The nature of 1WGA J1958.2+3232: a new intermediate polar

We present low and intermediate resolution spectroscopy of the optical counterpart to the recently discovered pulsating X-ray source 1WGA J1958.2+3232. The presence of strong HI , HeI and HeII emission lines together with the absence of absorption features rules out the possibility that the object is a massive star, as had recently been suggested. The observed X-ray and optical characteristics are consistent with the object being an intermediate polar. The double-peaked structure of the emission lines indicates that an accretion disc is present

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking

We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells. N-Acetyllactosamine-containing glycans, known as galectin ligands, were found enriched in detergent-resistant membranes. Here, we analyzed the potential contribution of N-and/ or O-glycans in this mechanism. Structural studies were carried out on the brush border membrane-enriched fraction using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and nano-ESI-QTOF-MS/MS. The pattern of N-glycans was very heterogeneous, with the presence of high mannose- and hybrid-type glycans as well as a multitude of complex-type glycans. In contrast, the pattern of O-glycans was very simple with the presence of two major core type 1 O-glycans, sialylated and bisialylated T-antigen structures {[}Neu5Ac alpha 2-3Gal beta 1-3GalNAc-ol and Neu5Ac alpha 2-3Gal beta 1 -3(Neu5Ac alpha 2-6)GalNAc-ol]. Thus, N-glycans rather than O-glycans contain the N-acetyllactosamine recognition signals for the lipid raft-based galectin-4-dependent apical delivery. In the presence of 1-deoxymannojirimycin, a drug which inhibits the generation of hybrid-type or complex type N-glycans, the extensively O-glycosylated mucin-like MUC1 glycoprotein was not delivered to the apical brush border but accumulated inside the cells. Altogether, our data demonstrate the crucial role of complex N-glycans in the galectin-4-dependent delivery of glycoproteins to the apical brush border membrane of enterocytic HT-29 cells

Monolithic integration of Giant Magnetoresistance (GMR) devices onto standard processed CMOS dies

Giant Magnetoresistance (GMR) based technology is nowadays the preferred option for low magnetic fields sensing in disciplines such as biotechnology or microelectronics. Their compatibility with standard CMOS processes is currently investigated as a key point for the development of novel applications, requiring compact electronic readout. In this paper, such compatibility has been experimentally studied with two particular non-dedicated CMOS standards: 0.35 μm from AMS (Austria MicroSystems) and 2.5 μm from CNM (Centre Nacional de Microelectrònica, Barcelona) as representative examples. GMR test devices have been designed and fabricated onto processed chips from both technologies. In order to evaluate so obtained devices, an extended characterization has been carried out including DC magnetic measurements and noise analysis. Moreover, a 2D-FEM (Finite Element Method) model, including the dependence of the GMR device resistance with the magnetic field, has been also developed and simulated. Its potential use as electric current sensors at the integrated circuit level has also been demonstrated

Compact and explicit physical model for lateral metal-oxide-semiconductor field-effect transistor with nanoelectromechanical system based resonant gate

We propose a simple analytical model of a metal-oxide-semiconductor field-effect transistor with a lateral resonant gate based on the coupled electromechanical equations, which are self-consistently solved in time. All charge densities according to the mechanical oscillations are evaluated. The only input parameters are the physical characteristics of the device. No extra mathematical parameters are used to fit the experimental results. Theoretical results are in good agreement with the experimental data in static and dynamic operation. Our model is comprehensive and may be suitable for any electromechanical device based on the field-effect transduction

XMM-Newton observation of the persistent Be/NS X-ray binary pulsar RX J1037.5-5647 in a low luminosity state

