Unidirectional Lasing Emerging from Frozen Light in Non-Reciprocal Cavities

We introduce a class of unidirectional lasing modes associated with the frozen mode regime of non-reciprocal slow-wave structures. Such asymmetric modes can only exist in cavities with broken time-reversal and space inversion symmetries. Their lasing frequency coincides with a spectral stationary inflection point of the underlying passive structure and is virtually independent of its size. These unidirectional lasers can be indispensable components of photonic integrated circuitry.Comment: 5 pages, 3 figure

Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs.

BackgroundRapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN.Hypothesis/objectivesDogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN.AnimalsForty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN.MethodsRetrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed.ResultsRetrievers and retriever mixes were overrepresented in seroreactive dogs (P < .001). Seroreactive dogs were more likely to have thrombocytopenia (P < .001), azotemia (P = .002), hyperphosphatemia (P < .001), anemia (P < .001), and neutrophilia (P = .003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤ .002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P = .17).Conclusions and clinical importanceC6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment

Twelve tips for teaching brief motivational interviewing to medical students

Background: Shifting from paternalistic to patient-centred doctor-patient relationships has seen a growing number of medical programs incorporate brief motivational interviewing training in their curriculum. Some medical educators, however, are unsure of precisely what, when, and how to incorporate such training. Aims: This article provides educators with 12 tips for teaching brief motivational interviewing to medical students, premised on evidence-based pedagogy. Methods: Tips were drawn from the literature and authors’ own experiences. Results: The 12 tips are: (1) Set clear learning objectives, (2) Select experienced educators, (3) Provide theoretical perspectives, (4) Share the evidence base, (5) Outline the “spirit”, principles, and sequence, (6) Show students what it looks like, (7) Give students a scaffold to follow, (8) Provide opportunities for skill practice, (9) Involve clinical students in teaching, (10) Use varied formative and summative assessments, (11) Integrate and maintain, and (12) Reflect and evaluate. Conclusions: We describe what to include and why, and outline when and how to teach the essential components of brief motivational interviewing knowledge and skills in a medical curriculum

Ion-beam modification of fullerene

The response of thin films of fullerene (C60) to energetic ion impact is investigated. The diagnostics employed include Fourier-transform infrared and Raman spectroscopies, cross-sectional transmission electron microscopy, and atomic force microscopy. By combining the information obtained from these diagnostics with that from the dependence of the conductivity on ion dose, it is concluded that each C60 molecule completely disintegrates when hit by an energetic ion. The cross section for the destruction is about 6×10-13 cm2 for irradiation with 620-keV Xe ions. The disintegration occurs when C atoms are knocked out of the molecule either directly by the impinging ion or by an energetic knock-on C atom within the damage cascade. This process is quite different from the Coulomb-explosion mechanism previously proposed in the literature. For very low ion doses

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression.

Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli. Human genetic data suggest that a diminished HO-1 expression may predispose one to abdominal aortic aneurysm (AAA) development. In addition, heme is known to strongly induce HO-1 expression. Utilizing the porcine pancreatic elastase (PPE) model of AAA induction in HO-1 heterozygous (HO-1+/-, HO-1 Het) mice, we found that a deficiency in HO-1 leads to augmented AAA development. Peritoneal macrophages from HO-1+/- mice showed increased gene expression of pro-inflammatory cytokines, including MCP-1, TNF-alpha, IL-1-beta, and IL-6, but decreased expression of anti-inflammatory cytokines IL-10 and TGF-beta. Furthermore, treatment with heme returned AAA progression in HO-1 Het mice to a wild-type profile. Using a second murine AAA model (Ang II-ApoE-/-), we showed that low doses of the HMG-CoA reductase inhibitor rosuvastatin can induce HO-1 expression in aortic tissue and suppress AAA progression in the absence of lipid lowering. Our results support those studies that suggest that pleiotropic statin effects might be beneficial in AAA, possibly through the upregulation of HO-1. Specific targeted therapies designed to induce HO-1 could become an adjunctive therapeutic strategy for the prevention of AAA disease

