La medida en que habito

31 p. Recurso Electr?nicoEl proyecto experimenta distintas etapas durante su desarrollo, van desde la exploraci?n-observaci?n, recolecci?n-selecci?n, y la construcci?n-interacci?n; mediante dichas acciones se descubre el factor clave y es la relaci?n con el espacio, una necesidad inconsciente en el cuidado y transformaci?n del mismo; habilidad que seg?n Careri solo les pertenece y es condici?n propia de los ?sedentarios?, ya que para ?l mismo autor, los n?madas carecen de tal capacidad por su condici?n de transitoriedad en los espacios. En su primera etapa denominada Exploraci?n-Observaci?n, el espacio escogido para interactuar fue la universidad, pues consideraba que era mi entorno inmediato, sin embargo, dichos espacios resultaron tan grandes que no me permitieron reconocer mi identidad dentro de ellos, por tal raz?n, el lugar objeto de intervenci?n se redujo a mi casa, mi lugar m?s ?ntimo objeto de transformaci?n constante. Igualmente, fue necesario indagar, investigar, encontrar una base te?rica que permitiera dar base, al menos conceptual y comprender la raz?n que motiv? intervenir experimentalmente mi espacio; grandes autores aparecieron Manel Margalef, Francesco Careri, Michel De Certau, Jean Baudrillard, entre otros, todos ofrecieron conceptos, algunos adopte y otros refute, principalmente el nomadismo de Careri, t?rmino que permite la construcci?n de este proyecto. Finalmente, en su tercera etapa, denominada construcci?n-interacci?n apropi? los espacios abandonados y a trav?s de elementos elaborados con base en papel desechado, intervine mediante escenas y/o im?genes propias del lugar a trav?s de grafismos o dibujo figurativo, en dicho momento alimente mi trabajo con referentes claves, Leon Ferrari, Slikanchu, quienes con sus grafismo y escritura deformada me permit?a hacer los dibujos para los lugares que interven?a.The project undergoes various stages during its development, ranging from explorationobservation, collection-selection, and construction-interaction; through these actions the key factor is discovered and the relationship with space, an unconscious need care and transformation thereof; Careri skill as theirs and only own condition of "sedentary" as for himself author, nomads lack such capacity for their condition transience in the spaces. In its first stage called Scan-Observation, the space chosen to interact was the university, considering that was my immediate environment, however, those spaces were so great that did not allow me to recognize my identity within them, for that reason, place for intervention fell to my house, my most intimate place under constant transformation. Similarly, it was necessary to investigate, investigate, find a theoretical basis that would give base, at least conceptually and understand the reason behind intervene experimentally my space; Manel Margalef great authors appeared, Francesco Careri, Michel De Certeau, Jean Baudrillard, among others, all offered concepts, some adopted and others refute mainly nomadism of Careri, a term that allows the construction of this project. Finally, in its third stage, called construction-interaction appropriated abandoned and through elements developed based on wastepaper spaces, interved by scenes and / or own images of the site through graphics or figurative drawing, at that time feed my job with key referents, Leon Ferrari, Slikanchu, who with their distorted graphics and writing allowed me to make drawings for places that intervened. Keywords: space, drawing, dwelling, nomadic, anarchitects

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model

The corticotropin-releasing factor (CRF)-producing neurons of the amygdala have been implicated in behavioral and physiological responses associated with fear, anxiety, stress, food intake and reward. To overcome the difficulties in identifying CRF neurons within the amygdala, a novel transgenic mouse line, in which the humanized recombinant Renilla reniformis green fluorescent protein (hrGFP) is under the control of the CRF promoter (CRF-hrGFP mice), was developed. First, the CRF-hrGFP mouse model was validated and the localization of CRF neurons within the amygdala was systematically mapped. Amygdalar hrGFP-expressing neurons were located primarily in the interstitial nucleus of the posterior limb of the anterior commissure, but also present in the central amygdala. Secondly, the marker of neuronal activation c-Fos was used to explore the response of amygdalar CRF neurons in CRF-hrGFP mice under different experimental paradigms. C-Fos induction was observed in CRF neurons of CRF-hrGFP mice exposed to an acute social defeat stress event, a fasting/refeeding paradigm or lipopolysaccharide (LPS) administration. In contrast, no c-Fos induction was detected in CRF neurons of CRF-hrGFP mice exposed to restraint stress, forced swimming test, 48-h fasting, acute high-fat diet (HFD) consumption, intermittent HFD consumption, ad libitum HFD consumption, HFD withdrawal, conditioned HFD aversion, ghrelin administration or melanocortin 4 receptor agonist administration. Thus, this study fully characterizes the distribution of amygdala CRF neurons in mice and suggests that they are involved in some, but not all, stress or food intake-related behaviors recruiting the amygdala

Pencegahan Demam Berdarah Dengue Pasca Musim Hujan di Dusun Air Besar Desa Batu Merah Kota Ambon

