Evaluating spatial normalization methods for the human brain

Cortical stimulation mapping (CSM) studies have shown cortical locations for language function are highly variable from one subject to the next. If individual variation can be normalized, patterns of language organization may emerge that were heretofore hidden. In order to uncover this pattern, computer-aided spatial normalization to a common atlas is required. Our problem was how to determine which spatial normalization method was best for the given research application. We developed key metrics to measure accuracy of a surface-based (Caret) and volume-based (SPM2) method. We specified that the optimal method would i) minimize variation as measured by spread reduction between CSM language sites across subjects while also ii) preserving anatomical localization of all CSM sites. Eleven subject’s structural MR data and corresponding CSM site coordinates were registered to the colin27 human brain atlas using each method. Local analysis showed that mapping error rates for both methods were highest in morphological regions with the greatest difference between source and target. Also, SPM2 mapped significantly less type 2 errors. Although our experiment did not show statistically significant global differences between the methods, our methodology provided valuable insights into the pros and cons of each

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression.

Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which comprise <1% of the genome. Here we leverage a compendium of 58,648 long noncoding RNAs (lncRNAs) to subtype 947 breast cancer samples. We show that lncRNA-based profiling categorizes breast tumours by their known molecular subtypes in breast cancer. We identify a cohort of breast cancer-associated and oestrogen-regulated lncRNAs, and investigate the role of the top prioritized oestrogen receptor (ER)-regulated lncRNA, DSCAM-AS1. We demonstrate that DSCAM-AS1 mediates tumour progression and tamoxifen resistance and identify hnRNPL as an interacting protein involved in the mechanism of DSCAM-AS1 action. By highlighting the role of DSCAM-AS1 in breast cancer biology and treatment resistance, this study provides insight into the potential clinical implications of lncRNAs in breast cancer

Thermodynamic aspects of materials' hardness: prediction of novel superhard high-pressure phases

In the present work we have proposed the method that allows one to easily estimate hardness and bulk modulus of known or hypothetical solid phases from the data on Gibbs energy of atomization of the elements and corresponding covalent radii. It has been shown that hardness and bulk moduli of compounds strongly correlate with their thermodynamic and structural properties. The proposed method may be used for a large number of compounds with various types of chemical bonding and structures; moreover, the temperature dependence of hardness may be calculated, that has been performed for diamond and cubic boron nitride. The correctness of this approach has been shown for the recently synthesized superhard diamond-like BC5. It has been predicted that the hypothetical forms of B2O3, diamond-like boron, BCx and COx, which could be synthesized at high pressures and temperatures, should have extreme hardness

Technique of the Fast Ferrofluids Simulation

We present a highly-parallel implementation of the Langevin simulation method for modeling ferrofluids on Graphical Processor Units (GPU). Our method is based on the Barnes-Hut algorithm. As a benchmark we use the straightforward 'all-to-all interaction' algorithm. The obtained results are in good agreement with known theoretical model. With the proposed method we were able to follow the evolution of a system of one million interacting particles over long time-scales, the task hitherto is out of reach with the standard, CPU-based numerical schemes. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3534

Mechanisms of light energy harvesting in dendrimers and hyperbranched polymers

Since their earliest synthesis, much interest has arisen in the use of dendritic and structurally allied forms of polymer for light energy harvesting, especially as organic adjuncts for solar energy devices. With the facility to accommodate a proliferation of antenna chromophores, such materials can capture and channel light energy with a high degree of efficiency, each polymer unit potentially delivering the energy of one photon-or more, when optical nonlinearity is involved. To ensure the highest efficiency of operation, it is essential to understand the processes responsible for photon capture and channelling of the resulting electronic excitation. Highlighting the latest theoretical advances, this paper reviews the principal mechanisms, which prove to involve a complex interplay of structural, spectroscopic and electrodynamic properties. Designing materials with the capacity to capture and control light energy facilitates applications that now extend from solar energy to medical photonics. © 2011 by the authors; licensee MDPI, Basel, Switzerland

The \u3cem\u3eChlamydomonas\u3c/em\u3e Genome Reveals the Evolution of Key Animal and Plant Functions

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella

Комп’ютерне моделювання характеристик одноелектронних транзисторів

Proposed methods of modeling of electrical and temperature characteristics of single-electrontransistor for providing information to system of computer-aided design Electronics Workbench.Analyzed dependence in current-voltage characteristics of nano-device trough values of temperature andoperating modeРазработаны методы моделирования электрических и температурных характеристик одноэлектронного транзистора для информационного обеспечения системы автоматизированного схемотехническогопроектирования Electronics Workbench. Проанализирована зависимость вольт-амперных характеристик наноприбора от влияния температуры и рабочего режимаРозроблено методи моделювання електричних та температурних характеристик одноелектронного транзистора для інформаційного забезпечення системи автоматизованого схемотехнічного проектування Electronics Workbench. Проаналізовано залежність вольт-амперних характеристик наноприладу від впливу температури таробочого режим

«Реестры» книг частных библиотек первой половины XVIII в. из материалов конфискационной комиссии Елизаветы Петровны (1742–1743 гг.)

This article presents a catalogue of books from the private libraries of counts A. I. Osterman, M. G. Golovkin, B.-Ch. Minnich, and baron K. L. Mengden. These books were confiscated after the coup d’état (25 November 1741) as a part of their property and then were transferred to the Library of the Academy of Sciences in accordance with Empress Elizabeth’s order in 1742–43. On 1 December 1741, «The record Commission for Osterman’s and others’ movable property, villages and debt obligations» was established. One of its tasks was to allocate the books to different institutions such as the Collegium of Foreign Affairs and the Library of the Academy of Sciences. The rest of the books were sold. The religious books belonging to A. I. Osterman and M. G. Golovkin were given to the Church of the Resurrection in the grounds of Pokrov Palace in Moscow. DOI: 10.31168/2305-6754.2020.9.1.16В статье публикуется реестр книг из домашних библиотек графов А. И. Остермана, М. Г. Головкина, Б.-Х. Миниха, барона К. Л. Менгдена, переданных в фонды Библиотеки Академии наук в начале — середине 40-х гг. XVIII в. по указу императрицы Елизаветы Петровны. Книжные собрания указанных государственных деятелей были конфискованы вместе с другим имуществом после дворцового переворота 25 ноября 1741 г. Образованная 1 декабря 1741 г. «Комиссия описи пожитков, деревень и разобрания долгов Остермана и протчих» должна была распределить книжные издания и рукописи между учреждениями. Части конфискованных книг поступили в Коллегию иностранных дел и Библиотеку Академии наук, а оставшиеся экземпляры были распроданы. Комплекс церковных книг графов А. И. Остермана и М. Г. Головкина попал на хранение в Воскресенскую церковь Покровского дворца в Москве. DOI: 10.31168/2305-6754.2020.9.1.1