text{B}$, in both sub-lattices is the same. Formally, this model belongs to the chiral symmetry class BDI. The prediction of the non-linear sigma-model for this class is a Gade-type singularity $\varrho(E) \sim |E|^{-1}\exp(-|\log(E)|^{-1/x})$. Our numerical data is compatible with this result in a preasymptotic regime that gives way, however, at even lower energies to $\varrho(E)\sim E^{-1}|\log(E)|^{-\mathfrak{x}}$, $1\leq \mathfrak{x} < 2$. We take this finding as an evidence that similar to the case of dirty d-wave superconductors, also generic bipartite random hopping models may exhibit unconventional (strong-coupling) fixed points for certain kinds of randomly placed scatterers if these are strong enough. Our research suggests that graphene with (effective) vacancy disorder is a physical representative of such systems.Comment: References updated onl

Detection of a period decrease in NN Ser with ULTRACAM: evidence for strong magnetic braking or an unseen companion?

We present results of high time resolution photometry of the eclipsing pre-cataclysmic variable NN Ser. We observed 13 primary eclipses of NN Ser using the high-speed CCD camera ULTRACAM and derived times of mid-eclipse, from fitting of light curve models, with uncertainties as low as 0.06 s. The observed rates of period change appear difficult to reconcile with any models of orbital period change. If the observed period change reflects an angular momentum loss, the average loss rate is consistent with the loss rates (via magnetic stellar wind braking) used in standard models of close binary evolution, which were derived from observations of much more massive cool stars. Observations of low-mass stars such as NN Ser's secondary predict rates of ~100 times lower than we observe. We show that magnetic activity-driven changes in the quadrupole moment of the secondary star (Applegate, 1992) fail to explain the period change by an order of magnitude on energetic grounds, but that a light travel time effect caused by the presence of a third body in a long (~ decades) orbit around the binary could account for the observed changes in the timings of NN Ser's mid-eclipses. We conclude that we have either observed a genuine angular momentum loss for NN Ser, in which case our observations pose serious difficulties for the theory of close binary evolution, or we have detected a previously unseen low-mass companion to the binary.Comment: 10 pages, 6 figures. Accepted for publication in MNRA

MiX: A Position Sensitive Dual-Phase Liquid Xenon Detector

The need for precise characterization of dual-phase xenon detectors has grown as the technology has matured into a state of high efficacy for rare event searches. The Michigan Xenon detector was constructed to study the microphysics of particle interactions in liquid xenon across a large energy range in an effort to probe aspects of radiation detection in liquid xenon. We report the design and performance of a small 3D position sensitive dual-phase liquid xenon time projection chamber with high light yield ($L_y^{122}=15.2$pe/keV at zero field), long electron lifetime ($\tau > 200 \mu$s), and excellent energy resolution ($\sigma/E = 1\%$ for 1,333 keV gamma rays in a drift field of 200 V/cm). Liquid xenon time projection chambers with such high energy resolution may find applications not only in dark matter direct detection searches, but also in neutrinoless double beta decay experiments and other applications.Comment: 18 pages, 13 figures, and 2 table

Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients

Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and after remission. Results: Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective genotypes, the stress hormones remained elevated in the second DEX/CRH test, despite a reduction in depressive symptoms. Conclusions: This study provides evidence that, depending on gender and polymorphisms, there is continuous HPA axis overdrive in a proportion of patients irrespective of the status of depression. Considering the importance of stress hormones for cardiovascular disorders, our data might suggest that these patients are at high risk of comorbidity between depression and cardiovascular disorders. Copyright (c) 2008 S. Karger AG, Base

Precise mass and radius values for the white dwarf and low mass M dwarf in the pre-cataclysmic binary NN Serpentis

