Towards wafer scale inductive determination of magnetostatic and dynamic parameters of magnetic thin films and multilayers

We investigate an inductive probe head suitable for non-invasive characterization of the magnetostatic and dynamic parameters of magnetic thin films and multilayers on the wafer scale. The probe is based on a planar waveguide with rearward high frequency connectors that can be brought in close contact to the wafer surface. Inductive characterization of the magnetic material is carried out by vector network analyzer ferromagnetic resonance. Analysis of the field dispersion of the resonance allows the determination of key material parameters such as the saturation magnetization MS or the effective damping parameter Meff. Three waveguide designs are tested. The broadband frequency response is characterized and the suitability for inductive determination of MS and Meff is compared. Integration of such probes in a wafer prober could in the future allow wafer scale in-line testing of magnetostatic and dynamic key material parameters of magnetic thin films and multilayers

Electromagnetic Simulation and Design of a Novel Waveguide RF Wien Filter for Electric Dipole Moment Measurements of Protons and Deuterons

The conventional Wien filter is a device with orthogonal static magnetic and electric fields, often used for velocity separation of charged particles. Here we describe the electromagnetic design calculations for a novel waveguide RF Wien filter that will be employed to solely manipulate the spins of protons or deuterons at frequencies of about 0.1 to 2 MHz at the COoler SYnchrotron COSY at J\"ulich. The device will be used in a future experiment that aims at measuring the proton and deuteron electric dipole moments, which are expected to be very small. Their determination, however, would have a huge impact on our understanding of the universe.Comment: 10 pages, 10 figures, 4 table

Antiferromagnetic Ising spin glass competing with BCS pairing interaction in a transverse field

The competition among spin glass (SG), antiferromagnetism (AF) and local pairing superconductivity (PAIR) is studied in a two-sublattice fermionic Ising spin glass model with a local BCS pairing interaction in the presence of an applied magnetic transverse field $\Gamma$. In the present approach, spins in different sublattices interact with a Gaussian random coupling with an antiferromagnetic mean $J_0$ and standard deviation $J$. The problem is formulated in the path integral formalism in which spin operators are represented by bilinear combinations of Grassmann variables. The saddle-point Grand Canonical potential is obtained within the static approximation and the replica symmetric ansatz. The results are analysed in phase diagrams in which the AF and the SG phases can occur for small $g$ ($g$ is the strength of the local superconductor coupling written in units of $J$), while the PAIR phase appears as unique solution for large $g$. However, there is a complex line transition separating the PAIR phase from the others. It is second order at high temperature that ends in a tricritical point. The quantum fluctuations affect deeply the transition lines and the tricritical point due to the presence of $\Gamma$.Comment: 16 pages, 6 figures, accepted Eur. Phys. J.

First Results from MASIV: The Micro-Arcsecond Scintillation-Induced Variability Survey

We are undertaking a large-scale, Micro-Arcsecond Scintillation-Induced Variability (MASIV) survey of the northern sky, Dec > 0 deg, at 4.9 GHz with the VLA. Our objective is to construct a sample of 100 to 150 scintillating extragalactic sources with which to examine both the microarcsecond structure and the parent populations of these sources, and to probe the turbulent interstellar medium responsible for the scintillation. We report on our first epoch of observations which revealed variability on timescales ranging from hours to days in 85 of 710 compact flat-spectrum sources. The number of highly variable sources, those with RMS flux density variations greater than 4% of the mean, increases with decreasing source flux density but rapid, large amplitude variables such as J1819+3845 are very rare. When compared with a model for the scintillation due to irregularities in a 500 pc thick electron layer, our preliminary results indicate maximum brightness temperatures ~10E+12 K, similar to those obtained from VLBI surveys even though interstellar scintillation is not subject to the same angular resolution limit.Comment: 18 pages, 5 figures. To appear in the Astronomical Journa

The Sedentary Survey of Extreme High Energy Peaked BL Lacs III. Results from Optical Spectroscopy

The multi-frequency Sedentary Survey is a flux limited, statistically well-defined sample of highly X-ray dominated BL Lacertae objects (HBLs) which includes 150 sources. In this paper, the third of the series, we report the results of a dedicated optical spectroscopy campaign that, together with results from other independent optical follow up programs, led to the spectroscopic identification of all sources in the sample. We carried out a systematic spectroscopic campaign for the observation of all unidentified objects of the sample using the ESO 3.6m, the KPNO 4m, and the TNG optical telescopes. We present new identifications and optical spectra for 76 sources, 50 of which are new BL Lac objects, 18 are sources previously referred as BL Lacs but for which no redshift information was available, and 8 are broad emission lines AGNs. We find that the multi-frequency selection technique used to build the survey is highly efficient (about 90%) in selecting BL Lacs objects. We present positional and spectroscopic information for all confirmed BL Lac objects. Our data allowed us to determined 36 redshifts out of the 50 new BL Lacs and 5 new redshifts for the previously known objects. The redshift distribution of the complete sample is presented and compared with that of other BL Lacs samples. For 26 sources without recognizable absorption features, we calculated lower limits to the redshift using a method based on simulated optical spectra with different ratios between jet and galaxy emission. For a subsample of 38 object with high-quality spectra, we find a correlation between the optical spectral slope, the 1.4 GHz radio luminosity, and the Ca H&K break value, indicating that for powerful/beamed sources the optical light is dominated by the non-thermal emission from the jet.Comment: 23 pages, accepted by A&

A simple quality improvement program improves cardiovascular preventive care offered by medical housestaff at a large, urban hospital treating a high-risk inpatient population

L'edifici fou construït l'any 1850, aproximadament.Primer pla, contrapicat, d'un edifici d'habitatges entre mitgeres. Consta de planta baixa, cinc plantes pis i coberta terrat. La composició de la façana té un eix de simetria vertical central, que coincideix amb la posició de l'escala de veïns

Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs.

A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in <i>C. elegans</i>

Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra. Disease loci causing hereditary forms of PD are known, but most cases are attributable to a combination of genetic and environmental risk factors. Increased incidence of PD is associated with rural living and pesticide exposure, and dopaminergic neurodegeneration can be triggered by neurotoxins such as 6-hydroxydopamine (6-OHDA). In C. elegans, this drug is taken up by the presynaptic dopamine reuptake transporter (DAT-1) and causes selective death of the eight dopaminergic neurons of the adult hermaphrodite. Using a forward genetic approach to find genes that protect against 6-OHDA-mediated neurodegeneration, we identified tsp-17, which encodes a member of the tetraspanin family of membrane proteins. We show that TSP-17 is expressed in dopaminergic neurons and provide genetic, pharmacological and biochemical evidence that it inhibits DAT-1, thus leading to increased 6-OHDA uptake in tsp-17 loss-of-function mutants. TSP-17 also protects against toxicity conferred by excessive intracellular dopamine. We provide genetic and biochemical evidence that TSP-17 acts partly via the DOP-2 dopamine receptor to negatively regulate DAT-1. tsp-17 mutants also have subtle behavioral phenotypes, some of which are conferred by aberrant dopamine signaling. Incubating mutant worms in liquid medium leads to swimming-induced paralysis. In the L1 larval stage, this phenotype is linked to lethality and cannot be rescued by a dop-3 null mutant. In contrast, mild paralysis occurring in the L4 larval stage is suppressed by dop-3, suggesting defects in dopaminergic signaling. In summary, we show that TSP-17 protects against neurodegeneration and has a role in modulating behaviors linked to dopamine signaling