Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation.

Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients

The role of electron-hole recombination in organic magnetoresistance

Magneto-electrical measurements were performed on diodes and bulk heterojunction solar cells (BHSCs) to clarify the role of formation of coulombically bound electron-hole (e-h) pairs on the magnetoresistance (MR) response in organic thin film devices. BHSCs are suitable model systems because they effectively quench excitons but the probability of forming e-h pairs in them can be tuned over orders of magnitude by the choice of material and solvent in the blend. We have systematically varied the e-h recombination coefficients, which are directly proportional to the probability for the charge carriers to meet in space, and found that a reduced probability of electrons and holes meeting in space lead to disappearance of the MR. Our results clearly show that MR is a direct consequence of e-h pair formation. We also found that the MR line shape follows a power law-dependence of B0.5 at higher fields

Minimal Stability in Maximal Supergravity

Recently, it has been shown that maximal supergravity allows for non-supersymmetric AdS critical points that are perturbatively stable. We investigate this phenomenon of stability without supersymmetry from the sGoldstino point of view. In particular, we calculate the projection of the mass matrix onto the sGoldstino directions, and derive the necessary conditions for stability. Indeed we find a narrow window allowing for stable SUSY breaking points. As a by-product of our analysis, we find that it seems impossible to perturb supersymmetric critical points into non-supersymmetric ones: there is a minimal amount of SUSY breaking in maximal supergravity.Comment: 27 pages, 1 figure. v2: two typos corrected, published versio

Effects of heavy modes on vacuum stability in supersymmetric theories

We study the effects induced by heavy fields on the masses of light fields in supersymmetric theories, under the assumption that the heavy mass scale is much higher than the supersymmetry breaking scale. We show that the square-masses of light scalar fields can get two different types of significant corrections when a heavy multiplet is integrated out. The first is an indirect level-repulsion effect, which may arise from heavy chiral multiplets and is always negative. The second is a direct coupling contribution, which may arise from heavy vector multiplets and can have any sign. We then apply these results to the sGoldstino mass and study the implications for the vacuum metastability condition. We find that the correction from heavy chiral multiplets is always negative and tends to compromise vacuum metastability, whereas the contribution from heavy vector multiplets is always positive and tends on the contrary to reinforce it. These two effects are controlled respectively by Yukawa couplings and gauge charges, which mix one heavy and two light fields respectively in the superpotential and the Kahler potential. Finally we also comment on similar effects induced in soft scalar masses when the heavy multiplets couple both to the visible and the hidden sector.Comment: LaTex, 24 pages, no figures; v2 some comments and references adde

A no-go for no-go theorems prohibiting cosmic acceleration in extra dimensional models

A four-dimensional effective theory that arises as the low-energy limit of some extra-dimensional model is constrained by the higher dimensional Einstein equations. Steinhardt & Wesley use this to show that accelerated expansion in our four large dimensions can only be transient in a large class of Kaluza-Klein models that satisfy the (higher dimensional) null energy condition [1]. We point out that these no-go theorems are based on a rather ad-hoc assumption on the metric, without which no strong statements can be made.Comment: 20 page

Scalar geometry and masses in Calabi-Yau string models

We study the geometry of the scalar manifolds emerging in the no-scale sector of Kahler moduli and matter fields in generic Calabi-Yau string compactifications, and describe its implications on scalar masses. We consider both heterotic and orientifold models and compare their characteristics. We start from a general formula for the Kahler potential as a function of the topological compactification data and study the structure of the curvature tensor. We then determine the conditions for the space to be symmetric and show that whenever this is the case the heterotic and the orientifold models give the same scalar manifold. We finally study the structure of scalar masses in this type of geometries, assuming that a generic superpotential triggers spontaneous supersymmetry breaking. We show in particular that their behavior crucially depends on the parameters controlling the departure of the geometry from the coset situation. We first investigate the average sGoldstino mass in the hidden sector and its sign, and study the implications on vacuum metastability and the mass of the lightest scalar. We next examine the soft scalar masses in the visible sector and their flavor structure, and study the possibility of realizing a mild form of sequestering relying on a global symmetry.Comment: 36 pages, no figure

