Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report

Introduction. We report a rare presentation of Castleman's disease in a hepatitis C-positive patient and present a short review of treatments described in other similar case reports and studies. Case Presentation. A 46-year-old male with untreated hepatitis C and a 16-year history of intravenous drug use presented with pleuritic chest pain and bony pain in the knee, hip, and lower back, on a background of unexplained weight loss of 40 kilograms, fevers, night sweats, and repeated infections over the last two years. Examination discovered tender hepatomegaly, a warm right knee effusion, and painless lymphadenopathy. The patient was reactive to Epstein Barr virus and cytomegalovirus; however, HIV and HHV-8 viral testing was negative. Osteomyelitis of vertebrae T8–T11 and septic arthritis of the knee were found on investigation. A lymph node biopsy revealed histology suggestive of plasmacytic Castleman's disease. The patient is to commence rituximab treatment. Conclusion. Castleman's disease continues to present in novel ways, which may lead to difficulties in clinicopathologic diagnosis. A growing body of evidence suggests larger studies are required to determine the best treatment for multicentric Castleman's disease, particularly in patients with a concomitant disease, including hepatitis C

Three-dimensional printing in oral and maxillofacial surgery: Current landscape and future directions

Abstract Three‐dimensional (3D) printing technology continues to develop at a rapid pace, with the potential to revolutionise multiple industries and fields including medicine. Oral and maxillofacial surgeons are particularly well placed to advance and integrate this technology into practice. This review provides a summary of 3D printing and discusses the current and future applications of this technology in oral and maxillofacial surgery, including the production of surgical planning models, training tools, cutting guides and personalised implants. While early research is promising, there still remains a paucity of large‐scale, well‐controlled clinical studies supporting the use of 3D printing technologies for many of these applications. There are also a number of other technical and regulatory challenges which will need to be addressed as this technology is taken up more widely

Return Chasing as a Driver in Individual Retirement Savings Investment Choices: Evidence from Australia

Behavioral finance, Investment choice, Retirement savings,