Mortality in Parkinson's disease : A systematic review and meta-analysis

© 2014 International Parkinson and Movement Disorder Society.Peer reviewedPublisher PD

Intermittent reconnection and plasmoids in UV bursts in the low solar atmosphere

Magnetic reconnection is thought to drive a wide variety of dynamic phenomena in the solar atmosphere. Yet the detailed physical mechanisms driving reconnection are difficult to discern in the remote sensing observations that are used to study the solar atmosphere. In this paper we exploit the high-resolution instruments Interface Region Imaging Spectrograph (IRIS) and the new CHROMIS Fabry-Perot instrument at the Swedish 1-m Solar Telescope (SST) to identify the intermittency of magnetic reconnection and its association with the formation of plasmoids in so-called UV bursts in the low solar atmosphere. The Si IV 1403A UV burst spectra from the transition region show evidence of highly broadened line profiles with often non-Gaussian and triangular shapes, in addition to signatures of bidirectional flows. Such profiles had previously been linked, in idealized numerical simulations, to magnetic reconnection driven by the plasmoid instability. Simultaneous CHROMIS images in the chromospheric Ca II K 3934A line now provide compelling evidence for the presence of plasmoids, by revealing highly dynamic and rapidly moving brightenings that are smaller than 0.2 arcsec and that evolve on timescales of order seconds. Our interpretation of the observations is supported by detailed comparisons with synthetic observables from advanced numerical simulations of magnetic reconnection and associated plasmoids in the chromosphere. Our results highlight how subarcsecond imaging spectroscopy sensitive to a wide range of temperatures combined with advanced numerical simulations that are realistic enough to compare with observations can directly reveal the small-scale physical processes that drive the wide range of phenomena in the solar atmosphere.Comment: Accepted for publication in Astrophysical Journal Letters. Movies are available at http://folk.uio.no/rouppe/plasmoids_chromis

Study of the electron trigger efficiency of the CMS Experiment using test beam data

A study of the electron identification and selection efficiency of the L1 Trigger algorithm has been performed using the combined ECAL/HCAL test beam data. A detailed discussion of the electron isolation and its impact on the selection efficiency is presented. The L1 electron algorithm is studied for different beam energies and the results indicate that efficiencies of 98% or more can be achieved for electrons with energies between 15 and 100 GeV. The fraction of charged hadrons with energies from 3 up to 100 GeV rejected by the L1 electron trigger algorithm is estimated to be larger than 93%.Comment: 22 pages, 14 figure

Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators

Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions. The mechanistic basis for insulator activity and how it relates to enhancer action-at-a-distance remains unclear. Here we explore the idea that topological loops could simultaneously account for regulatory interactions of distal enhancers and the insulating activity of boundary elements. We show that while loop formation is not in itself sufficient to explain action at a distance, incorporating transient non-specific and moderate attractive interactions between the chromatin fibers strongly enhances long-distance regulatory interactions and is sufficient to generate a euchromatin-like state. Under these same conditions, the subdivision of the loop into two topologically independent loops by insulators inhibits inter-domain interactions. The underlying cause of this effect is a suppression of crossings in the contact map at intermediate distances. Thus our model simultaneously accounts for regulatory interactions at a distance and the insulator activity of boundary elements. This unified model of the regulatory roles of chromatin loops makes several testable predictions that could be confronted with \emph{in vitro} experiments, as well as genomic chromatin conformation capture and fluorescent microscopic approaches.Comment: 10 pages, originally submitted to an (undisclosed) journal in May 201

Impacts of land-use and land-cover change on stream hydrochemistry in the Cerrado and Amazon biomes

Studies on the impacts of land-use and land-cover change on stream hydrochemistry in active deforestation zones of the Amazon agricultural frontier are limited and have often used low-temporal-resolution datasets. Moreover, these impacts are not concurrently assessed in well-established agricultural areas and new deforestations hotspots. We aimed to identify these impacts using an experimental setup to collect high-temporal-resolution hydrological and hydrochemical data in two pairs of low-order streams in catchments under contrasting land use and land cover (native vegetation vs. pasture) in the Amazon and Cerrado biomes. Our results indicate that the conversion of natural landscapes to pastures increases carbon and nutrient fluxes via streamflow in both biomes. These changes were the greatest in total inorganic carbon in the Amazon and in potassium in the Cerrado, representing a 5.0- and 5.5-fold increase in the fluxes of each biome, respectively. We found that stormflow, which is often neglected in studies on stream hydrochemistry in the tropics, plays a substantial role in the carbon and nutrient fluxes, especially in the Amazon biome, as its contributions to hydrochemical fluxes are mostly greater than the volumetric contribution to the total streamflow. These findings demonstrate that assessments of the impacts of deforestation in the Amazon and Cerrado biomes should also take into account rapid hydrological pathways; however, this can only be achieved through collection of high-temporal-resolution data