Growth traits of the Dorper sheep. II. Genetic and phenotypic parameters

Presents results of a study undertaken at Magogo, Kenya, to analyse genetic and phenotypic correlations between adjacent weights, between weights and rates of growth, and among growth rates themselves, hence data on 969 lambs collected over a 10-year period (1978-1987) on Dorper sheep were used in the study. Lamb traits studied were weights from birth to yearling and absolute growth rates between adjacent stages of growth

Valuing indigenous cattle breeds in Kenya: An empirical comparison of stated and revealed preference value estimates

In this study we compare revealed and stated-preference approaches to value live-stock traits of cattle in Kenya. The premise is that much can be learnt about non-market values of indigenous animal genetic resources (AnGRs) from the use of multi-attribute stated-preference methods, if these compare well with revealed-preference results. The objective is to investigate the performance of choice experiments (CEs) in Maasai cattle trading, by conducting an external test of preference consistency. This involves comparing value estimates for cattle attributes derived from CEs data with those obtained using a hedonic analysis of actual transactions by the same population of traders, in the same markets and over the same period. If CEs perform well, they can be used to investigate values of those genetically-determined livestock traits currently not prominent in pastoralists' populations, but desirable candidates for breeding or conservation programmes (e.g. disease resistance). It is argued that these methods are important in developing countries where livestock are kept for economic reasons and for cultural and risk management functions which are critical to livelihood strategies, but not valued by markets. The results indicate that CEs estimates pass the external test and appear to be adequately precise in estimating values for cattle traits that are relevant in market transactions for Maasai traders. They may be, therefore, a promising tool for valuing phenotypic traits expressed by indigenous AnGRs

Survey Evidence on Conditional Norm Enforcement

We discuss survey evidence on individuals' willingness to sanction norm violations - such as evading taxes, drunk driving, fare dodging, or skiving o work - by expressing disapproval or social exclusion. Our data suggest that people condition their sanctioning behavior on their belief about the frequency of norm violations. The more commonly a norm violation is believed to occur, the lower the individuals' inclination to punish it. Based on an instrumental variable approach, we demonstrate that this pattern reflects a causal relationship

Benchmarking VisualStudio.NET for the development and implementation of a manufacturing execution system

The focus of this thesis is to show the utility of Microsoft\u27s\u27 .NET framework in developing and implementing a MES system. The manufacturing environment today, more than ever, is working towards achieving better yields, productivity, quality, and customer satisfaction. Companies such as DELL are rapidly outgrowing their competition due to better management of their product lifecycles. The time between receiving a new order to the time the final product is shipped is getting shorter. Historically, business management applications such as Enterprise Resource Planning (ERP) systems and Customer Relationship Management (CRM) systems have been implemented without too much importance given to the operational and shop floor needs. The fact is that these business systems can be successful only when they are properly integrated with real-time data from the shop floor, which is the core of any manufacturing set-up. A Manufacturing Execution System or a MES is this link between the shop floor and the top floor. MESA international defines MES as Systems that deliver information enabling the optimization of production activities from order launch to finished goods Thus, a MES provides the right information to the right people at the right time in a right format, to help them make well-informed decisions. Thus, a necessity for an efficient MES is high capability of integration with the existing systems on the operational level. This is where Microsoft\u27s\u27 VS.NET fits in. Microsoft defines .NET as A set of software technologies for connecting information, people, systems and devices . The vision of .NET is to enable the end user to connect to information from any place at anytime, using any device and in a manner that is independent of the platform on which the service is based. The building block of the .NET framework is the Common Language Runtime or CLR, which is capable of converting data from its original format into a format understandable to .NET and then use that format to interface with its client. This feature that .NET provides holds the key in the context of a MES development and implementation. The aim of this applied research is to design a MES using VS.NET to control the working of a Flexible Manufacturing System (FMS) namely CAMCELL. The architecture used for the MES will then be gauged against an MES implementation done previously using a Siemens\u27 PC-based automation technology and Visual FoxPro. This study will integrate the Siemens\u27 technology with the .NET framework to enhance the resulting MES efficiency. The shop floor details or the real-time data collection will be done using the databases from WinCC and data aggregation and manipulation will be done within the .NET framework. The software architecture used for this study will achieve vertical integration between the CAMCELL ERP layer, the MES layer and the Control layer. The study will demonstrate how the data stored in a high level ERP database can be converted into useful information for the control layer for process control and also how real-time information gathered from the control layer can be filtered into useful information up to the ERP layer to facilitate the decision making process. VS.NET user interface screens will be proposed to support these activities. The performance of the proposed architecture will be compared to that from previous studies, thus benchmarking VS.NET for the implementation of the MES

