Takotsubo cardiomyopathy and sepsis: a systematic review

Takotsubo cardiomyopathy (TTC) is characterized by a systolic dysfunction localized in the apical and medial aspect of the left ventricle. It is usually related to physical or emotional stress. Recent evidence highlighting the role of infection led us to analyze the links between TTC and sepsis. A systematic review of the literature was undertaken to assess any trends in clinical findings, diagnosis, and outcomes in such patients. We identified 23 selected papers reporting a total of 26 patients, having sepsis, in whom TTC occurred. For each case, we collected data identifying population characteristics, source of sepsis, clinical disease description, and the results of cardiovascular investigations. The majority of patients were females (n = 16), mean age was 62.8 (14.0 standard deviation) years, and clinical outcome was favorable in 92.3% of the cases once the management of sepsis was initiated. A better understanding of the mechanisms of sepsis-associated TTC may generate novel strategies to treat the complications of this cardiomyopathy and may even help predict and prevent its occurrence

Star Product and Invariant Integration for Lie type Noncommutative Spacetimes

We present a star product for noncommutative spaces of Lie type, including the so called ``canonical'' case by introducing a central generator, which is compatible with translations and admits a simple, manageable definition of an invariant integral. A quasi-cyclicity property for the latter is shown to hold, which reduces to exact cyclicity when the adjoint representation of the underlying Lie algebra is traceless. Several explicit examples illuminate the formalism, dealing with kappa-Minkowski spacetime and the Heisenberg algebra (``canonical'' noncommutative 2-plane).Comment: 21 page

Crystal structure of monomeric human β-2- microglobulin reveals clues to its amyloidogenic properties

Dissociation of human β-2-microglobulin (β(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein. As a consequence of renal failure, the concentration of circulating monomeric β(2)m increases, ultimately leading to deposition of the protein into amyloid fibrils and development of the disorder, dialysis-related amyloidosis. Here we present the crystal structure of a monomeric form of human β(2)m determined at 1.8-Å resolution that reveals remarkable structural changes relative to the HLA-bound protein. These involve the restructuring of a β bulge that separates two short β strands to form a new six-residue β strand at one edge of this β sandwich protein. These structural changes remove key features proposed to have evolved to protect β sheet proteins from aggregation [Richardson, J.&Richardson, D. (2002) Proc. Natl. Acad. Sci. USA 99, 2754–2759] and replaces them with an aggregationcompetent surface. In combination with solution studies using (1)H NMR, we show that the crystal structure presented here represents a rare species in solution that could provide important clues about the mechanism of amyloid formation from the normally highly soluble native protein

A Framework for Reliability and Safety Analysis of Complex Space Missions

Long duration and complex mission scenarios are characteristics of NASA's human exploration of Mars, and will provide unprecedented challenges. Systems reliability and safety will become increasingly demanding and management of uncertainty will be increasingly important. NASA's current pioneering strategy recognizes and relies upon assurance of crew and asset safety. In this regard, flexibility to develop and innovate in the emergence of new design environments and methodologies, encompassing modeling of complex systems, is essential to meet the challenges

U.S. Opioid Epidemic: Challenges and Opportunities for Evidence-based Policies

Recent data from the Centers for Disease Control and Prevention (CDC) indicated that on average, 130 Americans die every day from opioid-related overdose. For the first time, more Americans are dying from opioids than from guns, car accidents or breast cancer. “Every 8 minutes, someone in America dies from a drug overdose; usually from opioids such as, heroin, illicit fentanyl, or oxycodone, hydrocodone, morphine and hydromorphine prescribed by doctors.” Specifically, prescription opioids account for approximately 40%-70% of fatal and non-fatal overdoses, and are frequently the first opioids encountered by individuals before transitioning to illicit drugs. In response to this public health epidemic, a number of policies have been enacted to mitigate the problem. However, some policies may “prevent patients who need opioids from getting them, turn providers into policemen when patients seek opioids, and police providers themselves when they prescribe opioids.” Difficulty of accessing prescription opioids may contribute to increased demand for illegal narcotics, such as heroin and illicitly manufactured fentanyl (IMF). Herein lies the challenge of reversing the opioid epidemic while ensuring access to safe opioid treatment. This document reviews policy approaches to addressing the epidemic, and considers opportunities for evidence-based strategies

The subcortical role in executive functions: Neural mechanisms of executive inhibition in the flanker task

While executive functions (EFs) have traditionally been linked to the cerebral cortex, our understanding of EFs has evolved with increasing evidence pointing to the involvement of cortico-subcortical networks. Despite the importance of investigating EFs within this broader context, the functional contributions of subcortical regions to these processes remain largely unexplored. This study addresses this gap by specifically examining the involvement of subcortical regions in executive inhibition, as measured by the classic Eriksen flanker task. In this study, we used a stereoscope to differentiate between subcortical (monocular) and cortical (mostly binocular) visual pathways in EF processes. Our findings indicate that monocular visual pathways play a crucial role in representing executive conflict, which necessitates cortical involvement. The persistence of a monoptic advantage in conflict representation highlights the substantial contribution of subcortical regions to these executive processes. This exploration of subcortical involvement in executive inhibition provides valuable insights into the intricate relationships between cortical and subcortical regions in EFs

On Superdeterministic Rejections of Settings Independence

Relying on some auxiliary assumptions, usually considered mild, Bell's theorem proves that no local theory can reproduce all the predictions of quantum mechanics. In this work, we introduce a fully local, superdeterministic model that, by explicitly violating settings independence--one of these auxiliary assumptions, requiring statistical independence between measurement settings and systems to be measured--is able to reproduce all the predictions of quantum mechanics. Moreover, we show that, contrary to widespread expectations, our model can break settings independence without an initial state that is too complex to handle, without visibly losing all explanatory power and without outright nullifying all of experimental science. Still, we argue that our model is unnecessarily complicated and does not offer true advantages over its non-local competitors. We conclude that, while our model does not appear to be a viable contender to their non-local counterparts, it provides the ideal framework to advance the debate over violations of statistical independence via the superdeterministic route.Comment: 38 pages, 2 figure

Mathematical anxiety is associated with reduced visuospatial working memory: The impact of emotional and spatial distracting information

The attentional control theory posits that anxiety may shift attention towards threatening stimuli and/or affect general attentional control mechanisms. The spatial theory suggests that mathematical anxiety (MA) originates from weakness in spatial processing mechanisms such as visuospatial working memory. Accordingly, MA may negatively influence (1) attentional mechanisms in anxious states and/or (2) general attentional control or working memory mechanisms. The current study examined the associations between MA, attention mechanisms, and working memory. To this end, we validated a new set of math-related pictures and used a math-related modified version of a flanker task. Two groups of college students with low (N = 35) and high (N = 31) MA were asked to perform a central task and ignore math-related and neutral distracting pictures. After we controlled for general anxiety, participants with high MA exhibited a larger location congruency effect in the modified flanker task. Moreover, visuospatial short-term and working memory fully mediated the relationship between MA and performances. These results suggest that general visuospatial deficits constitute the main difficulty among individuals with MA. Taken together, the findings shed light on the unique difficulty of individuals with HMA ignoring distraction, and suggest that reduced visuospatial abilities are at the basis of this difficulty. These findings are discussed in the context of their theoretical and treatment-related potential implications