Ferromagnetism in the Periodic Anderson Model - a Modified Alloy Analogy

We introduce a new aproximation scheme for the periodic Anderson model (PAM). The modified alloy approximation represents an optimum alloy approximation for the strong coupling limit, which can be solved within the CPA-formalism. Zero-temperature and finite-temperature phase diagrams are presented for the PAM in the intermediate-valence regime. The diversity of magnetic properties accessible by variation of the system parameters can be studied by means of quasiparticle densities of states: The conduction band couples either ferro- or antiferromagneticaly to the f-levels. A finite hybridization is a necessary precondition for ferromagnetism. However, too strong hybridization generally suppresses ferromagnetism, but can for certain system parameters also lead to a semi-metallic state with unusual magnetic properties. By comparing with the spectral density approximation, the influence of quasiparticle damping can be examined.Comment: 20 pages, 13 figure

Approximate Nearest Neighbour Field Computation and Applications

Approximate Nearest-Neighbour Field (ANNF\ maps between two related images are commonly used by computer vision and graphics community for image editing, completion, retargetting and denoising. In this work we generalize ANNF computation to unrelated image pairs. For accurate ANNF map computation we propose Feature Match, in which the low-dimensional features approximate image patches along with global colour adaptation. Unlike existing approaches, the proposed algorithm does not assume any relation between image pairs and thus generalises ANNF maps to any unrelated image pairs. This generalization enables ANNF approach to handle a wider range of vision applications more efficiently. The following is a brief description of the applications developed using the proposed Feature Match framework. The first application addresses the problem of detecting the optic disk from retinal images. The combination of ANNF maps and salient properties of optic disks leads to an efficient optic disk detector that does not require tedious training or parameter tuning. The proposed approach is evaluated on many publicly available datasets and an average detection accuracy of 99% is achieved with computation time of 0.2s per image. The second application aims to super-resolve a given synthetic image using a single source image as dictionary, avoiding the expensive training involved in conventional approaches. In the third application, we make use of ANNF maps to accurately propagate labels across video for segmenting video objects. The proposed approach outperforms the state-of-the-art on the widely used benchmark SegTrack dataset. In the fourth application, ANNF maps obtained between two consecutive frames of video are enhanced for estimating sub-pixel accurate optical flow, a critical step in many vision applications. Finally a summary of the framework for various possible applications like image encryption, scene segmentation etc. is provided

Protein composition-functionality relationships using novel genetic lines

Doctor of PhilosophyDepartment of Grain Science and IndustryFinlay I. MacRitchieNovel genetic materials were used to deduce gluten protein composition-functionality relationships. The Pegaso bread wheat near-isogenic lines (NILs) included addition, variation and/or deletion of major loci coding for HMW-GS, LMW-GS and gliadins. The waxy wheat lines (Svevo and N11 set) included wild, partial and complete waxy lines. Triticale translocations include 1R.1D and 1A.1D lines (GDS7, Trim, Rhino and Rigel sets) with HMW-GS 5+10 and 2+12. The main goal of the study was to establish the usefulness of NILs as appropriate materials to investigate the structure-function relationships of wheat proteins and to evaluate the performance of unique triticale translocations and waxy wheat lines. Effect of genetic variation on phytochemical (phenolic acid and policosanol) contents was also studied. Innovative methods like MALLS, Lab-on-a-chip and micro (10 g) baking were utilized along with traditional analytical methods. Results confirmed the potential of using NILs in understanding the effects of certain proteins coded at specific loci that might often be targeted in breeding programs. Removal of expected chain terminators at Gli-1/Gli-2 loci causes a shift in MWD to higher values, reflected in higher UPP and dough strength. Lines with HMW-GS 5+10 were clearly separated from 2+12 lines in terms of dough strength and UPP. The present study obtained evidence that modified ω-gliadins acts as chain terminators and cause reduction of protein polymer size and thus shifts in MWD. Marked differences in terms of milling characteristics, protein composition and ultimately in end-use functionality were observed with various waxy wheat null lines. Loaf volumes with waxy wheat flour alone were higher than a 50% blend with commercial wheat; however, breads were unacceptable to consumers in all aspects. Poor milling quality, very low mixing times with low bread loaf volumes were typical of all the triticales studied. However, translocation of the HMW-GS from wheat chromosome 1D increased dough strength, particularly the HMW-GS 5+10. Among the phytochemicals studied, double nulls at Gli-1 loci of Pegaso NILs had the highest total policosanols and total phenolic acid contents.Slight variation to wheat phenolic acid composition and contents were observed with waxy wheat and triticale lines

ALGORITHMS FOR CONSTRUCTING EDGE MAGIC TOTAL LABELING OF COMPLETE BIPARTITE GRAPHS

The study of graph labeling has focused on finding classes of graphs which admits a particular type of labeling. In this paper we consider a particular class of graphs which demonstrates Edge Magic Total Labeling. The class we considered here is a complete bipartite graph Km,n. There are various graph labeling techniques that generalize the idea of a magic square has been proposed earlier. The definition of a magic labeling on a graph with v vertices and e edges is a one to one map taking the vertices and edges onto the integers 1,2,3,………, v+e with the property that the sum of the label on an edge and the labels of its endpoints is constant independent of the choice of edge. We use m x n matrix to construct edge magic total labeling of Km,n