The Online dating romance scam: The psychological impact on victims – both financial and non-financial

This paper examined the psychological impact of the online dating romance scam. Unlike other mass-marketing fraud victims, these victims experienced a ‘double hit’ of the scam: a financial loss and the loss of a relationship. For most, the loss of the relationship was more upsetting than their financial losses (many described the loss of the relationship as a ‘death’). Some described their experience as traumatic and all were affected negatively by the crime. Most victims had not found ways to cope given the lack of understanding from family and friends. Denial (e.g., not accepting the scam was real or not being able to separate the fake identity with the criminal) was identified as an ineffective means of coping, leaving the victim vulnerable to a second wave of the scam. Suggestions are made as to how to change policy with regards to law enforcement deal with this crime

The level of origin firing inversely affects the rate of replication fork progression

DNA damage slows DNA synthesis at replication forks; however, the mechanisms remain unclear. Cdc7 kinase is required for replication origin activation, is a target of the intra-S checkpoint, and is implicated in the response to replication fork stress. Remarkably, we found that replication forks proceed more rapidly in cells lacking Cdc7 function than in wild-type cells. We traced this effect to reduced origin firing, which results in fewer replication forks and a consequent decrease in Rad53 checkpoint signaling. Depletion of Orc1, which acts in origin firing differently than Cdc7, had similar effects as Cdc7 depletion, consistent with decreased origin firing being the source of these defects. In contrast, mec1-100 cells, which initiate excess origins and also are deficient in checkpoint activation, showed slower fork progression, suggesting the number of active forks influences their rate, perhaps as a result of competition for limiting factors

Is lumbar facet joint tropism developmental or secondary to degeneration? An international, large-scale multicenter study by the AOSpine Asia Pacific Research Collaboration Consortium

published_or_final_versio

Rotation of nilotinib and imatinib for first-line treatment of chronic phase chronic myeloid leukemia.

he introduction of second-generation tyrosine-kinase inhibitors (TKIs) has generated a lively debate on the choice of first-line TKI in chronic phase, chronic myeloid leukemia (CML). Despite the TKIs have different efficacy and toxicity profiles, the planned use of two TKIs has never been investigated. We report on a phase 2 study that was designed to evaluate efficacy and safety of a treatment alternating nilotinib and imatinib, in newly diagnosed BCR-ABL1 positive, chronic phase, CML patients. One hundred twenty-three patients were enrolled. Median age was 56 years. The probabilities of achieving a complete cytogenetic response, a major molecular response, and a deep molecular response (MR 4.0) by 2 years were 93%, 87%, and 61%, respectively. The 5-year overall survival and progression-free survival were 89%. Response rates and survival are in the range of those reported with nilotinib alone. Moreover, we observed a relatively low rate of cardiovascular adverse events (5%). These data show that the different efficacy and toxicity profiles of TKIs could be favorably exploited by alternating their us

Polymers for Delivering a Substance into a Cell

Disclosed herein are polymers that can be made cationic and used to deliver a substance into a cell. Also disclosed are pharmaceutical compositions comprising the polymers and methods of using the polymers