The definition of recurrent shoulder dislocation in tramadol induced seizure patients

Background: Prevalence of recurrent shoulder dislocation in patients taking tramadol has not been studied yet; so, this study aims to study the recurrent shoulder dislocation following tramadol induced seizure. Methods: In this cross-sectional study, 205 patients with recurrent shoulder dislocation complaints (2 or more) referred to Shafa Orthopedic and Iranmehr hospitals Tehran, Iran, from October 2012 to October 2014 were studied. Data on patient history and physical examination, patient demographic information such as age, sex, age at first dislocation, total number of dislocation, cause of the first dislocation, history of tramadol use, number of dislocation following tramadol induced seizure, history of other drugs use, the dominant hand, involved side, direction of dislocations and greater tuberosity fracture was recorded using a pre-designed questionnaire. Categorical variables were compared by chi-square test and the means were compared with student T-test. Results: In this study, 50 patients (24.4) suffered from tramadol induced seizures and recurrent shoulder dislocation. Results showed that there was a significant relationship between the number of dislocation and tramadol use (P = 0.02). Recurrent shoulder dislocation following tramadol induced seizure was significantly associated with greater tuberosity fracture of humerus (P = 0.04); in 49 out of 50 patients (98) dislocation was of anterior type. Conclusion: The findings of this study suggest that tramadol induced seizure may increase the risk of recurrent shoulder dislocation. Furthermore, the prevalence of greater tuberosity fracture in shoulder dislocation increases following tramadol induced seizure; and anterior shoulder dislocation is the most common type of dislocation following tramadol induced seizure

Does individual-specific strength training have an effect upon knee muscle strength balances? Knee muscle strength balances

Objectives: The purpose of the study was to investigate the effect of 8-week individual-specific strength exercises on knee muscle strength balance. Methods: Totally 42 male voluntary amateur soccer players participated in the study. The players were categorized into 3 groups with 14 members in each one; the control group (CG), maximal strength training group (STG) and individual-specific strength training group (ISTG). The players in both STG and ISTG performed strength exercises for lower extremity for 3 days per week for 8 weeks. Dominant (D) and non-dominant (ND) leg concentric extension and concentric flexion of the players were determined by means of isokinetic dynamometer called 'Biodex' at 60 degrees s(-1), 180 degrees s(-1) and 300 degrees s(-1) angular velocities. Wilcoxon test was conducted to determine the differences between pretest and post-test of the groups. Results: Dominant and non-dominant leg H/Q ratio was specified to increase in ISTG at 60 degrees s(-1), 180 degrees s(-1) and 300 degrees s(-1) angular velocities (p<0.05). Although no statistically significant difference was found in terms of bilateral deficit in any groups, BLD was noticed to decrease significantly in dominant and non-dominant legs in ISTG group. Conclusions: As a result, it was determined that in STG and ISTG considering the strength deficits of the athletes was to increase the H/Q ratio and reduce BLD, yet the H/Q ratios and BLD yielded a better improvement in ISTG, and thus leading a more effective method in individual training.Nigde Omer Halisdemir University, 'Scientific Research Projects Department'We would like to thank Nigde Omer Halisdemir University, 'Scientific Research Projects Department' for the support to this study

New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours.

The latest (4th) edition of the World Health Organization Classification of Head and Neck tumours has recently been published with a number of significant changes across all tumour sites. In particular, there has been a major attempt to simplify classifications and to use defining criteria which can be used globally in all situations, avoiding wherever possible the use of complex molecular techniques which may not be affordable or widely available. This review summarises the changes in Chapter 8: Odontogenic and maxillofacial bone lesions. The most significant change is the re-introduction of the classification of the odontogenic cysts, restoring this books status as the only text which classifies and defines the full range of lesions of the odontogenic tissues. The consensus group considered carefully the terminology of lesions and were concerned to ensure that the names used properly reflected the best evidence regarding the true nature of specific entities. For this reason, this new edition restores the odontogenic keratocyst and calcifying odontogenic cyst to the classification of odontogenic cysts and rejects the previous terminology (keratocystic odontogenic tumour and calcifying cystic odontogenic tumour) which were intended to suggest that they are true neoplasms. New entities which have been introduced include the sclerosing odontogenic carcinoma and primordial odontogenic tumour. In addition, some previously poorly defined lesions have been removed, including the ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, which are probably developing odontomas, and the odontoameloblastoma, which is not regarded as an entity. Finally, the terminology "cemento" has been restored to cemento-ossifying fibroma and cemento-osseous dysplasias, to properly reflect that they are of odontogenic origin and are found in the tooth-bearing areas of the jaws

