Static quarks with improved statistical precision

We present a numerical study for different discretisations of the static action, concerning cut-off effects and the growth of statistical errors with Euclidean time. An error reduction by an order of magnitude can be obtained with respect to the Eichten-Hill action, for time separations beyond 1.3 fm, keeping discretization errors small. The best actions lead to a big improvement on the precision of the quark mass Mb and F_Bs in the static approximation.Comment: 3 pages, 4 figures, Lattice2003(heavy

Towards a precision computation of f_Bs in quenched QCD

We present a computation of the decay constant f_Bs in quenched QCD. Our strategy is to combine new precise data from the static approximation with an interpolation of the decay constant around the charm quark mass region. This computation is the first step in demonstrating the feasability of a strategy for f_B in full QCD. The continuum limits in the static theory and at finite mass are taken separately and will be further improved.Comment: Lattice2003(heavy), 3 pages, 2 figure

Can electron distribution functions be derived through the Sunyaev-Zel'dovich effect?

Measurements of the Sunyaev-Zel'dovich (hereafter SZ) effect distortion of the cosmic microwave background provide methods to derive the gas pressure and temperature of galaxy clusters. Here we study the ability of SZ effect observations to derive the electron distribution function (DF) in massive galaxy clusters. Our calculations of the SZ effect include relativistic corrections considered within the framework of the Wright formalism and use a decomposition technique of electron DFs into Fourier series. Using multi-frequency measurements of the SZ effect, we find the solution of a linear system of equations that is used to derive the Fourier coefficients; we further analyze different frequency samples to decrease uncertainties in Fourier coefficient estimations. We propose a method to derive DFs of electrons using SZ multi-frequency observations of massive galaxy clusters. We found that the best frequency sample to derive an electron DF includes high frequencies $\nu$=375, 600, 700, 857 GHz. We show that it is possible to distinguish a Juttner DF from a Maxwell-Bolzman DF as well as from a Juttner DF with the second electron population by means of SZ observations for the best frequency sample if the precision of SZ intensity measurements is less than 0.1%. We demonstrate by means of 3D hydrodynamic numerical simulations of a hot merging galaxy cluster that the morphologies of SZ intensity maps are different for frequencies $\nu$=375, 600, 700, 857 GHz. We stress that measurements of SZ intensities at these frequencies are a promising tool for studying electron distribution functions in galaxy clusters.Comment: 11 pages, 12 figures, published in Astronomy and Astrophysic

Stringing Spins and Spinning Strings

We apply recently developed integrable spin chain and dilatation operator techniques in order to compute the planar one-loop anomalous dimensions for certain operators containing a large number of scalar fields in N =4 Super Yang-Mills. The first set of operators, belonging to the SO(6) representations [J,L-2J,J], interpolate smoothly between the BMN case of two impurities (J=2) and the extreme case where the number of impurities equals half the total number of fields (J=L/2). The result for this particular [J,0,J] operator is smaller than the anomalous dimension derived by Frolov and Tseytlin [hep-th/0304255] for a semiclassical string configuration which is the dual of a gauge invariant operator in the same representation. We then identify a second set of operators which also belong to [J,L-2J,J] representations, but which do not have a BMN limit. In this case the anomalous dimension of the [J,0,J] operator does match the Frolov-Tseytlin prediction. We also show that the fluctuation spectra for this [J,0,J] operator is consistent with the string prediction.Comment: 27 pages, 4 figures, LaTex; v2 reference added, typos fixe

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

In this report, we describe the development of a modified adeno-associated virus (AAV) capsid and promoter for transduction of retinal ON-bipolar cells. The bipolar cells, which are post-synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. In particular, a therapeutic strategy under investigation for advanced forms of blindness involves using optogenetic molecules to render ON-bipolar cells light-sensitive. Currently, delivery of adequate levels of gene expression is a limiting step for this approach. The synthetic AAV capsid and promoter described here achieves high level of optogenetic transgene expression in ON-bipolar cells. This evokes high-frequency (∼100 Hz) spiking responses in ganglion cells of previously blind, rd1, mice. Our vector is a promising vehicle for further development toward potential clinical use

A pilot randomised controlled trial using prophylactic dressings to minimise sacral pressure injuries in high risk hospitalised patients

This pilot randomised controlled trial examined the effect of prophylactic dressings to minimise sacral pressure injuries in high-risk hospitalised patients and assessed feasibility criteria to inform a larger study. Eighty patients were recruited at admission points (the Emergency Department and Surgical Care Unit) or directly from participating wards in the general medical surgical setting following assessment of high risk for sacral pressure injury. Participants were randomised into either the routine care or routine care and silicone foam border dressing group. Outcome assessment comprised digital photographs of each participant’s sacrum every 72 hours for evaluation by a blind-to-intervention assessor. Sixty-seven participants had at least one sacral photograph taken and assessed by a blind-to-intervention assessor. Three participants were assessed as having a Stage I pressure injury. While the use of photography was effective, feasibility criteria identified challenges related to bias, blinding, weight assessment, preparation of nursing staff and sample size estimation

The role of the VEGF-C/VEGFR-3 axis in cancer progression

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression