Temperature dependence of the diffuse scattering fine structure in equiatomic CuAu

The temperature dependence of the diffuse scattering fine structure from disordered equiatomic CuAu was studied using {\it in situ} x-ray scattering. In contrast to Cu$_3$Au the diffuse peak splitting in CuAu was found to be relatively insensitive to temperature. Consequently, no evidence for a divergence of the antiphase length-scale at the transition temperature was found. At all temperatures studied the peak splitting is smaller than the value corresponding to the CuAuII modulated phase. An extended Ginzburg-Landau approach is used to explain the temperature dependence of the diffuse peak profiles in the ordering and modulation directions. The estimated mean-field instability point is considerably lower than is the case for Cu$_3$Au.Comment: 4 pages, 5 figure

UJI DYNAMIC BINDING CAPACITY KOLOM MONOLITH POLY (MATE-CO-VBC-CO-EDMA) PADA SAMPEL BIOMOLEKUL BOVINE SERUM ALBUMIN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI

Kolom monolith poly(MATE-co-VBC-co-EDMA) dengan %T 35, dan %C 50 merupakan komposisi total monomer dan komposisi cross linker yang ideal, yaitu mempunyai kestabilan mekanis dan mekanis yang baik, molecular recognitioan sites memadai (ditandai dengan binding capacity 22,208 mg mL−1), serta proporsi flow-trough pores dan mesopores seimbang yaitu 24,24% dan 44,32%. Kolom Monolith %T 35% dan %C 50% mampu memisahkan secara akurat sampel biomolekul oligo(dT12-dT18) dan fragmen DNA dengan resolusi masing-masing 1,4 dan 1,0. Dari aplikasi model sampel oligo(dT12-dT18) dan fragmen DNA , pada pemisahan oligo(dT12-dT18) mekanisme pemisahan adalah penukar ion, sedangkan pada pada DNA termetilasi mekanisme pemisahan adalah interaksi hidrofobik, sehingga monolith poly(MATE-co-VBC-co-EDMA). Memberikan dua mekanisme pemisahan yang berbeda (dual-mode) pada aplikasisampel-sampel DN

Positioning a coarse-calibrated camera with respect to an unknown object by 2D 1/2 visual servoing

International audienceIn this paper we propose a new vision-based robot control approach halfway between the classical position-based and image-based visual servoings. It allows to avoid their respective disadvantages. The homography between some planar feature points extracted from two images (corresponding to the current and desired camera poses) is computed at each iteration. Then, an approximate partial-pose, where the translational term is known only up to a scale factor, is deduced, from which can be designed a closed-loop control law controlling the six camera d.o.f.. Contrarily to the position-based visual servoing, our scheme does not need any geometric 3D model of the object. Furthermore and contrarily to the image-based visual servoing, our approach ensures the convergence of the control law in all the task space

Economic Methods of Managing the Environmental Safety of Cities Abroad: Tax Aspect

The purpose of the study is to analyze and generalize the economic methods used abroad for managing the environmental safety of a city and to assess the possibility of their use in the practice of Russian cities. The relevance of the work is conditioned by the fact that a significant part of large Russian cities and megalopolises are faced with serious problems in the environmental sphere. Abroad, many years of experience have been accumulated in solving similar issues through the use of methods for managing the environmental safety of the city, which is an argument in favor of its study. The article analyzes the practice of OECD countries in applying economic measures to reduce environmental pollution, ensure environmental balance and comfortable living conditions for the city population. Particular attention is paid to the powers of local governments in the environmental sphere and the degree of their financial autonomy; the benefits of environmental taxation in EU countries, including the transition to a low-carbon economy; organization of ecological cooperation on the principles of the circular economy and within the framework of the model of industrial symbiosis for the processing or use of industrial and household waste. In the course of the work, general scientific and special methods were used, including content analysis of literary sources, comparison, grouping, analogy, systemic and structural analysis, logical generalization. The results of the study consist in assessing the possibilities and determining the conditions for introducing the best foreign practices in environmental safety management in Russian cities; they can be useful to specialists dealing with both the problems of forming management decisions to stabilize the environmental situation in the city, greening the tax system at the local level, and ensuring the rational use of resources in a mobilization economy through cooperative relations in the processing of industrial and household waste through recycling