How Nigeria’s 2015 presidential election outcome was forecasted with geodemographics and public sentiment analytics

In 2015, Nigeria held one of the most fiercely contested presidential elections in the nation’s recent democratic history. The outcome of the election was expected to exert significant influence on democratic practices on the African continent. The stiffness of the contest also meant that it was difficult to predict the likely winner of the election. This paper summarizes how an empirical approach was used to forecast the outcome of the election by modeling public sentiment data-set using a geodemographic framework. Results indicate that the main electorates that determined the outcome of the election were situated in thirteen battleground states. Additionally, results showed that two years before the presidential election, Goodluck Jonathan’s public approval ratings on corruption, insecurity, and the economy (the main drivers of the 2015 election) had nose-dived across many of the battleground states. This eventually contributed toward his loss

Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial

The multimodal activities of farnesoid X receptor (FXR) agonists make this class an attractive option to treat nonalcoholic steatohepatitis. The safety and efficacy of tropifexor, an FXR agonist, in a randomized, multicenter, double-blind, three-part adaptive design, phase 2 study, in patients with nonalcoholic steatohepatitis were therefore assessed. In Parts A + B, 198 patients were randomized to receive tropifexor (10–90 μg) or placebo for 12 weeks. In Part C, 152 patients were randomized to receive tropifexor 140 µg, tropifexor 200 µg or placebo (1:1:1) for 48 weeks. The primary endpoints were safety and tolerability to end-of-study, and dose response on alanine aminotransferase (ALT), aspartate aminotransferase (AST) and hepatic fat fraction (HFF) at week 12. Pruritus was the most common adverse event in all groups, with a higher frequency in the 140- and 200-µg tropifexor groups. Decreases from baseline in ALT and HFF were greater with tropifexor versus placebo at week 12, with a relative decrease in least squares mean from baseline observed with all tropifexor doses for ALT (tropifexor 10–90-μg dose groups ranged from −10.7 to −16.5 U l−1 versus placebo (−7.8 U l−1) and tropifexor 140- and 200-μg groups were −18.0 U l−1 and −23.0 U l−1, respectively, versus placebo (−8.3 U l−1)) and % HFF (tropifexor 10–90-μg dose groups ranged from −7.48% to −15.04% versus placebo (−6.19%) and tropifexor 140- and 200-μg groups were −19.07% and −39.41%, respectively, versus placebo (−10.77%)). Decreases in ALT and HFF were sustained up to week 48; however, similar trends in AST with tropifexor at week 12 were not observed. As with other FXR agonists, dose-related pruritus was frequently observed. Clinicaltrials.gov registration: NCT02855164

Study of penculture of the common carp (Cyprinus carpio L.) fingerlings at the Gorgan Bay to the maturity stage (broodstock management)

The aim of present project is study on the possibilities of brood stock production from fingerlings in the penculture condition and the effect of density on it .this project was done during three years with two different treatment and three repetitions in the Gorgan Bay. First treatment with two fingerlings per square meter and the 2nd with four fingerlings per square meter in each pen.To carry out the project at first fingerlings were brought from breeding and recruitment centre –Sijeval (Kolmeh) and the stocked at the earthen pound with concentrated food .After that they were adaptated with brakish water between 7-10 days and transferred to Gorgan Bay for cultivation with average weight of 93.78±32.66 grams and 20.53±2.37 cm in length. It should be noted that 6 pens (which surrounded by nets in the water) were fixed using mast with 15-20 cm in diameter and 5.5 meter in length , Net mesh size was 16 mm with string number 33 of kapron.Feeding was done according to the program two times by giving concentrated food at the period of cultivation Physic -o -chemical factors were measured. biometery was done monthly at each pen and other fishes (unwanted) were observed at the same time. results indicate that in the 1st and 2nd treatments average survival rate was 52.3 and 41 percent respectively with average weight of 410±64.98 grams and 390±52.8 and 28.3±1.79 cm and 27.66±1.57in length. SPSS used to analysethe data such as average length and weight of fish in the treatments and in different months with ANOVA method (p≤ 0.05) . results show that there is no significant difference between treatments. Autopsy observation also showed that fishes (female and male) are mature and histological studies showed that most of observed eggs are entirely mature with 800-1200 micron diameter gonad ( male) were mature at the pen in the Gorgan Bay condition .The male and female hormones were evaluated. 17-B- Estradiol and 11-keto testosterone hormones for adult fish (female and male) parents respectively are similar in dense with those adult fish before injection to use at the artificial breeding. Maturation were verified by autopsy, histology and hormone studies