We derive precise system parameters for the pre-cataclysmic binary, NN Ser. From light curve fitting we find an orbital inclination of i = 89.6 +/- 0.2 deg. From the HeII absorption line we find K_{WD}= 62.3 +/- 1.9 km/s. The irradiation-induced emission lines from the surface of the secondary star give a range of observed radial velocities. The corrected values give a radial velocity of K_{sec}= 301 +/- 3 km/s, with an error dominated by the systematic effects of the model. This leads to a binary separation of a = 0.934 +/- 0.009 R_{sun}, radii of R_{WD} = 0.0211 +/- 0.0002 R_{sun} and R_{sec} = 0.149 +/- 0.002 R_{sun} and masses of M_{WD} = 0.535 +/- 0.012 M_{sun} and M_{sec} = 0.111 +/- 0.004 M_{sun}. The masses and radii of both components of NN Ser were measured independently of any mass-radius relation. For the white dwarf, the measured mass, radius and temperature show excellent agreement with a `thick' hydrogen layer of fractional mass M_{H}/{M}_{WD} = 10^{-4}. The measured radius of the secondary star is 10% larger than predicted by models, however, correcting for irradiation accounts for most of this inconsistency, hence the secondary star in NN Ser is one of the first precisely measured very low mass objects to show good agreement with models. ULTRACAM r', i' and z' photometry taken during the primary eclipse determines the colours of the secondary star as (r'-i')_{sec}= 1.4 +/- 0.1 and (i'-z')_{sec} = 0.8 +/- 0.1 which corresponds to a spectral type of M4 +/- 0.5. This is consistent with the derived mass, demonstrating that there is no detectable heating of the unirradiated face, despite intercepting radiative energy from the white dwarf which exceeds its own luminosity by over a factor of 20.Comment: 20 pages, 17 figures, 8 tables, minor changes, accepted for publication in MNRA

Astroclimatic Characterization of Vallecitos: A candidate site for the Cherenkov Telescope Array at San Pedro Martir

We conducted an 18 month long study of the weather conditions of the Vallecitos, a proposed site in Mexico to harbor the northern array of the Cherenkov Telescope Array (CTA). It is located in Sierra de San Pedro Martir (SPM) a few kilometers away from Observatorio Astron\'omico Nacional. The study is based on data collected by the ATMOSCOPE, a multi-sensor instrument measuring the weather and sky conditions, which was commissioned and built by the CTA Consortium. Additionally, we compare the weather conditions of the optical observatory at SPM to the Vallecitos regarding temperature, humidity, and wind distributions. It appears that the excellent conditions at the optical observatory benefit from the presence of microclimate established in the Vallecitos.Comment: 16 pages, 16 figures, Publication of the Astronomical Society of the Pacific, accepte

The planets around NN Serpentis : still there

We present 25 new eclipse times of the white dwarf binary NN Ser taken with the high-speed camera ULTRACAM on the William Herschel Telescope and New Technology Telescope, the RISE camera on the Liverpool Telescope and HAWK-I on the Very Large Telescope to test the two-planet model proposed to explain variations in its eclipse times measured over the last 25 yr. The planetary model survives the test with flying colours, correctly predicting a progressive lag in eclipse times of 36 s that has set in since 2010 compared to the previous 8 yr of precise times. Allowing both orbits to be eccentric, we find orbital periods of 7.9 ± 0.5 and 15.3 ± 0.3 yr, and masses of 2.3 ± 0.5 and 7.3 ± 0.3 MJ. We also find dynamically long-lived orbits consistent with the data, associated with 2:1 and 5:2 period ratios. The data scatter by 0.07 s relative to the best-fitting model, by some margin the most precise of any of the proposed eclipsing compact object planet hosts. Despite the high precision, degeneracy in the orbit fits prevents a significant measurement of a period change of the binary and of N-body effects. Finally, we point out a major flaw with a previous dynamical stability analysis of NN Ser, and by extension, with a number of analyses of similar systems

Interparticle interactions:Energy potentials, energy transfer, and nanoscale mechanical motion in response to optical radiation