Sex-specific genetic effects influence variation in body composition

Aims/hypothesis: Despite well-known sex differences in body composition it is not known whether sex-specific genetic or environmental effects contribute to these differences. Methods: We assessed body composition in 2,506 individuals, from a young Dutch genetic isolate participating in the Erasmus Rucphen Family study, by dual-energy X-ray absorptiometry and anthropometry. We used variance decomposition procedures to partition variation of body composition into genetic and environmental components common to both sexes and to men and women separately and calculated the correlation between genetic components in men and women. Results: After accounting for age

Changes in the ceIl membrane of Lactobacillus bulgaricus during storage following freeze-drying

The mechanism of inactivation of freeze-dried Lactobacillus bulgaricus during storage in maltodextrin under controlled humidity was investigated. Evidence is presented supporting the hypothesis that membrane damage occurs during storage. A study on the lipid composition of the cells by gas chromatography showed a decrease in the unsaturated and saturated fatty acid content of the cell. Further evidence indicating membrane damage includes a decrease in membrane bound proton-translocating ATPase activity

Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).

In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated through activating point mutations or genomic amplification. We studied ALK genetic alterations in high-risk (HR) patients on the HR-NBL1/SIOPEN trial to determine their frequency, correlation with clinical parameters, and prognostic impact. Diagnostic tumor samples were available from 1,092 HR-NBL1/SIOPEN patients to determine ALK amplification status (n = 330), ALK mutational profile (n = 191), or both (n = 571). Genomic ALK amplification (ALKa) was detected in 4.5% of cases (41 out of 901), all except one with MYCN amplification (MNA). ALKa was associated with a significantly poorer overall survival (OS) (5-year OS: ALKa [n = 41] 28% [95% CI, 15 to 42]; no-ALKa [n = 860] 51% [95% CI, 47 to 54], [P < .001]), particularly in cases with metastatic disease. ALK mutations (ALKm) were detected at a clonal level (> 20% mutated allele fraction) in 10% of cases (76 out of 762) and at a subclonal level (mutated allele fraction 0.1%-20%) in 3.9% of patients (30 out of 762), with a strong correlation between the presence of ALKm and MNA (P < .001). Among 571 cases with known ALKa and ALKm status, a statistically significant difference in OS was observed between cases with ALKa or clonal ALKm versus subclonal ALKm or no ALK alterations (5-year OS: ALKa [n = 19], 26% [95% CI, 10 to 47], clonal ALKm [n = 65] 33% [95% CI, 21 to 44], subclonal ALKm (n = 22) 48% [95% CI, 26 to 67], and no alteration [n = 465], 51% [95% CI, 46 to 55], respectively; P = .001). Importantly, in a multivariate model, involvement of more than one metastatic compartment (hazard ratio [HR], 2.87; P < .001), ALKa (HR, 2.38; P = .004), and clonal ALKm (HR, 1.77; P = .001) were independent predictors of poor outcome. Genetic alterations of ALK (clonal mutations and amplifications) in HR-NB are independent predictors of poorer survival. These data provide a rationale for integration of ALK inhibitors in upfront treatment of HR-NB with ALK alterations

Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach

Background: Although the relationship between serum uric acid (SUA) and adiposity is well established, the direction of the causality is still unclear in the presence of conflicting evidences. We used a bidirectional Mendelian randomization approach to explore the nature and direction of causality between SUA and adiposity in a population-based study of Caucasians aged 35 to 75 years. Methods and Findings: We used, as instrumental variables, rs6855911 within the SUA gene SLC2A9 in one direction, and combinations of SNPs within the adiposity genes FTO, MC4R and TMEM18 in the other direction. Adiposity markers included weight, body mass index, waist circumference and fat mass. We applied a two-stage least squares regression: a regression of SUA/adiposity markers on our instruments in the first stage and a regression of the response of interest on the fitted values from the first stage regression in the second stage. SUA explained by the SLC2A9 instrument was not associated to fat mass (regression coefficient [95 % confidence interval]: 0.05 [20.10, 0.19] for fat mass) contrasting with the ordinary least square estimate (0.37 [0.34, 0.40]). By contrast, fat mass explained by genetic variants of the FTO, MC4R and TMEM18 genes was positively and significantly associated to SUA (0.31 [0.01, 0.62]), similar to the ordinary least square estimate (0.27 [0.25, 0.29]). Results were similar for the other adiposity markers. Conclusions: Using a bidirectional Mendelian randomization approach in adult Caucasians, our findings suggest tha