A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Levosimendan versus Milrinone for Inotropic Support in Pediatric Cardiac Surgery: Results from a Randomized Trial

Objective : We aimed to determine the differential effects of intra-operative administration of milrinone versus levosimendan on myocardial function after pediatric cardiac surgery. Transthoracic echocardiography was employed for myocardial function evaluation, utilizing biventricular longitudinal strain with two-dimensional speckle tracking echocardiography in addition to conventional echocardiographic variables. Design : A secondary analysis of a randomized, prospective, double-blinded clinical drug trial Setting : Two pediatric tertiary university hospitals Participants : Infants between 1-12 months of age diagnosed with ventricular septal defect, complete atrioventricular septal defect, or tetralogy of Fallot who were scheduled for corrective surgery with cardiopulmonary bypass. Interventions : The patients were randomized to receive an infusion of milrinone or levosimendan at the start of cardiopulmonary bypass and for 26 consecutive hours. Measurements and main results : Biventricular longitudinal strain and conventional echocardiographic variables were measured preoperatively, on the first postoperative morning and prior to hospital discharge. The association between perioperative parameters and postoperative myocardial function was also investigated. Images were analyzed for left ventricular (n=67) and right ventricular (n=44) function. The day after surgery, left ventricular longitudinal strain was deteriorated in both the milrinone and levosimendan groups; 33% and 39%, respectively. The difference was not significant. The corresponding deterioration in right ventricular longitudinal strain was 42% and 50% (non-significant difference). For both groups, biventricular longitudinal strain approached their preoperative values at hospital discharge. Preoperative N-terminal pro-brain natriuretic peptide could predict the left ventricular strain on postoperative day one (p=0.014). Conclusions : Levosimendan was comparable to milrinone for left and right ventricular inotropic support in pediatric cardiac surgery.Peer reviewe

Impact of Artemisinin-Based Combination Therapy and Insecticide-Treated Nets on Malaria Burden in Zanzibar

Zanzibar has implemented artemisinin-based combination therapy for uncomplicated malaria, plus long-lasting insecticidal nets. Achuyt Bhattarai and colleagues found malaria morbidity and mortality decreased dramatically within two years

Molecular layer deposition of "magnesicone", a magnesium-based hybrid material

Molecular layer deposition (MLD) offers the deposition of ultrathin and conformal organic or hybrid films which have a wide range of applications. However, some critical potential applications require a very specific set of properties. For application as desiccant layers in water barrier films, for example, the films need to exhibit water uptake and swelling and be overcoatable. For application as a backbone for a solid composite electrolyte for lithium ions on the other hand, the films need to be stable against lithium and need to be transformable from a hybrid MLD film to a porous metal oxide film. Magnesium-based MLD films, called "magnesicone", are promising on both these aspects, and thus, an MLD process is developed using Mg(MeCp)(2) as a metal source and ethylene glycol (EG) or glycerol (GL) as organic reactants. Saturated growth could be achieved at 2 to 3 angstrom/cycle in a wide temperature window from 100 to 250 degrees C. The resulting magnesicone films react with ambient air and exhibit water uptake, which is in the case of the GL-based films associated with swelling (up to 10%) and in the case of EG-based magnesicone with Mg(CO)(3) formation, and are overcoatable with an ALD of Al2O3. Furthermore, by carefully tuning the annealing rate, the EG-grown films can be made porous at 350 degrees C. Hence, these functional tests demonstrate the potential of magnesicone films as reactive barrier layers and as the porous backbone of lithium ion composite solid electrolytes, making it a promising material for future applications

Understanding and Fostering Collective Ideation: An Improvisation-Based Method

Although the collective view is receiving increasing attention in research, this perspective is missing from the approaches for fostering creativity and ideation. The present study aims to fill this research gap by understanding ideation as a collective phenomenon and by introducing a novel method for fostering collective ideation. The study builds on current research on knowledge creation, collective creativity, idea generation, and collective theatrical improvisation to introduce an approach for fostering collective ideation. In addition, as a secondary goal, the study provides empirical findings about the implementation of collective ideation in 13 distinct cases. The study builds links between knowledge creation and collective theatrical improvisation and, thus, highlights social and affective aspects of collective ideation as a knowledge creation.Post-print / Final draf

A Critical Comparison of Two Creativity Methods for Fostering Participatory Innovation: Implications to Improve TRIZ

We present an empirical study in which we contrast two creativity methods, the lateral thinking method and the improvisational theatre method, to investigate their applicability for advancing participatory innovation. While both of the contrasted methods aim to increase creativity as a means of improving participative innovation, they differ in terms of their conceptualisations of creativity, goals and processes. We propose that these two methods could complement the weaknesses of the TRIZ method (theory of inventive problem solving), especially in cases in which diverse experts gather to innovate, solve problems and generate new knowledge for shared goals. We illustrate the utilisation of the methods by reporting two creative development workshops. The paper sheds light on methods for fostering creative participatory innovation and highlights the collective nature of co-creation in participatory innovation. In addition, the paper suggests how the studied participative co-creative methods could be useful in improving the TRIZ method.Post-print / Final draf