Sikap Pemustaka Terhadap Layanan Sirkulasi Berbasis Slims Di Perpustakaan Unika De La Salle Manado

The purpose of this study was to determine the attitude towards service users based Slims circulation in the library Unika De La Salle Manado. Which is measured by looking at the attitudes of users of the five components of the service, namely circulation, circulation service itself, librarians, collections, regulations, and facilities. The method used is descriptive research method with a total sample of 64 people from the overall population of existing users of the library Unika De La Salle Manado.The results showed that users were generally satisfied with the process of circulation in library services based computerized Slims. So clearly seen the positive impact of the integration of information technology in circulation in the library service. Good judgment for services also directly proportional to the assessment of the librarians who work in the circulation. Users showed a good attitude for librarians, in this case about how the appearance and the services provided by librarians themselves.User attitudes towards existing collection addressed feeling less satisfied because of incomplete and not up to date, so that sometimes users can not find the collection is sought. To rule on the service life of the user circulation rate was well defined and appropriate.One contributing factor that can not be ignored that facility. In this case, as the library has been based Slims, Library Unika De La Salle Manado is required to provide supporting facilities such as computers and internet services. Despite having been supplied, it turns out according to user numbers are still lacking and can not operate properly, so it takes an increase to give a good impression to the user.Thus, it is recommended to librarians in the library Unika De La Salle Manado, there should be an increase in the quality of service in terms of the librarian, then the collection as well as supporting the existing facilities, is intended to provide maximum service to users who visit the library Unika De La Salle Manado

The Efficient Synthesis of 2-Arylamino-2-imidazolines, 2-Heteroaryl- Substituted Benzimidazoles, and Their Morpholin-4-ylmethyl Derivatives

2-Heteroaryl-substituted 1H-benzimidazoles were synthesized in good yields by heating the HSO3 adducts of heteroaromatic aldehydes with o-phenylenediamine in DMF under reflux. This procedure is more general and shorter than earlier methods. 2-Arylamino-2-imidazolines were prepared by heating dimethyl aryldithioimidocarbonates and ethylenediamine under reflux. The imine-enamine tautomerization of 2-arylamino-2-imidazolines was investigated by means of 1H-NMR spectroscopy. Morpholin-4-ylmethyl derivatives of the benzimidazole and imidazoline products were synthesized regioselectively by treatment with morpholine and formaldehyde. South African Journal of Chemistry Vol.55 2002: 119-123PDF and Supplemetry file attache

Early and long-term outlook of percutaneous coronary intervention for bifurcation lesions in young patients

Coronary artery disease is most common in older patients, but may occur in younger subjects. The outlook of young patients after percutaneous coronary intervention (PCI) of challenging lesion subsets such as coronary bifurcations, is not established. We thus aimed to appraise the early and long-term results of PCI for bifurcations in young patients

PURA syndrome : clinical delineation and genotype-phenotype study in 32 individuals with review of published literature

Background De novo mutations in PURA have recently been described to cause PURA syndrome, a neurodevelopmental disorder characterised by severe intellectual disability (ID), epilepsy, feeding difficulties and neonatal hypotonia. Objectives T o delineate the clinical spectrum of PURA syndrome and study genotype-phenotype correlations. Methods Diagnostic or research-based exome or Sanger sequencing was performed in individuals with ID. We systematically collected clinical and mutation data on newly ascertained PURA syndrome individuals, evaluated data of previously reported individuals and performed a computational analysis of photographs. We classified mutations based on predicted effect using 3D in silico models of crystal structures of Drosophila-derived Pur-alpha homologues. Finally, we explored genotypephenotype correlations by analysis of both recurrent mutations as well as mutation classes. Results We report mutations in PURA (purine-rich element binding protein A) in 32 individuals, the largest cohort described so far. Evaluation of clinical data, including 22 previously published cases, revealed that all have moderate to severe ID and neonatal-onset symptoms, including hypotonia (96%), respiratory problems (57%), feeding difficulties (77%), exaggerated startle response (44%), hypersomnolence (66%) and hypothermia (35%). Epilepsy (54%) and gastrointestinal (69%), ophthalmological (51%) and endocrine problems (42%) were observed frequently. Computational analysis of facial photographs showed subtle facial dysmorphism. No strong genotype-phenotype correlation was identified by subgrouping mutations into functional classes. Conclusion We delineate the clinical spectrum of PURA syndrome with the identification of 32 additional individuals. The identification of one individual through targeted Sanger sequencing points towards the clinical recognisability of the syndrome. Genotype-phenotype analysis showed no significant correlation between mutation classes and disease severity.Peer reviewe

Fifteen years trends of cardiogenic shock and mortality in patients with diabetes and acute coronary syndromes

PURPOSE: Our study was intended to examine time trends of management and mortality of acute coronary syndrome patients with associated diabetes mellitus. METHODS: We analyzed data from 5 nationwide registries established between 2001 and 2014, including consecutive acute coronary syndrome patients admitted to the Italian Intensive Cardiac Care Units. RESULTS: Of 28,225 participants, 8521 (30.2%) had diabetes: as compared with patients without diabetes, they were older and had significantly higher rates of prior myocardial infarction and comorbidities (all P < .0001). Prevalence of diabetes and comorbidities increased over time (P for trend < .0001). Cardiogenic shock rates were higher in patients with diabetes, as compared with those without diabetes (7.8% vs 2.8%, P < .0001), and decreased significantly over time only in patients without diabetes (P = .007). Revascularization rates increased over time in patients both with and without diabetes (both P for trend < .0001), although with persistingly lower rates in patients with diabetes. All-cause in-hospital mortality was higher in patients with diabetes (5.4 vs 2.5%, respectively, P < .0001) and decreased more consistently in patients without diabetes (P for trend = .007 and < .0001, respectively). At multivariable analysis, diabetes remains an independent predictor of both cardiogenic shock (odds ratio 2.03; 95% confidence interval, 1.77-2.32; P < .0001) and mortality (odds ratio 1.95; 95% confidence interval, 1.69-2.26; P < .0001). CONCLUSIONS: Despite significant mortality reductions observed over 15 years in acute coronary syndromes, patients with diabetes continue to show threefold higher rates of cardiogenic shock and lower revascularization rates as compared with patients without diabetes. These findings may explain the persistingly higher mortality of patients with diabetes and acute coronary syndromes