In the interactions between particles of material with slightly different electronic levels, unusually large shifts in the pair potential can result from photoexcitation, and on subsequent electronic excitation transfer. To elicit these phenomena, it is necessary to understand the fundamental differences between a variety of optical properties deriving from dispersion interactions, and processes such as resonance energy transfer that occur under laser irradiance. This helps dispel some confusion in the recent literature. By developing and interpreting the theory at a deeper level, one can anticipate that in suitable systems, light absorption and energy transfer will be accompanied by significant displacements in interparticle separation, leading to nanoscale mechanical motion

DE Canum Venaticorum : a bright, eclipsing red dwarf–white dwarf binary

Context. Close white dwarf–red dwarf binaries must have gone through a common-envelope phase during their evolution. DE CVn is a detached white dwarf–red dwarf binary with a relatively short (∼8.7 h) orbital period. Its brightness and the presence of eclipses makes this system ideal for a more detailed study. Aims. From a study of photometric and spectroscopic observations of DE CVn we derive the system parameters that we discuss in the framework of common-envelope evolution. Methods. Photometric observations of the eclipses are used to determine an accurate ephemeris. From a model fit to an average lowresolution spectrum of DE CVn, we constrain the temperature of the white dwarf and the spectral type of the red dwarf. The eclipse light curve is analysed and combined with the radial velocity curve of the red dwarf determined from time-resolved spectroscopy to derive constraints on the inclination and the masses of the components in the system. Results. The derived ephemeris is HJDmin = 2 452 784.5533(1) + 0.3641394(2) × E. The red dwarf in DE CVn has a spectral type of M3V and the white dwarf has an effective temperature of 8 000 K. The inclination of the system is 86+3◦ −2 and the mass and radius of the red dwarf are 0.41 ± 0.06 M and 0.37+0.06 −0.007 R, respectively, and the mass and radius of the white dwarf are 0.51+0.06 −0.02 M and 0.0136+0.0008 −0.0002 R, respectively. Conclusions. We found that the white dwarf has a hydrogen-rich atmosphere (DA-type). Given that DE CVn has experienced a common-envelope phase, we can reconstruct its evolution and we find that the progenitor of the white dwarf was a relatively lowmass star (M ≤ 1.6 M). The current age of this system is 3.3−7.3 × 109 years, while it will take longer than the Hubble time for DE CVn to evolve into a semi-detached system

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity

The conditionally replicating oncolytic adenovirus Delta24-RGD (Ad) is currently under investigation in clinical trials for glioblastoma, including in combination with temozolomide (TMZ), the standard chemotherapy for this tumor. Previously, we showed that the efficacy of Delta24-RGD in a murine model is primarily dependent on the virus-induced anti-tumor immune response. As observed with most chemotherapies, TMZ has pronounced immune-modulating effects. Here, we studied the combined effects of these treatments in a murine glioma model. In vitro, we observed a synergistic activity between Delta24-RGD and TMZ. In vivo, C57BL/6 mice bearing intracranial GL261 tumors were treated with TMZ for 5 days either prior to intratumoral Delta24-RGD injection (TMZ/Ad) or post virus injection (Ad/TMZ). Notably, the Ad/TMZ regimen led to similar tumoral CD8+ T cell influx as the virus-only treatment, but increased the ability of CD8+ T cells to specifically recognize the tumor cells. This was accompanied by improved survival. The TMZ/Ad regimen also improved survival significantly compared to controls, but not compared to virus alone. In this group, the influx of dendritic cells is impaired, followed by a significantly lower number of tumor-infiltrating CD8+ T cells and no recognition of tumor cells. Depletion of either CD4+ T cells or CD8+ T cells impaired the efficacy of Delta24-RGD, underscoring the role of these cells in therapeutic activity of the virus. Overall, we show that the addition of TMZ to Delta24-RGD treatment leads to a significant increase in survival and that the order of sequence of these treatments affects the CD8+T cell anti-tumor activity