Effects of mistuning on dynamic behavior of nonlinear cyclic systems with lump masses and cubic nonlinearity

Mistuning in cyclic symmetric systems increases severely the forced response of system and splits the modes. This paper concerns with nonlinear behavior of mistuned cyclic systems. A nonlinear, mistuned model based on the method of multiple scales is proposed and formulated in which nonlinearity and mistuning parameter is assumed to be in of low order. Next, two mistuned systems were considered and solved by the multiple scale technique. Numerical results demonstrate that mistuning can lead to repeating and scattering of jump phenomena during the excitation frequency whereas in tuned cyclic system it occurs simultaneously (synchronously).Peer ReviewedPostprint (published version

A new operational matrix based on Bernoulli polynomials

In this research, the Bernoulli polynomials are introduced. The properties of these polynomials are employed to construct the operational matrices of integration together with the derivative and product. These properties are then utilized to transform the differential equation to a matrix equation which corresponds to a system of algebraic equations with unknown Bernoulli coefficients. This method can be used for many problems such as differential equations, integral equations and so on. Numerical examples show the method is computationally simple and also illustrate the efficiency and accuracy of the method

Does soy protein supplementation affect body composition in healthy exerciser adults? A systematic review and meta-analysis of clinical trials

Background objectives: The effects of soy protein supplementation on anthropometric parameters and body composition indices of healthy adults is equivocal. The aims of this systematic review and meta-analysis were to assess the effects of soy protein supplementation on weight and body composition of healthy adults in clinical trial studies. Methods: A systematic search of literature was carried out on clinical trial studies in PubMed, Scopus, Cochrane's library and ISI Web of Science Direct up until November 2017. From 492 studies initially retrieved, only 8 articles with 6, 5 and 4 arms included in the meta-analysis of the effects of soy protein supplementation on body weight, Fat free mass and Fat mass, respectively, with 120 participants in the intervention group and 119 participants in the control group. Results: Results of the fixed effect model meta-analysis showed that soy protein supplementation had no significant effects on body weight (0.94 kg, 95 CI: �2.41, 4.30 kg; P = 0.58), fat-free mass (0.6 kg, 95 CI: �0.21, 1.41; P = 0.14) or fat mass (0.43 kg, 95 CI: �2.18, 3.03; P = 0.74) in healthy exercising adults. Conclusions: Results of this meta-analysis study does not confirm any significant beneficial effects of soy protein supplementation on weight and body composition in healthy adults. © 201

Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture

This work is licensed under a Creative Commons Attribution 3.0 Unported License.-- et al.Advances in sequencing technologies are giving unprecedented insights into the spectrum of somatic mutations underlying acute myeloid leukaemia with a normal karyotype (AML-NK). It is clear that the prognosis of individual patients is strongly influenced by the combination of mutations in their leukaemia and that many leukaemias are composed of multiple subclones, with differential susceptibilities to treatment. Here, we describe a method, employing targeted capture coupled with next-generation sequencing and tailored bioinformatic analysis, for the simultaneous study of 24 genes recurrently mutated in AML-NK. Mutational analysis was performed using open source software and an in-house script (Mutation Identification and Analysis Software), which identified dominant clone mutations with 100% specificity. In each of seven cases of AML-NK studied, we identified and verified mutations in 2-4 genes in the main leukaemic clone. Additionally, high sequencing depth enabled us to identify putative subclonal mutations and detect leukaemia-specific mutations in DNA from remission marrow. Finally, we used normalised read depths to detect copy number changes and identified and subsequently verified a tandem duplication of exons 2-9 of MLL and at least one deletion involving PTEN. This methodology reliably detects sequence and copy number mutations, and can thus greatly facilitate the classification, clinical research, diagnosis and management of AML-NK.We acknowledge the use of the National Institute of Health Research (NIHR) Biomedical Research Centre, University of Cambridge. We thank Drs J Craig and C Crawley of Cambridge University NHS Hospitals trust for allowing us to approach their patients for samples. GV is funded by a Wellcome Trust Senior Fellowship in Clinical Science. Work in GV’s laboratory is also funded by Leukaemia Lymphoma Research and the Kay Kendal Leukaemia Fund.Peer Reviewe

Feeding regime of Persian sturgeon (Acipenser persicus) in the south Caspian Sea

Feeding regime of the Persian sturgeon in the southern basins of the Caspian Sea was studied in summer and winter 2006 in three provinces Guilan, Mazandaran and Golestan. We caught 52 fish specimens in 85 sampling sites varying in depths from 2-100 m using bottom trawls. The average weight and length of fish specimens were 332.81+1 g and 37.69±1 cm, respectively. The alimentary tract of fishes were analyzed and 11 food items including Gobiidae, Gammaridae, Mysidae, Nereidae, Ampharetidae, Pseudocumidae, Clupeidae, Syngnathidae, Scrobicularidae, insects and Cardiidae were identified. The highest feed diversity was observed in Mazandaran province (9 items) and the lowest in the Golestan province (4 items). Although Nereids showed the highest percentage of benthic organisms (49%) but they were of secondary and tertiary importance in the fish diet qualitatively. Comparison of Fulton's condition factor of fishes in the three provinces showed a similar pattern (0.3<1(<0.4). A tukey test revealed that there were no statistically significant differences between condition factor and gastrosomatic index in the three provinces while Vacuity index (CV) showed significant statistical differences among the provinces