Comparative Study of the Interaction of Polyoma and Other Hemagglutinating Viruses with an Isolated Bovine Mucoprotein

Summary A number of hemagglutinating viruses were compared with polyoma virus for their ability to react with mucoprotein isolated from bovine serum. Hemagglutination by polyoma and mumps viruses and the PR8, A/57, swine, and Tokyo B strains of influenza virus was inhibited by the mucoprotein, whereas that of Sendai, Newcastle disease, ECHO (3, 9, 10, 11) viruses, and the A/53, C, and Lee strains of influenza virus were not. The characteristics of the various viral hemagglutination reactions were compared with the corresponding reactions between virus and mucoprotein. The temperature sensitive, reversible hemagglutination reaction of polyoma virus, could be accounted for in terms of the nature of the complex it forms with mucoprotein.</jats:p

Some Properties of an Inhibitor of Polyoma Virus Hemagglutination Isolated from Bovine Serum

Summary One of the several substances found in bovine serum which prevent agglutination of erythrocytes by polyoma virus has been isolated. The kinetics of its action indicate it reacts with the virus to form a product whose stability only at low temperature closely resembles the virus-erythrocyte complex. Like the red cell receptor, it is a mucoprotein. Some of its chemical and physical characteristics, as well as its visualization in the electron microscope, are described.</jats:p