Mangosteen Peel Extract vs Tetracycline Gel in Treatment of Periodontal Abscess in Type-2 Diabetes – A Randomized Clinical Trial

Herbal products are gaining popularity due to their diverse biological action and safety. Mangosteen peel extract has antibacterial and anti-inflammatory properties and can be used to treat periodontal diseases. Objective: To compare the efficacy of mangosteen peel extract and tetracycline gel as an adjunct to non-surgical management of periodontal abscess in type-II diabetes patients. Methods: This was a double blinded, randomized clinical trial included 20 Patients with Type-II diabetes. Both test and control groups received NSPT followed by adjunctive local application of mangosteen peel extract and tetracycline gel. Clinical parameters i.e., Probing depth (PPD), Clinical attachment level (CAL), Bleeding Index (BI) and Landry’s healing index (HI) were evaluated at base line and 1 month. Results: In intra and intergroup analysis, both the test and control groups had a better reduction in PPD, BI and CAL with a statistical significance. However, there was no statistical significance between the groups in healing index and showed no change in patient perception in both the groups. Conclusion: 4% mangosteen gel has significantly reduced the BI and PPD with increased CAL and acceptable subjective perception with no recurrence of periodontal abscess over the traditionally used tetracycline gel

Pelatihan Penggunaan Google Classroom dan Google Meet bagi Tenaga Pendidik SMP di Kabupaten Sumba Timur

The implementation of this Community Service activity is motivated by the problems experienced by partners at SMP Kristen Payeti. The teachers in that school have not been able to take advantage of online learning applications such as Google Classroom and Google Meet. Therefore, to overcome the partner's problems, training was carried out by the PkM Team of Program Studi Pendidikan Matematika Universitas Kristen Wira Wacana Sumba, which aims to educate the teachers so that they can increase their knowledge and skills related to the use of the two applications. The training activities were carried out using lectures, demonstrations, and simulations using Google Classroom and Google Meet. While the stages of implementation include the preparation of training modules, preparation of training rooms, and implementation of training. The results of this service activity indicate that there is an increase in the knowledge and skills of teachers as trainees in using the two applications. Thus it can be concluded that the purpose of this service activity has been achieved. The follow-up carried out was to monitor the use of these two applications by teachers in the implementation of online learning

Pelatihan Penggunaan Google Meet dan Google Classroom bagi Dosen Tidak Tetap Universitas Kristen Wira Wacana Sumba

Universitas Kristen Wira Wacana Sumba is one of the universities that organizes online learning. This happened as a result of the COVID-19 pandemic. This situation requires all lecturers to be able to conduct online learning by utilizing the available facilities, namely Google Classroom and Google Meet, both permanent and adjunct lecturers. Permanent lecturers have used the application since the beginning of the covid-19 pandemic, while adjunct lecturers who held lessons this semester have never used the Google Classroom and Google Meet applications. If this is allowed, then learning will not be held properly. Therefore, this training is carried out in several stages, namely analyzing the needs of non-permanent lecturers, implementing activities, and following up. This training makes the online learning by adjunct lecturers can be carried out properly. Based on the results of the follow-up, the participants proposed further training on the use of Google Classroom, especially in making assignment assessment rubrics and quizzes

Mosquitoes Put the Brake on Arbovirus Evolution: Experimental Evolution Reveals Slower Mutation Accumulation in Mosquito Than Vertebrate Cells

Like other arthropod-borne viruses (arboviruses), mosquito-borne dengue virus (DENV) is maintained in an alternating cycle of replication in arthropod and vertebrate hosts. The trade-off hypothesis suggests that this alternation constrains DENV evolution because a fitness increase in one host usually diminishes fitness in the other. Moreover, the hypothesis predicts that releasing DENV from host alternation should facilitate adaptation. To test this prediction, DENV was serially passaged in either a single human cell line (Huh-7), a single mosquito cell line (C6/36), or in alternating passages between Huh-7 and C6/36 cells. After 10 passages, consensus mutations were identified and fitness was assayed by evaluating replication kinetics in both cell types as well as in a novel cell type (Vero) that was not utilized in any of the passage series. Viruses allowed to specialize in single host cell types exhibited fitness gains in the cell type in which they were passaged, but fitness losses in the bypassed cell type, and most alternating passages, exhibited fitness gains in both cell types. Interestingly, fitness gains were observed in the alternately passaged, cloned viruses, an observation that may be attributed to the acquisition of both host cell–specific and amphi-cell-specific adaptations or to recovery from the fitness losses due to the genetic bottleneck of biological cloning. Amino acid changes common to both passage series suggested convergent evolution to replication in cell culture via positive selection. However, intriguingly, mutations accumulated more rapidly in viruses passed in Huh-7 cells than in those passed in C6/36 cells or in alternation. These results support the hypothesis that releasing DENV from host alternation facilitates adaptation, but there is limited support for the hypothesis that such alternation necessitates a fitness trade-off. Moreover, these findings suggest that patterns of genetic evolution may differ between viruses replicating in mammalian and mosquito cells

