Higher Order Two Step Mechanisms in Nucleon Antinucleon Annihilation and the OZI Rule

We evaluate three meson doorway mechanisms for nucleon-antinucleon annihilation at rest for the first time. Detailed results are presented for the final state phi pi0 originating from the 3S1 initial state and for the phi rho channel originating from 1S0. The results presented also include the improved contributions from two meson doorway states and from the tree diagrams. For all the channels considered a consistent explanation of large and small OZI violations emerges.Comment: 18 pages, 2 PostScript figures, will be published in Eur. Phys. J.

Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries

Latent tuberculosis infection (LTBI) is characterised by the presence of immune responses to previously acquired Mycobacterium tuberculosis infection without clinical evidence of active tuberculosis (TB). Here we report evidence-based guidelines from the World Health Organization for a public health approach to the management of LTBI in high risk individuals in countries with high or middle upper income and TB incidence of <100 per 100 000 per year. The guidelines strongly recommend systematic testing and treatment of LTBI in people living with HIV, adult and child contacts of pulmonary TB cases, patients initiating anti-tumour necrosis factor treatment, patients receiving dialysis, patients preparing for organ or haematological transplantation, and patients with silicosis. In prisoners, healthcare workers, immigrants from high TB burden countries, homeless persons and illicit drug users, systematic testing and treatment of LTBI is conditionally recommended, according to TB epidemiology and resource availability. Either commercial interferon-gamma release assays or Mantoux tuberculin skin testing could be used to test for LTBI. Chest radiography should be performed before LTBI treatment to rule out active TB disease. Recommended treatment regimens for LTBI include: 6 or 9 month isoniazid; 12 week rifapentine plus isoniazid; 3–4 month isoniazid plus rifampicin; or 3–4 month rifampicin alone

Diarilpropanos y derivado indolico en madera de virola sebifera y virola calophylloidea

De la madera de Virola sebifera fueron aislados tres díarilpropanos: 1-(4'-hidroxi-2'-metoxifenil-3-(3"-hidrox¡-4"-metoxifenil)-propano, Virolanol B y Virolanol C. De la madera de Virola calophylloidea fue aislado el 3-¡ndolcarboxaldehido

Lignanos en hojas de virola sebifera

De las hojas de Virola sebifera fueron aislados tres lignanos furofuránicos: (+ )-sesamina, (+ )-kobusina y (-t- )-eudesmina. Se describe una adaptación de la técnica de cromatografía liquida al vacío

Non-indigenous partner perspectives on indigenous peoples' involvement in renewable energy: exploring reconciliation as relationships of accountability or status quo innocence?

This is the author accepted manuscript. The final version is available from Emerald via the DOI in this record This research considers the potential for renewable energy partnerships to contribute to Canada's efforts to overcome its colonial past and present by developing an understanding of how non-Indigenous peoples working in the sector relate to their Indigenous partners. Design/methodology/approach This study is part of a larger research program focused on decolonization and reconciliation in the renewable energy sector. This exploratory research is framed by energy justice and decolonial reconciliation literatures relevant to the topic of Indigenous-led renewable energy. The authors used content and discourse analysis to identify themes arising from 10 semi-structured interviews with non-Indigenous corporate and governmental partners. Findings Interviewees’ lack of prior exposure to Indigenous histories, cultures and acknowledgement of settler colonialism had a profound impact on their engagement with reconciliation frameworks. Partners' perspectives on what it means to partner with Indigenous peoples varied; most dismissed the need to further develop understandings of reconciliation and instead focused on increasing community capacity to allow Indigenous groups to participate in the renewable energy transition. Research limitations/implications In this study, the authors intentionally spoke with non-Indigenous peoples working in the renewable energy sector. Recruitment was a challenge and the sample is small. The authors encourage researchers to extend their questions to other organizations in the renewable energy sector, across industries and with Indigenous peoples given this is an under-researched field. Originality/value This paper is an early look at the way non-Indigenous “partners” working in renewable energy understand and relate to topics of reconciliation, Indigenous rights and self-determination. It highlights potential barriers to reconciliation that are naïvely occurring at organizational and institutional levels, while anchored in colonial power structures.Canadian Institutes for Health Researc

Sex-Specific Cardiovascular Risks of Cancer and Its Therapies

In both cardiovascular disease and cancer, there are established sex-based differences in prevalence and outcomes. Males and females may also differ in terms of risk of cardiotoxicity following cancer therapy, including heart failure, cardiomyopathy, atherosclerosis, thromboembolism, arrhythmias, and myocarditis. Here, we describe sex-based differences in the epidemiology and pathophysiology of cardiotoxicity associated with anthracyclines, hematopoietic stem cell transplant (HCT), hormone therapy and immune therapy. Relative to males, the risk of anthracycline-induced cardiotoxicity is higher in prepubertal females, lower in premenopausal females, and similar in postmenopausal females. For autologous hematopoietic cell transplant, several studies suggest an increased risk of late heart failure in female lymphoma patients, but sex-based differences have not been shown for allogeneic hematopoietic cell transplant. Hormone therapies including GnRH (gonadotropin-releasing hormone) modulators, androgen receptor antagonists, selective estrogen receptor modulators, and aromatase inhibitors are associated with cardiotoxicity, including arrhythmia and venous thromboembolism. However, sex-based differences have not yet been elucidated. Evaluation of sex differences in cardiotoxicity related to immune therapy is limited, in part, due to low participation of females in relevant clinical trials. However, some studies suggest that females are at increased risk of immune checkpoint inhibitor myocarditis, although this has not been consistently demonstrated. For each of the aforementioned cancer therapies, we consider sex-based differences according to cardiotoxicity management. We identify knowledge gaps to guide future mechanistic and prospective clinical studies. Furthering our understanding of sex-based differences in cancer therapy cardiotoxicity can advance the development of targeted preventive and therapeutic cardioprotective strategies

Validação do sub-modelo de simulação de crescimento de forrageiras do IFSM (Integrated Farm System Model), com dados de Cynodon spp.

Um sub-modelo representando o crescimento e o acúmulo de matéria seca em um modelo de simulação de fazenda desenvolvido para as condições de clima temperado está sendo estendido para forrageiras tropicais. Na validação do sub-modelo foram utilizados dados de um ensaio com Cynodon spp. submetido a níveis crescentes de adubo nitrogenado. Embora as predições no período das águas mostraram-se sub-estimadas, os resultados confirmaram a consistência do sub-modelo e indicaram a sua sensibilidade a mudanças nos valores de alguns parâmetros críticos que necessitam de calibração e geração de dados locais