7,904 research outputs found
Deformabilidad en hormigones con agregados reciclados
Diversos trabajos han demostrado la factibilidad de elaborar hormigones con agregados reciclados, sin embargo sobre algunos aspectos poco explorados aún existen informaciones contrapuestas. Entre ellos se destacan el comportamiento diferido del hormigón (contracción y fluencia) y la capacidad de deformación en tracción (extensibilidad). Estas propiedades afectan directamente el grado de fisuración que puede tener una estructura de hormigón, lo que adquiere una significativa relevancia en la práctica, al considerar su vida en servicio. En este trabajo se presenta un estudio de la deformabilidad de hormigones que contienen 50 o 100 % de agregado grueso obtenido a partir de la trituración de losas de pavimento. Los resultados se comparan con los de otros dos hormigones elaborados con idénticas proporciones de materiales componentes variando el tipo de agregado grueso, piedra partida granítica o piedra partida cuarcítica. Se evaluaron la resistencia a tracción, la extensibilidad en flexión bajo cargas rápidas, y la fluencia en compresión. Bajo cargas de corta duración se encontró una deformabilidad creciente en el hormigón con mayor contenido de agregados reciclados, tanto en flexotracción como en compresión; también se midieron mayores valores de contracción libre y de fluencia. A partir de los resultados surge que es posible estimar la deformabilidad del hormigón con agregados reciclados siguiendo criterios similares a los aplicados en hormigones con agregados naturales; las diferencias de deformabilidad se pueden justificar considerando la menor rigidez del agregado reciclado.Different works have demonstrated the feasibility of elaborating concrete with recycled aggregates, nevertheless there is still opposite information about some aspects that have not been widely studied. The differed behaviour (shrinkage and creep) and the deformation capacity in tension (extensibility) of concrete are among them. These properties have a direct effect over the degree of cracking that can have a concrete structure so, considering its service life, they acquire a significant relevance in practice. This paper presents a study on the deformability of concretes that contain 50 or 100 % of coarse aggregate obtained from crushed pavement slabs. The results are compared with those obtained on other two concretes prepared with the same mixture proportions varying only the type of coarse aggregate, granitic crushed stone or quartzitic crushed stone. The tensile strength, extensibility in flexure under rapid rate of loading and creep in compression were evaluated. It was found that under short term loads the deformability of concrete increases with the content of recycled aggregates, both in flexure and in compression, grater values of free shrinkage and creep were also measured. From the obtained results it appears that the deformability of concrete with recycled aggregates can be estimated following the same criteria applied to concrete with natural aggregate, the differences in deformability can be justified considering the lower stiffness of the recycled aggregate
On the new economic philosophy of crisis management in the European Union
This essay attempts to go beyond presenting the bits and pieces of still ongoing crisis management in the EU. Instead it attempts at finding the ‘red thread’ behind a series of politically improvised decisions. Our fundamental research question asks whether basic economic lessons learned in the 1970s are still valid. Namely, that a crises emanating from either structural or regulatory weaknesses cannot and should not be remedied by demand management. Our second research question is the following: Can lacking internal commitment and conviction in any member state be replaced or substituted by external pressure or formalized procedures and sanctions? Under those angles we analyze the project on establishing a fiscal and banking union in the EU, as approved by the Council in December 2012
Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma.
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define VSV oncolysis in cancer cells represents a fundamental prerequisite to engineering more effective oncolytic viral vectors and adjusting combination therapies. After having identified defects in the signalling cascade of type I interferon induction, responsible for attenuated antiviral responses in human HCC cell lines, we have now investigated the role of cell proliferation and translation initiation. Cell cycle progression and translation initiation factors eIF4E and eIF2Bepsilon have been recently identified as key regulators of VSV permissiveness in T-lymphocytes and immortalized mouse embryonic fibroblasts, respectively. Here, we show that in HCC, decrease of cell proliferation by cell cycle inhibitors or siRNA-mediated reduction of G(1) cyclin-dependent kinase activities (CDK4) or cyclin D1 protein expression, do not significantly alter viral growth. Additionally, we demonstrate that translation initiation factors eIF4E and eIF2Bepsilon are negligible in sustaining VSV replication in HCC. Taken together, these results indicate that cellular proliferation and the initiation phase of cellular protein synthesis are not essential for successful VSV oncolysis of HCC. Moreover, our observations indicate the importance of cell-type specificity for VSV oncolysis, an important aspect to be considered in virotherapy applications in the future
Statistical Mechanics for Unstable States in Gel'fand Triplets and Investigations of Parabolic Potential Barriers
Free energies and other thermodynamical quantities are investigated in
canonical and grand canonical ensembles of statistical mechanics involving
unstable states which are described by the generalized eigenstates with complex
energy eigenvalues in the conjugate space of Gel'fand triplet. The theory is
applied to the systems containing parabolic potential barriers (PPB's). The
entropy and energy productions from PPB systems are studied. An equilibrium for
a chemical process described by reactions is also
discussed.Comment: 14 pages, AmS-LaTeX, no figur
ELM triggering conditions for the integrated modeling of H-mode plasmas
Recent advances in the integrated modeling of ELMy H-mode plasmas are
presented. A model for the H-mode pedestal and for the triggering of ELMs
predicts the height, width, and shape of the H-mode pedestal and the frequency
and width of ELMs. Formation of the pedestal and the L-H transition is the
direct result of ExB flow shear suppression of anomalous transport. The
periodic ELM crashes are triggered by either the ballooning or peeling MHD
instabilities. The BALOO, DCON, and ELITE ideal MHD stability codes are used to
derive a new parametric expression for the peeling-ballooning threshold. The
new dependence for the peeling-ballooning threshold is implemented in the ASTRA
transport code. Results of integrated modeling of DIII-D like discharges are
presented and compared with experimental observations. The results from the
ideal MHD stability codes are compared with results from the resistive MHD
stability code NIMROD.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004,
Nice (France
Heterogeneities in leishmania infantum infection : using skin parasite burdens to identify highly infectious dogs
Background: The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management. Here, we quantify heterogeneities in Leishmania infantum parasite numbers in reservoir and non-reservoir host populations, and relate this to their infectiousness during natural infection. Tissue parasite number was evaluated as a potential surrogate marker of host transmission potential.
