A COMPARATIVE ASSESSMENT OF PHARMACOLOGICALLY ACTIVE PRINCIPLES AND ANTIOXIDANT ACTIVITY OF COMMONLY OCCURRING MUCUNA SPS. IN INDIA

The genus Mucuna (Fabaceae) includes about 150 species and almost all the species are reported to contain L-3,4-dihydroxy phenylalanine (L-Dopa), a non-protein amino acid that acts as precursor for the neurotransmitter dopamine, used in the treatment of Parkinsons disease. The present study was aimed to assess the pharmacologically active principles and antioxidant activities of Mucuna pruriens (L.) DC., Mucuna bracteata DC., Mucuna cochinchinensis (Lour.) A. Chev. black seeds sp. and Mucuna cochinchinensis (Lour.) A. Chev. white seeds sp. The aqueous extract of plant material was subjected to assess the pharmacologically active principles by using L-dopa quantification, determination of protein and flavonoids, total phenolic content, Inhibition of DPPH radical and Reducing power/Ferric reducing antioxidant potential (FRAP) assays. The results obtained showed that, Mucuna cochinchinensis black seeds sp. has highest protein, total phenolic content, L-dopa content and DPPH radical scavenging activity. Mucuna bracteata seeds showed highest flavonoid content whereas, in FRAP assay Mucuna pruriens extract showed highest potential to reduce the ferric ions. It can be concluded from this study that, L-DOPA possesses antioxidant activity which was supported by in-vitro antioxidant assays. This indicates that the antioxidant activity of the aqueous extracts of all the Mucuna sps. may be due to the presence of L-Dopa content in its seed

Synthesis and structures of thieno[2,3-b]thiophene incorporated [3.3]dithiacyclophanes. Enhanced first hyperpolarizability in an unsymmetrically polarized cyclophane

Dithiacyclophanes incorporating thieno[2,3-b]thiophene have been synthesized. in order to investigate the nonlinear optical properties of donor-acceptor cyclophane 7. Cyclophane 7 displayed significantly higher first hyperpolarizability beta (21.6 x 10(-30) esu) compared to model 10 (9.58 x 10(-30) esu). Relatively higher in 7 presumably arises from an extra electron redistribution arising from through-space charge transfer, a feature lacking in 10. Moreover. the thermal decomposition temperature of 7 (300 degrees C) is higher than that reported for the NLO prototype DAN (295 degrees C). (c) 2006 Elsevier Ltd. All rights reserved

Kinetics and Mechanism of Formation of 2,3-Disubstituted 1,4-Benzothiazines: One Pot DMSO Assisted Cyclocondensation of Bisanilino Disulphide and 1, 3-Dicarbonyls

The kinetics of DMSO (dimethylsulphoxide) assisted one pot cyclocondensation of bisanilino disulphide and 1,3-dicarbonyls has been investigated using spectral method. The kinetic measurements have been carried by varying media, temperature and concentration of the reactants. The assistance of DMSO is investigated. The order of reaction, effects of substituents with dicarbonyls on the rates and thermodynamic parameters has also been reported. First time reaction conditions are optimised for performing the cyclocondensation conveniently and rapidly. Probably mechanism has been proposed and order of reaction was determined on the basis of rate expression and was in agreement with second order rate equation, used for the determination of rate constants.</jats:p

CCDC 297140: Experimental Crystal Structure Determination

Related Article: S.H.Mashraqui, Y.S.Sangvikar, A.Meetsma|2006|Tetrahedron Lett.|47|5599|doi:10.1016/j.tetlet.2006.05.098,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

CCDC 297141: Experimental Crystal Structure Determination

Related Article: S.H.Mashraqui, Y.S.Sangvikar, A.Meetsma|2006|Tetrahedron Lett.|47|5599|doi:10.1016/j.tetlet.2006.05.098,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

CCDC 297142: Experimental Crystal Structure Determination

Related Article: S.H.Mashraqui, Y.S.Sangvikar, A.Meetsma|2006|Tetrahedron Lett.|47|5599|doi:10.1016/j.tetlet.2006.05.098,Related Article: S.H.Mashraqui, Y.S.Sangvikar, S.G.Ghadigaonkar, M.Ashraf, M.Meetsma|2008|Tetrahedron|64|8837|doi:10.1016/j.tet.2008.06.076,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Oxa-bridged cyclophanes featuring thieno[2,3-b]thiophene and C-2-symmetric binol or bis-naphthol rings:synthesis, structures, and conformational studies

Oxa-bridged cyclophanes 4/6 and 8/10 featuring thieno[2,3-b]thiophene ring and binol or bis-naphthol have been synthesized. The Structures are assigned by 2D NMR data and the identity of 4 is also independently established by a single X-ray crystallography. From dynamic NMR analysis, the Arrhenius energy of activation Delta G(#) for bridge inversions in 4 and 6 was calculated to be 15.3 and 12.9 kcal/mol, respectively. A higher Delta G(#) for 4, relative to the ester free 6 is attributable to the steric compression stemming from C2/C5 ester substituents to the bridge inversion processes. While the methylene bridges undergo inversion in 4 and 6, the naphthyl-naphthyl pseudo-rotation appears to be restricted even at higher temperatures. This is Supported by retention of the optical purity of the chiral (-) 4 under thermal condition. For the case of bis-naphthol cyclophane 8, we observed the flipping of both the -OCH2- and the naphthyl-CH2-naphthyl bridges with Delta G(#) of ca. 11.4 kcal/mol. However, the ester free cyclophane 10 remained conformationally mobile even at -55 degrees C and its AGO was assumed to b