Demam berdarah adalah virus menular yang ditularkan oleh nyamuk, khususnya Aedes aegypti dan Aedes albopictus, yang mempengaruhi kesehatan masyarakat secara global. Dengan empat serotipe berbeda dari virus penyebab penyakit ini, Indonesia telah melihat angka kematian yang tinggi selama empat tahun terakhir, dengan 705 kematian pada tahun 2021, 1.236 kasus pada tahun 2022, 894 kasus pada tahun 2023, dan 316 kematian dilaporkan hingga 18 Maret 2024. Metode yang digunakan dalam pelaksanaan kegiatan pengabdian kepada masyarakat ini adalah Focus Group Discussion (FGD), penyuluhan, dan pembagian poster. Sasaran pada kegiatan ini adalah masyarakat yang memiliki anak usia 5-12 tahun berjumlah 50 orang. Hasil menunjukkan bahwa apabila penyebaran penyakit DBD tidak dicegah maka dampak yang ditimbulkan adalah dampak kesehatan seperti terjadi komplikasi hingga kematian, dampak ekonomi seperti bertambahnya pengeluaran untuk rawat inap dan pembelian obat-obatan, dampak sosial seperti timbulnya kepanikan dan stigma di masyarakat serta kehilangan anggota keluarga. Pencegahan penyebaran penyakit DBD dapat dilakukan dengan cara 3M Plus antara lain menguras tempat penampungan air, menutup tempat penampungan air, dan mengubur benda-benda yang dapat menapung air, serta Plus yakni tidur menggunakan kelambu, menanam tanaman yang dapat mengusir nyamuk dan memasang kasa pada lubang udara. Dengan adanya kegiatan ini diharapkan wawasan masyarakat bertambah dalam mencegah penyakit yang disebabkan oleh vektor

ESTEREOTIPOS DE ROLES DE GÉNERO Y AGRESIVIDAD EN TRABAJADORES DE LA MUNICIPALIDAD DE ALTO LARAN - 2022

El estudio buscó como objetivo fue establecer como los estereotipos de roles de género se relacionan con la agresividad en los colaboradores de la Municipalidad de Alto Laran en 2022. Se seleccionó como no experimental transversal al diseño, siguiéndose los lineamientos de un enfoque cuantitativo bajo un alcance correlacional. Se partió de una muestra de 108 colaboradores de edades entre 18 a 70 años. Se utilizaron los instrumentos del Inventario de Agresividad de Buss & Perry adaptado por Matalanares (2012) y Estereotipos de Roles de Género de Bem adaptado por Razul (1991), ambos en versión peruana. Los resultados revelaron que el 53.7% de los colaboradores mostraron una mayor predominancia en la dimensión de distracción o filtros, y el 47.2% presentó niveles medio significativos de agresividad. Demostrándose que, no existe relación entre ambas variables

Additive Manufacturing: Investment Casting Prototype Pantera Using 3D Printed PMMA Pattern

This project explores the investment casting method by varying the pattern-making approach, utilizing 3D printing of PMMA patterns instead of traditional wax or injected polymer patterns to reduce pattern-making costs. The process involves printing the PMMA pattern from a CAD design and manually applying a thin wax coating to enhance the surface finish. The ceramic shell is created using a fused silica and colloidal silica slurry, with a fine silica sand coating until the shell reaches an approximate thickness of 5/16 inches. A specialized robotic system is used for the ceramic coating process, making it faster and easier than traditional methods. The pattern is then melted using a pre-heating furnace, leaving the ceramic shell mold ready for molten metal pouring. This practice demonstrates the benefits of using 3D-printed patterns, such as improved surface finishes and the ability to create more complex patterns through 3D modeling, while also recognizing the time savings achieved through the use of robotic and automated machinery

Unpacking overuse of androgen deprivation therapy for prostate cancer to inform de-implementation strategies

Peer reviewe

Efecto del tratamiento con ácido zoledrónico e hidroxocobalamina sobre la microarquitectura ósea en ratones con periodontitis y osteoporosis inducida: Estudio preclínico

