131 research outputs found
Application of a two-dimensional parabolic computer program to prediction of turbulent reacting flows
The capabilities of a computer program are explored, and computed results are compared with data. The comparisons are restricted to two-dimensional flows. Subsonic and supersonic flows, ducted and nonducted, reacting and nonreacting, are considered. An evaluation of models used for turbulence and chemical reaction was included. Constants in the dissipation rate of turbulent kinetic energy, turbulence model, which produces mixing in good agreement with data, are the same for all calculations. Experimental data are reported for coaxial injection at matched pressure (1 atm or 101.3 kPa) of a cold, Mach 2, hydrogen jet into a hot, Mach 2, vitiated airstream. Profiles of pitot pressure and gas composition obtained from water cooled probes are reported and compared with theoretical results
2019 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations : summary from the basic life support; advanced life support; pediatric life support; neonatal life support; education, implementation, and teams; and first aid task forces
The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research
2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
This focused update to the American Heart Association guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care follows the Pediatric Task Force of the International Liaison Committee on Resuscitation evidence review. It aligns with the International Liaison Committee on Resuscitation's continuous evidence review process, and updates are published when the International Liaison Committee on Resuscitation completes a literature review based on new science. This update provides the evidence review and treatment recommendation for chest compression-only CPR versus CPR using chest compressions with rescue breaths for children <18 years of age. Four large database studies were available for review, including 2 published after the "2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care." Two demonstrated worse 30-day outcomes with chest compression-only CPR for children 1 through 18 years of age, whereas 2 studies documented no difference between chest compression-only CPR and CPR using chest compressions with rescue breaths. When the results were analyzed for infants <1 year of age, CPR using chest compressions with rescue breaths was better than no CPR but was no different from chest compression-only CPR in 1 study, whereas another study observed no differences among chest compression-only CPR, CPR using chest compressions with rescue breaths, and no CPR. CPR using chest compressions with rescue breaths should be provided for infants and children in cardiac arrest. If bystanders are unwilling or unable to deliver rescue breaths, we recommend that rescuers provide chest compressions for infants and children
In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs)
2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19
In April 2020, the American Heart Association (AHA) Emergency Cardiovascular Care (ECC) Committee and Get With The Guidelines-Resuscitation Adult and Pediatric Task Forces published their Interim Guidance for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed Coronavirus Disease 2019 (COVID-19) at the start of the SARS-CoV-2 pandemic. In October 2020, the AHA published new cardiopulmonary resuscitation (CPR) guidelines with the latest evidence-based algorithms and recommendations for Basic Life Support, Advanced Cardiac Life Support, Pediatric Advanced Life Support, Neonatal Advanced Life Support, and Maternal Cardiac Arrest Resuscitation
2018 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary
The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the second annual summary of International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations that includes the most recent cardiopulmonary resuscitation science reviewed by the International Liaison Committee on Resuscitation. This summary addresses the role of antiarrhythmic drugs in adults and children and includes the Advanced Life Support Task Force and Pediatric Task Force consensus statements, which summarize the most recent published evidence and an assessment of the quality of the evidence based on Grading of Recommendations, Assessment, Development, and Evaluation criteria. The statements include consensus treatment recommendations approved by members of the relevant task forces. Insights into the deliberations of each task force are provided in the Values and Preferences and Task Force Insights sections. Finally, the task force members have listed the top knowledge gaps for further research
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Predicting social impacts associated with roadway development in a scenic area
The issue of predicting social impacts that could result from the construction and use of new roadways is one that faces, or will face, many communities in the U.S. and throughout the world. Where road development takes place in a scenic area, especially one that is dependent on tourist trade, the nature of the secondary land conversion that often accompanies road construction is especially important. We have assessed the social impacts likely to accompany construction of a scenic parkway in a rural area abutting the Great Smoky Mountains National Park. In this paper, we share the substantive findings of that study as well as our methodological observations on the challenges of projecting impacts in an area that has no planning or zoning, a situation that is common to many rural areas. We also discuss how we dealt with the fact that the major effects of the project would not begin until nearly 15 years in the future, when construction is completed and the roadway is opened to traffic. In order to predict land use patterns at the completion of roadway construction, we studied plat maps, which accurately reflect changing ownership patterns before such changes become apparent on the ground. We also conducted interviews with local realtors and developers who, in the absence of a local government planning department, tend to be the best sources of information concerning local land use trends. Uncertainty of future events was accounted for by projecting impacts for different scenarios, reflecting varying rates of growth and types of development. We believe that the description of our methodological approach should prove helpful to other analysts faced with the need to predict long-term transformations without the benefit of existing land use plans. In our assessment, we examined potential effects to local population, housing, land use, public services, taxes, economic structure, cultural resources, and social structure. Our findings are discussed briefly in this paper
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