Enhancement of observability using Kubernetes operator

Observability is the ability for us to monitor the state of the system, which involves monitoring standard metrics like central processing unit (CPU) utilization, memory usage, and network bandwidth. The more we can understand the state of the system, the better we can improve the performance by recognizing unwanted behavior, improving the stability and reliability of the system. To achieve this, it is essential to build an automated monitoring system that is easy to use and efficient in its working. To do so, we have built a Kubernetes operator that automates the deployment and monitoring of applications and notifies unwanted behavior in real time. It also enables the visualization of the metrics generated by the application and allows standardizing these visualization dashboards for each type of application. Thus, it improves the system's productivity and vastly saves time and resources in deploying monitored applications, upgrading Kubernetes resources for each application deployed, and migration of applications

Pirfenidone Induced Photosensitivity Reaction in a Patient with Idiopathic Pulmonary Fibrosis

Drug-induced photosensitivity refers to the development of cutaneous disease as a result of combined effects of a chemical and light. Photosensitivity reactions may result from systemic medications and topically applied compounds. Pirfenidone is known to cause photosensitivity reactions, rash, pruritus and dry skin at high doses. However, similar adverse reactions with low doses of Pirfenidone have not been reported. We report a case of photosensitivity reaction induced by low- dose Pirfenidone in a patient with idiopathic pulmonary fibrosis (IPF)

Robustness of the Process of Nucleoid Exclusion of Protein Aggregates in Escherichia coli

Portuguese Foundation for Science and Technology provided funding to Jose Fonseca under grant number PTDC/BBB-MET/1084/2012. Academy of Finland vertical bar Biotieteiden ja Ympariston Tutkimuksen Toimikunta (Forskningsradet for Biovetenskap och Miljo) provided funding to Andre S. Ribeiro under grant number 257603.UNLABELLED: Escherichia coli segregates protein aggregates to the poles by nucleoid exclusion. Combined with cell divisions, this generates heterogeneous aggregate distributions in subsequent cell generations. We studied the robustness of this process with differing medium richness and antibiotics stress, which affect nucleoid size, using multimodal, time-lapse microscopy of live cells expressing both a fluorescently tagged chaperone (IbpA), which identifies in vivo the location of aggregates, and HupA-mCherry, a fluorescent variant of a nucleoid-associated protein. We find that the relative sizes of the nucleoid's major and minor axes change widely, in a positively correlated fashion, with medium richness and antibiotic stress. The aggregate's distribution along the major cell axis also changes between conditions and in agreement with the nucleoid exclusion phenomenon. Consequently, the fraction of aggregates at the midcell region prior to cell division differs between conditions, which will affect the degree of asymmetries in the partitioning of aggregates between cells of future generations. Finally, from the location of the peak of anisotropy in the aggregate displacement distribution, the nucleoid relative size, and the spatiotemporal aggregate distribution, we find that the exclusion of detectable aggregates from midcell is most pronounced in cells with mid-sized nucleoids, which are most common under optimal conditions. We conclude that the aggregate management mechanisms of E. coli are significantly robust but are not immune to stresses due to the tangible effect that these have on nucleoid size. IMPORTANCE: Escherichia coli segregates protein aggregates to the poles by nucleoid exclusion. From live single-cell microscopy studies of the robustness of this process to various stresses known to affect nucleoid size, we find that nucleoid size and aggregate preferential locations change concordantly between conditions. Also, the degree of influence of the nucleoid on aggregate positioning differs between conditions, causing aggregate numbers at midcell to differ in cell division events, which will affect the degree of asymmetries in the partitioning of aggregates between cells of future generations. Finally, we find that aggregate segregation to the cell poles is most pronounced in cells with mid-sized nucleoids. We conclude that the energy-free process of the midcell exclusion of aggregates partially loses effectiveness under stressful conditions.publishersversionpublishe

Thioridazine: a potential adjuvant in pharmacotherapy of drug resistant tuberculosis Ki

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Despite advances in control strategies, inadequate treatment and failure to comply with drug regimens have resulted in TB to emerge as one of the most common and deadly infectious diseases worldwide. The emergence of drug-resistant TBhas evolved as a formidable obstacle for comprehensive TB control. Drug-resistant TB can be classified as multi-drug-resistant TB, extensively drug-resistant TB and totally drug resistant TB (TDR-TB). There is a paucity in the development of new drugs against drug-resistant mycobacteria. The focus has shifted to the exploration of anti-mycobacterial properties of drugs approved for other indications. Thioridazine, a drug approved for use in schizophrenia is one such potential agent, which has shown anti-mycobacterial activity. There is evidence of anti-mycobacterial action of Thioridazine in in-vitro and mouse models. There is a compelling need for new anti-mycobacterial drugs that are more effective and have less toxicity. Further clinical trials are advocated favoring the use of thioridazine as an adjuvant in the treatment of TB, especially TDR-TB

Arthroscopic fixation of comminuted bony bankart lesion with repair of massive retracted rotator cuff tear-A Technical note

Managing concomitant cuff tears with comminuted bony bankart is a challenging scenario. Appropriate management of bony pathology and the rotator cuff ear is necessary in cases associated with both. Bony Bankart with considerable glenoid involvement results in recurrent instability if not treated accordingly. We describe our preferred technique of bony bankart repair with rotator cuff repair in a seventy years old male diagnosed with a large comminuted bony bankart lesion along with a massive cuff tear