The spectra of several X-ray binary pulsars display a clear soft excess, which in most cases can be described with a blackbody model, above the main power-law component. While in the high-luminosity sources it is usually characterized by low temperature (kT 100 km), in the two persistent and low-luminosity pulsars 4U 0352+309 and RX J0146.9+6121 this component has a high temperature (kT > 1 keV) and a smaller radius (R < 0.5 km), consistent with the estimated size of the neutron-star polar cap. Here we report on the timing and spectral analysis of RX J1037.5-5647, another low-luminosity persistent Be binary pulsar, based on the first XMM-Newton observation of this source. We have found a best-fit period P = 853.4(+/-0.2) s, that implies an average pulsar spin-up dP/dt ~ -2E-8 s/s in the latest decade. The estimated source luminosity is Lx ~ 10^34 erg/s, a value comparable to that of the other persistent Be binary pulsars and about one order of magnitude lower than in most of the previous measurements. The source spectrum can be described with a power law plus blackbody model, with kTbb = 1.26(+0.16/-0.09) keV and Rbb = 128(+13/-21) m, suggesting a polar-cap origin of this component. These results strengthen the hypothesis that, in addition to low luminosities and long periods, this class of sources is characterized also by common spectral propertiesComment: 9 pages, 8 figures, 2 tables. Accepted for publication by Astronomy and Astrophysic

INTEGRAL long-term monitoring of the Supergiant Fast X-ray Transient XTE J1739-302

In the past few years, a new class of High Mass X-Ray Binaries (HMXRB) has been claimed to exist, the Supergiant Fast X-ray Transients (SFXT). These are X-ray binary systems with a compact companion orbiting a supergiant star which show very short and bright outbursts in a series of activity periods overimposed on longer quiescent periods. Only very recently the first attempts to model the behaviour of these sources have been published, some of them within the framework of accretion from clumpy stellar winds.Our goal is to analyze the properties of XTE J1739-302/IGR J17391-3021 within the context of the clumpy structure of the supergiant wind. We have used INTEGRAL and RXTE/PCA observations in order to obtain broad band (1-200 keV) spectra and light curves of XTE J1739-302 and investigate its X-ray spectrum and temporal variability. We have found that XTE J1739-302 follows a much more complex behaviour than expected. Far from presenting a regular variability pattern, XTE J1739-302 shows periods of high, intermediate, and low flaring activity.Comment: 9 pages, 7 figures, accepted for publication in A&

First observations of the X-ray transient EXO 2030+375 with IBIS/ISGRI

We present a first INTEGRAL observation of the 42s transient X-ray pulsar EXO 2030+375 with IBIS/ISGRI. The source was detected during Cyg X-1 observations in December 2002. We analyzed observations during the outburst period from 9 to 21 December 2002 with a total exposure time of ~770 kiloseconds. EXO 2030+375 was almost always detected during single ~30 minute exposures in the 18-45 energy bands. The source light curve shows the characteristic outburst shape observed in this source.Comment: 4 pages, 3 figures (1 in CMYK color), accepted by Astronomy and Astrophysics, INTEGRAL special issue, 200

Correlated Timing and Spectral Variations of the Soft X-ray Transient Aquila X-1: Evidence for an Atoll classification

Based on Rossi X-ray Timing Explorer data, we discuss the classification of the soft X-ray transient Aquila X-1 in the Z/atoll scheme, and the relation of its kilohertz quasi-periodic oscillations (kHz QPO) properties to the X-ray colors. The color-color diagram shows one elongated ("banana") structure and several "islands" of data points. The power spectra of the island are best represented by a broken power-law, whereas those of the banana by a power-law below ~ 1 Hz plus an exponentially cut-off component at intermediate frequencies (30-60 Hz). The parameters of these two components change in correlation with the position of the source in the color-color diagram. Based on the pattern that the source shows in the color-color diagram and its aperiodic variability we conclude that Aquila X-1 is an atoll source. We have also investigated the possible correlation between the frequency of the kHz QPO and the position of the source in the color-color diagram. The complexity seen in the frequency versus count rate diagram is reduced to a single track when the frequency is plotted against hard or soft color.Comment: 9 pages, 5 figures. Accepted for publication in Ap