Evaluation of endoscopic secondary prophylaxis in children and adolescents with esophageal varices

ABSTRACT BACKGROUND - Bleeding of esophageal varices is the main cause of morbidity and mortality in children and adults with portal hypertension and there are few studies involving secondary prophylaxis in children and adolescents. OBJECTIVE - To evaluate the efficacy of endoscopic secondary prophylaxis in prevention of upper gastrointestinal bleeding in children and adolescents with esophageal varices. METHODS - This is a prospective analysis of 85 patients less than 18 years of age with or without cirrhosis, with portal hypertension. Participants underwent endoscopic secondary prophylaxis with sclerotherapy or band ligation. Eradication of varices, incidence of rebleeding, number of endoscopic sessions required for eradication, incidence of developing gastric fundus varices and portal hypertensive gastropathy were evaluated. RESULTS - Band ligation was performed in 34 (40%) patients and sclerotherapy in 51 (60%) patients. Esophageal varices were eradicated in 81.2%, after a median of four endoscopic sessions. Varices relapsed in 38 (55.1%) patients. Thirty-six (42.3%) patients experienced rebleeding, and it was more prevalent in the group that received sclerotherapy. Gastric varices and portal hypertensive gastropathy developed in 38.7% and 57.9% of patients, respectively. Patients undergoing band ligation showed lower rebleeding rates (26.5% vs 52.9%) and fewer sessions required for eradication of esophageal varices (3.5 vs 5). CONCLUSION - Secondary prophylaxis was effective in eradicating esophageal varices and controlling new upper gastrointestinal bleeding episodes due to the rupture of esophageal varices. Band ligation seems that resulted in lower rebleeding rates and fewer sessions required to eradicate varices than did sclerotherapy

Tips praktis bagi wanita hamil

vi, 164 hl

Title not specified

Owambo religious song accompanied by drum and clappin

EFEKTIVITAS AIR REBUSAN DAUN SIRIH HIJAU TERHADAP PERUBAHAN KARAKTERISTIK KEPUTIHAN PADA WANITA USIA SUBUR

Salah satu masalah dalam kesehatan reproduksi yang dialami wanita yaitu keputihan. Terdapat 60 wanita usia subur di dukuh Krajan Desa Padas yang mengalami keputihan dengan barbagai karakteristik dari jumlah cairan, warna, tekstur, bau dan keluhan berbeda yang disebabkan kurangnya menjaga kebersihan daerah kewanitaan serta pengetahuan cara mengatasi keputihan.Penelitian ini bertujuan untuk mengetahui efektivitas air rebusan daun sirih hijau terhadap perubahan karakteristik keputihan pada wanita usia subur.Penelitian ini menggunakan jenis kuantitatif dengan metode quasy experimen dan pendekatan one grup pretsest-posttest design. Subyek dalam penelitian ini adalah wanita usia subur dengan populasi sebanyak 152 orang dan sampel pada penelitian ini menggunakan teknik purposive sampling dengan jumlah 60 responden dimana 30 orang kelompok daun sirih hijau dan 30 orang kelompok daun sirih merah dengan cara membagikan kuesioner pretest dan posttest.Hasil penelitian menunjukkan dari uji statistik mann whitney didapatkan hasil Z skor -3,639 yang berarti terdapat peruubahan karakteristik keputihan sebanyak 3 kali setelah diberikan intervensi air rebusan daun sirih hijau dan nilai pvalue 0.000 ( pvalue

Superior sagittal sinus thrombosis and Budd-Chiari syndrome due to paroxysmal nocturnal hemoglobinuria managed with transjugular intrahepatic portosystemic shunt: a case report

Background: Paroxysmal nocturnal hemoglobinuria (PNH), caused by somatic mutation of hematopoietic cells, is associated with complement-mediated hemolysis and a hypercoagulable state. Thrombotic complications in this disease are associated with reduced survival. We report a patient with PNH complicated by intracranial venous thrombosis and Budd-Chiari syndrome, who was managed with transjugular intrahepatic portosystemic shunt. Case Presentation: A 26-year-old man presented with thrombosis of the superior sagittal and right sigmoid sinuses. Initial investigations did not reveal any underlying cause. Nine months later, he developed hepatic venous thrombosis. At this time, Ham test was positive. Flow cytometry confirmed the diagnosis of PNH. The patient was treated with transjugular intrahepatic portosystemic shunt; one episode of stent blockage one month later was managed successfully with balloon dilatation and restenting. Conclusion: PNH should be considered in patients with unexplained venous thrombosis. Thrombosis in these patients needs to be managed with prolonged anticoagulation. For Budd-Chiari syndrome in patients with underlying PNH, transjugular intrahepatic portosystemic shunt may be a good option but caution is needed to prevent stent occlusion