Dephasing and Measurement Efficiency via a Quantum Dot Detector

We study charge detection and controlled dephasing of a mesoscopic system via a quantum dot detector (QDD), where the mesoscopic system and the QDD are capacitively coupled. The QDD is considered to have coherent resonant tunnelling via a single level. It is found that the dephasing rate is proportional to the square of the conductance of the QDD for the Breit-Wigner model, showing that the dephasing is completely different from the shot noise of the detector. The measurement rate, on the other hand, shows a dip near the resonance. Our findings are peculiar especially for a symmetric detector in the following aspect: The dephasing rate is maximum at resonance of the QDD where the detector conductance is insensitive to the charge state of the mesoscopic system. As a result, the efficiency of the detector shows a dip and vanishes at resonance, in contrast to the single-channel symmetric non-resonant detector that has always a maximum efficiency. We find that this difference originates from a very general property of the scattering matrix: The abrupt phase change exists in the scattering amplitudes in the presence of the symmetry, which is insensitive to the detector current but {\em stores} the information of the quantum state of the mesoscopic system.Comment: 7 pages, 3 figure

Low-temperature tapered-fiber probing of diamond NV ensembles coupled to GaP microcavities

In this work we present a platform for testing the device performance of a cavity-emitter system, using an ensemble of emitters and a tapered optical fiber. This method provides high-contrast spectra of the cavity modes, selective detection of emitters coupled to the cavity, and an estimate of the device performance in the single- emitter case. Using nitrogen-vacancy (NV) centers in diamond and a GaP optical microcavity, we are able to tune the cavity onto the NV resonance at 10 K, couple the cavity-coupled emission to a tapered fiber, and measure the fiber-coupled NV spontaneous emission decay. Theoretically we show that the fiber-coupled average Purcell factor is 2-3 times greater than that of free-space collection; although due to ensemble averaging it is still a factor of 3 less than the Purcell factor of a single, ideally placed center.Comment: 15 pages, 6 figure

A robust, scanning quantum system for nanoscale sensing and imaging

Controllable atomic-scale quantum systems hold great potential as sensitive tools for nanoscale imaging and metrology. Possible applications range from nanoscale electric and magnetic field sensing to single photon microscopy, quantum information processing, and bioimaging. At the heart of such schemes is the ability to scan and accurately position a robust sensor within a few nanometers of a sample of interest, while preserving the sensor's quantum coherence and readout fidelity. These combined requirements remain a challenge for all existing approaches that rely on direct grafting of individual solid state quantum systems or single molecules onto scanning-probe tips. Here, we demonstrate the fabrication and room temperature operation of a robust and isolated atomic-scale quantum sensor for scanning probe microscopy. Specifically, we employ a high-purity, single-crystalline diamond nanopillar probe containing a single Nitrogen-Vacancy (NV) color center. We illustrate the versatility and performance of our scanning NV sensor by conducting quantitative nanoscale magnetic field imaging and near-field single-photon fluorescence quenching microscopy. In both cases, we obtain imaging resolution in the range of 20 nm and sensitivity unprecedented in scanning quantum probe microscopy

Fano Effect in a Few-Electron Quantum Dot

We have studied the Fano effect in a few-electron quantum dot side-coupled to a quantum wire. The conductance of the wire, which shows an ordinal staircase-like quantization without the dot, is modified through the interference (the Fano effect) and the charging effects. These effects are utilized to verify the exhaustion of electrons in the dot. The "addition energy spectrum" of the dot shows a shell structure, indicating that the electron confinement potential is fairly circular. A rapid sign inversion of the Fano parameter on the first conductance plateau with the change of the wire gate voltage has been observed, and explained by introducing a finite width of dot-wire coupling.Comment: 11 pages, 7 figure

The preparation of zirconium powder

The preparation of zirconium powder by several different methods is fully described and evaluated. Most of the methods described are of a rather classical nature and these methods are discussed as taken from their original sources with suggestions for possible streamlining. Flow sheets are provided. The first series of steps to produce zirconium powder is almost invariably the production of pure zirconium tetrachloride or pure zirconium oxide from the tetrachloride. The processes described include the sodium reduction of zirconium tetrachloride, sodium reduction of the double alkali fluorides, the calcium reduction of zirconium oxide, hydrogen embrittlement and comminution of reduction products. The hydride method as utilized for zirconium sponge is a good process to make zirconium powder. This method which is described in detail can be nicely used to produce zirconium hydride or zirconium powder from any pure reduction product. While arc-melted or massive zirconium can be hydrided, material with larger surface area, e.g. sponge, is more favorable. The calcium reduction of zirconium oxide also has potential method to produce a good zirconium powder. It is concluded that suitable zirconium powder will be available as an increased demand arises. Methods tor safe handling of zirconium powder are briefly described --Abstract, page 2