Methods: Parasite numbers were measured by qPCR in bone marrow and ear skin biopsies of 82 dogs and 34 crab-eating foxes collected during a longitudinal study in Amazon Brazil, for which previous data was available on infectiousness (by xenodiagnosis) and severity of infection.
Results: Parasite numbers were highly aggregated both between samples and between individuals. In dogs, total parasite abundance and relative numbers in ear skin compared to bone marrow increased with the duration and severity of infection. Infectiousness to the sandfly vector was associated with high parasite numbers; parasite number in skin was the best predictor of being infectious. Crab-eating foxes, which typically present asymptomatic infection and are non-infectious, had parasite numbers comparable to those of non-infectious dogs.
Conclusions: Skin parasite number provides an indirect marker of infectiousness, and could allow targeted control particularly of highly infectious dogs
Numerical simulations of a non-commutative theory: the scalar model on the fuzzy sphere
We address a detailed non-perturbative numerical study of the scalar theory
on the fuzzy sphere. We use a novel algorithm which strongly reduces the
correlation problems in the matrix update process, and allows the investigation
of different regimes of the model in a precise and reliable way. We study the
modes associated to different momenta and the role they play in the ``striped
phase'', pointing out a consistent interpretation which is corroborated by our
data, and which sheds further light on the results obtained in some previous
works. Next, we test a quantitative, non-trivial theoretical prediction for
this model, which has been formulated in the literature: The existence of an
eigenvalue sector characterised by a precise probability density, and the
emergence of the phase transition associated with the opening of a gap around
the origin in the eigenvalue distribution. The theoretical predictions are
confirmed by our numerical results. Finally, we propose a possible method to
detect numerically the non-commutative anomaly predicted in a one-loop
perturbative analysis of the model, which is expected to induce a distortion of
the dispersion relation on the fuzzy sphere.Comment: 1+36 pages, 18 figures; v2: 1+55 pages, 38 figures: added the study
of the eigenvalue distribution, added figures, tables and references, typos
corrected; v3: 1+20 pages, 10 eps figures, new results, plots and references
added, technical details about the tests at small matrix size skipped,
version published in JHE
Drivers of column-average CO_2 variability at Southern Hemispheric Total Carbon Column Observing Network sites
We investigate factors that drive the variability in total column CO_2 at the Total Carbon Column Observing Network sites in the Southern Hemisphere using fluxes tagged by process and by source region from the CarbonTracker analysed product as well as the Simple Biosphere model. We show that the terrestrial biosphere is the largest driver of variability in the Southern Hemisphere column CO_2. However, it does not dominate in the same fashion as in the Northern Hemisphere. Local- and hemispheric-scale biomass burning can also play an important role, particularly at the tropical site, Darwin. The magnitude of seasonal variability in the column-average dry-air mole fraction of CO_2, X_CO_2, is also much smaller in the Southern Hemisphere and comparable in magnitude to the annual increase. Comparison of measurements to the model simulations highlights that there is some discrepancy between the two time series, especially in the early part of the Darwin data record. We show that this mismatch is most likely due to erroneously estimated local fluxes in the Australian tropical region, which are associated with enhanced photosynthesis caused by early rainfall during the tropical monsoon season
Metamorphosis of plasma turbulence-shear flow dynamics through a transcritical bifurcation
The structural properties of an economical model for a confined plasma
turbulence governor are investigated through bifurcation and stability
analyses. A close relationship is demonstrated between the underlying
bifurcation framework of the model and typical behavior associated with low- to
high-confinement transitions such as shear flow stabilization of turbulence and
oscillatory collective action. In particular, the analysis evinces two types of
discontinuous transition that are qualitatively distinct. One involves
classical hysteresis, governed by viscous dissipation. The other is
intrinsically oscillatory and non-hysteretic, and thus provides a model for the
so-called dithering transitions that are frequently observed. This
metamorphosis, or transformation, of the system dynamics is an important late
side-effect of symmetry-breaking, which manifests as an unusual non-symmetric
transcritical bifurcation induced by a significant shear flow drive.Comment: 17 pages, revtex text, 9 figures comprised of 16 postscript files.
Submitted to Phys. Rev.
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