Metastable de Sitter vacua in N=2 to N=1 truncated supergravity

We study the possibility of achieving metastable de Sitter vacua in general N=2 to N=1 truncated supergravities without vector multiplets, and compare with the situations arising in N=2 theories with only hypermultiplets and N=1 theories with only chiral multiplets. In N=2 theories based on a quaternionic manifold and a graviphoton gauging, de Sitter vacua are necessarily unstable, as a result of the peculiar properties of the geometry. In N=1 theories based on a Kahler manifold and a superpotential, de Sitter vacua can instead be metastable provided the geometry satisfies some constraint and the superpotential can be freely adjusted. In N=2 to N=1 truncations, the crucial requirement is then that the tachyon of the mother theory be projected out from the daughter theory, so that the original unstable vacuum is projected to a metastable vacuum. We study the circumstances under which this may happen and derive general constraints for metastability on the geometry and the gauging. We then study in full detail the simplest case of quaternionic manifolds of dimension four with at least one isometry, for which there exists a general parametrization, and study two types of truncations defining Kahler submanifolds of dimension two. As an application, we finally discuss the case of the universal hypermultiplet of N=2 superstrings and its truncations to the dilaton chiral multiplet of N=1 superstrings. We argue that de Sitter vacua in such theories are necessarily unstable in weakly coupled situations, while they can in principle be metastable in strongly coupled regimes.Comment: 40 pages, no figure

Instantons on Quivers and Orientifolds

We compute the prepotential for gauge theories descending from ${\cal N}=4$ SYM via quiver projections and mass deformations. This accounts for gauge theories with product gauge groups and bifundamental matter. The case of massive orientifold gauge theories with gauge group SO/Sp is also described. In the case with no gravitational corrections the results are shown to be in agreement with Seiberg-Witten analysis and previous results in the literature.Comment: 28 pages, revised version, references added, some typos correcte

Moduli stabilization with Fayet-Iliopoulos uplift

In the recent years, phenomenological models of moduli stabilization were proposed, where the dynamics of the stabilization is essentially supersymmetric, whereas an O'Rafearthaigh supersymmetry breaking sector is responsible for the "uplift" of the cosmological constant to zero. We investigate the case where the uplift is provided by a Fayet-Iliopoulos sector. We find that in this case the modulus contribution to supersymmetry breaking is larger than in the previous models. A first consequence of this class of constructions is for gauginos, which are heavier compared to previous models. In some of our explicit examples, due to a non-standard gauge-mediation type negative contribution to scalars masses, the whole superpartner spectrum can be efficiently compressed at low-energy. This provides an original phenomenology testable at the LHC, in particular sleptons are generically heavier than the squarks.Comment: 29 pages, 2 figure

Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab

<p>Objective To determine serum biomarker associations with clinical response to golimumab treatment in patients with psoriatic arthritis (PsA).</p> <p>Methods GO–REVEAL was a randomised, placebo-controlled study of golimumab in patients with active PsA. Samples were collected from 100 patients at baseline, week 4 and week 14, and analysed for serum-based biomarkers and protein profiling (total 92 markers); data were correlated with clinical measures at week 14.</p> <p>Results Serum levels of a subset of proteins (apolipoprotein C III, ENRAGE, IL-16, myeloperoxidase, vascular endothelial growth factor, pyridinoline, matrix metalloproteinase 3, C-reactive protein (CRP), carcinoembryonic antigen, intercellular adhesion molecule 1 and macrophage inflammatory protein 1α) at baseline or week 4 were strongly associated with American College of Rheumatology 20% improvement (ACR20) response and/or disease activity score in 28 joints (DAS28) at week 14. A smaller subset of proteins was significantly associated with a 75% improvement in the psoriasis area and severity index score (PASI75) at week 14, (adiponectin, apolipoprotein CIII, serum glutamic oxaloacetic transaminase, and tumour necrosis factor α). Subsets of proteins were identified as potentially predictive of clinical response for each of the clinical measures, and the power of these biomarker panels to predict clinical response to golimumab treatment was stronger than for CRP alone.</p> <p>Conclusions This analysis provides insight into several panels of markers that may have utility in identifying PsA patients likely to have ACR20, DAS28, or PASI75 responses following golimumab treatment.</p&gt