Winds and radiation in unison: a new semi-analytic feedback model for cloud dissolution

Star clusters interact with the interstellar medium (ISM) in various ways, most importantly in the destruction of molecular star-forming clouds, resulting in inefficient star formation on galactic scales. On cloud scales, ionizing radiation creates \hii regions, while stellar winds and supernovae drive the ISM into thin shells. These shells are accelerated by the combined effect of winds, radiation pressure and supernova explosions, and slowed down by gravity. Since radiative and mechanical feedback is highly interconnected, they must be taken into account in a self-consistent and combined manner, including the coupling of radiation and matter. We present a new semi-analytic one-dimensional feedback model for isolated massive clouds ($\geq 10^5\,M_{\odot}$) to calculate shell dynamics and shell structure simultaneously. It allows us to scan a large range of physical parameters (gas density, star formation efficiency, metallicity) and to estimate escape fractions of ionizing radiation $f_{\rm{esc,i}}$, the minimum star formation efficiency $\epsilon_{\rm{min}}$ required to drive an outflow, and recollapse time scales for clouds that are not destroyed by feedback. Our results show that there is no simple answer to the question of what dominates cloud dynamics, and that each feedback process significantly influences the efficiency of the others. We find that variations in natal cloud density can very easily explain differences between dense-bound and diffuse-open star clusters. We also predict, as a consequence of feedback, a $4-6$ Myr age difference for massive clusters with multiple generations.Comment: 17 pages, 11 figures (additional 4 pages and 33 figures in appendix), Accepted MNRAS June 15, 201

A remembrance of things (best) forgotten: The 'allegorical past' and the feminist imagination

This is the author's PDF version of an article published in Feminist theology© 2012. The definitive version is available at http://fth.sagepub.com/This article discusses the US TV series Mad Men, which is set in an advertising agency in 1960s New York, in relation to two key elements which seem significant for a consideration of the current state of feminism in church and academy, both of which centre around what it means to remember or (not) to forget

The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction Strand Localization and Scaffolding Properties

The proper cellular location and sealing of tight junctions is assumed to depend on scaffolding properties of ZO-1, a member of the MAGUK protein family. ZO-1 contains a conserved SH3-GUK module that is separated by a variable region (unique-5), which in other MAGUKs has proven regulatory functions. To identify motifs in ZO-1 critical for its putative scaffolding functions, we focused on the SH3-GUK module including unique-5 (U5) and unique-6 (U6), a motif immediately C-terminal of the GUK domain. In vitro binding studies reveal U5 is sufficient for occludin binding; U6 reduces the affinity of this binding. In cultured cells, U5 is required for targeting ZO-1 to tight junctions and removal of U6 results in ectopically displaced junction strands containing the modified ZO-1, occludin, and claudin on the lateral cell membrane. These results provide evidence that ZO-1 can control the location of tight junction transmembrane proteins and reveals complex protein binding and targeting signals within its SH3-U5-GUK-U6 region. We review these findings in the context of regulated scaffolding functions of other MAGUK protein

Laser-induced fluorescence of free diamondoid molecules

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.We observe the fluorescence of pristine diamondoids in the gas phase, excited using narrow band ultraviolet laser light. The emission spectra show well- defined features, which can be attributed to transitions from the excited electronic state into different vibrational modes of the electronic ground state. We assign the normal modes responsible for the vibrational bands, and determine the geometry of the excited states. Calculations indicate that for large diamondoids, the spectral bands do not result from progressions of single modes, but rather from combination bands composed of a large number of Delta v = 1 transitions. The vibrational modes determining the spectral envelope can mainly be assigned to wagging and twisting modes of the surface atoms. We conclude that our theoretical approach accurately describes the photophysics in diamondoids and possibly other hydrocarbons in general.DFG, FOR 1282, Controlling the electronic structure of semiconductor nanoparticles by doping and hybrid formatio

First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis

Evidence for prognosis and treatment of elderly patient with primary central nervous system is limited. High-dose methotrexate should be applied whenever possible, especially combination with oral alkylating agents is a promising approach. Further combinations with other intravenous drugs do not seem to improve outcome. More prospective trials designed for elderly PCNSL patients are warrante