Maternal serum βhCG level and uterine artery doppler studies as predictors of pregnancy induced hypertension and intra uterine growth restriction: a prospective study

Background: PIH, a pregnancy-specific disorder, is one of the major causes of maternal and perinatal morbidity and mortality worldwide.PIH and fetal growth restriction are important causes of perinatal and maternal morbidity and mortility.Methods: Hundred Indian pregnant women in their second trimester (13-20 weeks) and in their late second trimester (24-28 weeks) investigated for their serum β-hCG level and uterine artery Doppler studies respectively, attending OPD/IPD in Sir T. hospital, Bhavnagar from June 2014 to June 2015.Results: There is no clinical significance between parity and occurrence of PIH (p=0.2) and FGR (p=0.7). Out of 77 patients with their β hCG level ≤2 MoM, 2 patients (2.59%) developed PIH and FGR. And from 12 patients with their β hCG level ≥2 MoM 10 patients (80%) developed PIH and FGR which is highly significant (p<0.001). The study establishes the validity of beta HCG as a predictor of PIH and FGR with the sensitivity of 83.3%, specificity of 97.5%.Conclusions: This study can be concluded by there is a strong association between high maternal serum ß-hCG level, abnormal uterine Doppler studies with predicting adverse outcome of pregnancy like PIH and FGR. There is also a good association between high maternal serum ß-hCG level and rising severity of the disease

Constraining Cosmic-ray Transport with Observations of the Circumgalactic Medium

Recent theoretical studies predict that the circumgalactic medium (CGM) around low-redshift, $\sim L_*$ galaxies could have substantial nonthermal pressure support in the form of cosmic rays. However, these predictions are sensitive to the specific model of cosmic-ray transport employed, which is theoretically and observationally underconstrained. In this work, we propose a novel observational constraint for calculating the lower limit of the radially-averaged, effective cosmic-ray transport rate, $\kappa_{\rm min}^{\rm eff}$. Under a wide range of assumptions (so long as cosmic rays do not lose a significant fraction of their energy in the galactic disk, regardless of whether the cosmic-ray pressure is important or not in the CGM), we demonstrate a well-defined relationship between $\kappa_{\rm min}^{\rm eff}$ and three observable galaxy properties: the total hydrogen column density, the average star formation rate, and the gas circular velocity. We use a suite of FIRE-2 galaxy simulations with a variety of cosmic-ray transport physics to demonstrate that our analytic model of $\kappa_{\rm min}^{\rm eff}$ is a robust lower limit of the true cosmic-ray transport rate. We then apply our new model to calculate $\kappa_{\rm min}^{\rm eff}$ for galaxies in the COS-Halos sample, and confirm this already reveals strong evidence for an effective transport rate which rises rapidly away from the interstellar medium to values $\kappa_{\rm min}^{\rm eff}\gtrsim 10^{30-31}\,{\rm cm}^2\,{\rm s}^{-1}$ (corresponding to anisotropic streaming velocities of $v^{\rm stream}_{\rm eff} \gtrsim 1000\,{\rm km}\,{\rm s}^{-1}$) in the diffuse CGM, at impact parameters larger than $50-100$\,kpc. We discuss how future observations can provide qualitatively new constraints in our understanding of cosmic rays in the CGM and intergalactic medium.Comment: 9 pages, 2 figures, accepted to MNRA

Maternal serum βhCG level and uterine artery doppler studies as predictors of pregnancy induced hypertension and intra uterine growth restriction: a prospective study

Background: PIH, a pregnancy-specific disorder, is one of the major causes of maternal and perinatal morbidity and mortality worldwide.PIH and fetal growth restriction are important causes of perinatal and maternal morbidity and mortility.Methods: Hundred Indian pregnant women in their second trimester (13-20 weeks) and in their late second trimester (24-28 weeks) investigated for their serum β-hCG level and uterine artery Doppler studies respectively, attending OPD/IPD in Sir T. hospital, Bhavnagar from June 2014 to June 2015.Results: There is no clinical significance between parity and occurrence of PIH (p=0.2) and FGR (p=0.7). Out of 77 patients with their β hCG level ≤2 MoM, 2 patients (2.59%) developed PIH and FGR. And from 12 patients with their β hCG level ≥2 MoM 10 patients (80%) developed PIH and FGR which is highly significant (p&lt;0.001). The study establishes the validity of beta HCG as a predictor of PIH and FGR with the sensitivity of 83.3%, specificity of 97.5%.Conclusions: This study can be concluded by there is a strong association between high maternal serum ß-hCG level, abnormal uterine Doppler studies with predicting adverse outcome of pregnancy like PIH and FGR. There is also a good association between high maternal serum ß-hCG level and rising severity of the disease.</jats:p