Objetivo. Evaluar el efecto del tratamiento con ácido zoledrónico e hidroxocobalamina sobre la microarquitectura ósea alveolar en ratones con periodontitis y osteoporosis inducidas. Métodos. Diseño experimental en fase preclínica. Se incluyeron 16 ratones hembras a quienes se les indujo osteoporosis mediante la ovariectomía total y también se indujo la periodontitis por inflamación por ligadura de seda negra 5/0 en el segundo molar maxilar, todos los protocolos fueron sometidos durante anestesia general. Los ratones se distribuyeron en 4 grupos: control, tratamiento con ácido zoledrónico, tratamiento con hidroxocobalamina y tratamiento combinado. A las 16 semanas, se realizó la autanasia, se realizó la disección para la evaluación mediante microtomografía; determinando la densidad mineral ósea (BMD), el volumen de hueso (BV/TV), espesor trabecular (Tb.Th), número de trabéculas (Tb.N), separación trabecular (Tb.Sp); se realizó el análisis descriptivo y bivariado mediante ANOVA de 1 vía considerando un 95% de nivel de confianza. Resultados. El grupo que recibió tratamiento combinado de ácido zoledrónico e hidroxocobalamina presentó mayor densidad mineral ósea (DMO), mayor volumen óseo (BV/TV) y menor separación trabecular (Tb.Sp) en comparación con el grupo de control (p<0,05). Conclusiones. El tratamiento combinado de ácido zoledrónico e hidroxocobalamina mejora las características microarquitectónicas óseas en ratones con osteoporosis y periodontitis inducidas.Objective. Evaluate the effect of zoledronic acid and hydroxocobalamin treatment on alveolar bone microarchitecture in mice with induced periodontitis and osteoporosis. Methods. Experimental design in preclinical phase. Sixteen female mice were included in which osteoporosis was induced by total ovariectomy and periodontitis was also induced by inflammation by 5/0 black silk ligation of the maxillary second molar, all protocols were performed under general anesthesia. The mice were distributed into 4 groups: control, treatment with zoledronic acid, treatment with hydroxocobalamin and combined treatment. At 16 weeks, euthanasia was performed, dissection was performed for evaluation by microtomography; determining bone mineral density (BMD), bone volume (BV/TV), trabecular thickness (Tb.Th), number of trabeculae (Tb.N), trabecular separation (Tb.Sp); descriptive and bivariate analysis was performed using 1-way ANOVA with a 95% confidence level. Results. The group that received combined treatment of zoledronic acid and hydroxocobalamin presented higher bone mineral density (BMD), higher bone volume (BV/TV) and lower trabecular separation (Tb.Sp) compared to the control group (p<0.05). Conclusions. Combined treatment with zoledronic acid and hydroxocobalamin improves bone microarchitectural features in mice with induced osteoporosis and periodontitis

Surveillance of Sentinel Node-Positive Melanoma Patients with Reasons for Exclusion from MSLT-II:Multi-Institutional Propensity Score Matched Analysis

BACKGROUND: In sentinel lymph node (SLN)-positive melanoma, two randomized trials demonstrated equivalent melanoma-specific survival with nodal surveillance vs completion lymph node dissection (CLND). Patients with microsatellites, extranodal extension (ENE) in the SLN, or >3 positive SLNs constitute a high-risk group largely excluded from the randomized trials, for whom appropriate management remains unknown. STUDY DESIGN: SLN-positive patients with any of the three high-risk features were identified from an international cohort. CLND patients were matched 1:1 with surveillance patients using propensity scores. Risk of any-site recurrence, SLN-basin-only recurrence, and melanoma-specific mortality were compared. RESULTS: Among 1,154 SLN-positive patients, 166 had ENE, microsatellites, and/or >3 positive SLN. At 18.5 months median follow-up, 49% had recurrence (vs 26% in patients without high-risk features, p 3 positive SLN constitute a high-risk group with a 2-fold greater recurrence risk. For those managed with nodal surveillance, SLN-basin recurrences were more frequent, but all-site recurrence and melanoma-specific mortality were comparable to patients treated with CLND. Most recurrences were outside the SLN-basin, supporting use of nodal surveillance for SLN-positive patients with microsatellites, ENE, and/ or >3 positive SLN

Active surveillance of patients who have sentinel node positive melanoma:An international, multi-institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy trial II (MSLT-2)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/168248/1/cncr33483.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/168248/2/cncr33483_am.pd

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Background Inhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome‐wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response. Objective We aimed to identify genetic variants associated with asthma exacerbations in admixed children treated with ICS and to validate previous GWAS findings. Methods A meta‐analysis of two GWAS of asthma exacerbations was performed in 1347 admixed children treated with ICS (Hispanics/Latinos and African Americans), analysing 8.7 million genetic variants. Those with P ≤ 5 × 10−6 were followed up for replication in 1697 asthmatic patients from six European studies. Associations of ICS response described in published GWAS were followed up for replication in the admixed populations. Results A total of 15 independent variants were suggestively associated with asthma exacerbations in admixed populations (P ≤ 5 × 10−6). One of them, located in the intergenic region of APOBEC3B and APOBEC3C, showed evidence of replication in Europeans (rs5995653, P = 7.52 × 10−3) and was also associated with change in lung function after treatment with ICS (P = 4.91 × 10−3). Additionally, the reported association of the L3MBTL4‐ARHGAP28 genomic region was confirmed in admixed populations, although a different variant was identified. Conclusions and clinical relevance This study revealed the novel association of APOBEC3B and APOBEC3C with asthma exacerbations in children treated with ICS and replicated previously identified genomic regions. This contributes to the current knowledge about the multiple genetic markers determining responsiveness to ICS which could lead in the future the clinical identification of those asthma patients who are not able to respond to such treatment