Dose-dependent Pupicidal, Adulticidal and Ovicidal Activities of Leaf Extracts of Tiliacora Acuminata on Japanese Encephalitis Vector Culex Vishnui Group

Vector of Japanese encephalitis is Culex vishnui group of mosquito and control of that mosquito is facing threat due to emergence of resistance to synthetic insecticides. Insecticides of plant origin now act as suitable alternate for control of JE vector. To investigate dose-dependent pupicidal, adulticidal and ovicidal activities, crude and acetone extracts of leaf of Tiliacora acuminata were used against Cx. vishnui group of mosquito. In case of dose-dependent pupicidal activity, highest mortality observed at 1.5% concentration of crude extract and 75 ppm of acetone extract with 45.67% and 67.67% mortality respectively after 36 h of exposure followed by 24h and 12h. In case of adulticidal activity, highest mortality in crude extract was observed at 2.5% concentration with 73% of adult mosquitoes were dead, but in acetone extract at 120 ppm concentration shows nearly about 67% mortality of adult mosquitoes after 24 h of exposure. While in ovicidal activity at 0.5% crude extract have 11.67% egg hatching so nearly about 88.33% ovicidal activity takes place at this concentration. In acetone extract, there was nearly about 93.33% ovicidal activities at 55 ppm concentration. So leaf extracts of T. acuminata may be used as better pupicidal, adulticidal and ovicidal plant origin insecticide for control of Cx. vishnui group of mosquito. Further research is required to isolate and characterize the active principle of T. acuminata plant leaf extract

Functional gene analysis suggests different acetogen populations in the Bovine Rumen and Tammar Wallaby Forestomach

Reductive acetogenesis via the acetyl coenzyme A (acetyl-CoA) pathway is an alternative hydrogen sink to methanogenesis in the rumen. Functional gene-based analysis is the ideal approach for investigating organisms capable of this metabolism (acetogens). However, existing tools targeting the formyltetrahydrofolate synthetase gene (fhs) are compromised by lack of specificity due to the involvement of formyltetrahydrofolate synthetase (FTHFS) in other pathways. Acetyl-CoA synthase (ACS) is unique to the acetyl-CoA pathway and, in the present study, acetyl-CoA synthase genes (acsB) were recovered from a range of acetogens to facilitate the design of acsB-specific PCR primers. fhs and acsB libraries were used to examine acetogen diversity in the bovine rumen and forestomach of the tammar wallaby (Macropus eugenii), a native Australian marsupial demonstrating foregut fermentation analogous to rumen fermentation but resulting in lower methane emissions. Novel, deduced amino acid sequences of acsB and fhs affiliated with the Lachnospiraceae in both ecosystems and the Ruminococcaeae/Blautia group in the rumen. FTHFS sequences that probably originated from nonacetogens were identified by low "homoacetogen similarity" scores based on analysis of FTHFS residues, and comprised a large proportion of FTHFS sequences from the tammar wallaby forestomach. A diversity of FTHFS and ACS sequences in both ecosystems clustered between the Lachnospiraceae and Clostridiaceae acetogens but without close sequences from cultured isolates. These sequences probably originated from novel acetogens. The community structures of the acsB and fhs libraries from the rumen and the tammar wallaby forestomach were different (LIBSHUFF, P < 0.001), and these differences may have significance for overall hydrogenotrophy in both ecosystems

Proportion, Risk Factors and the Impact of Dysmenorrhea among Girls

Background: Dysmenorrhea is the leading cause of recurrent short-term school absence in adolescent girls and a common problem in women of reproductive age. There are many factors related to this disorder which include a younger age, low body mass index (BMI), smoking, early menarche, and prolonged menstrual flow. Objectives: (1) To find the proportion of dysmenorrhea among girls of a nursing college; (2) To find out the risk factors and impact of dysmenorrhea.Materials and Methods: A cross-sectional study was conducted from November 2011 to April 2012 at Nursing College, VIMS, Bellary, Karnataka. Data were collected by a pre-tested and pre-designed semi-structured pro forma. The study was performed on a total of 196 students who agreed to participate and present at the time of study. Analysis was done by using Epi-info version 3.4.3.Results: The average age of the study group was 19.3+1.8 years (range 17–30). Proportion of dysmenorrhea was found to be 77% and was significantly higher in females with positive family history of dysmenorrhea when compared to the others (P<0.05), who had early age of menarche, irregular cycle, increased amount of flow, gynecological problems and lack exercise had high rate of dysmenorrhea compared to others but statistically it was not significant. In this study, because of dysmenorrhea 20.5% had class absenteeism, 23.2% college absenteeism, 44.4% had poor concentration, 31.8% were depressed, 53% were irritable and 2.6% had suicidal tendencies.Conclusion and Recommendation: There was a high proportion of dysmenorrhea and also girls were very much worried about it. There is a need to educate them about causes, treatment and also to cope with stress at the time of menstrual cycle

Circulation characteristics of a monsoon depression during BOBMEX-99 using high-resolution analysis

The skill and efficiency of a numerical model mostly varies with the quality of initial values, accuracy on parameterization of physical processes and horizontal and vertical resolution of the model. Commonly used low-resolution reanalyses are hardly able to capture the prominent features associated with organized convective processes in a monsoon depression. The objective is to prepare improved high-resolution analysis by the use of MM5 modelling system developed by the Pennsylvania State University/National Center for Atmospheric Research (PSU/NCAR). It requires the objective comparison of high and low-resolution analysis datasets in assessing the specific convective features of a monsoon depression. For this purpose, reanalysis datasets of NCAR/NCEP (National Center for Atmospheric Research/National Centers for Environmental Prediction) at a horizontal resolution of 2.5° (latitude/longitude) have been used as first guess in the objective analysis scheme. The additional asynoptic datasets obtained during BOBMEX-99 are utilized within the assimilation process. Cloud Motion Wind (CMW) data of METEOSAT satellite and SSM/I surface wind data are included for the improvement of derived analysis. The multiquadric (MQD) interpolation technique is selected and applied for meteorological objective analysis at a horizontal resolution of 30 km. After a successful inclusion of additional data, the resulting reanalysis is able to produce the structure of convective organization as well as prominent synoptic features associated with monsoon depression. Comparison and error verifications have been done with the help of available upper-air station data. The objective verification reveals the efficiency of the analysis scheme

Impact of vegetation on the simulation of seasonal monsoon rainfall over the Indian subcontinent using a regional model

The change in the type of vegetation fraction can induce major changes in the local effects such as local evaporation, surface radiation, etc., that in turn induces changes in the model simulated outputs. The present study deals with the effects of vegetation in climate modeling over the Indian region using the MM5 mesoscale model. The main objective of the present study is to investigate the impact of vegetation dataset derived from SPOT satellite by ISRO (Indian Space Research Organization) versus that of USGS (United States Geological Survey) vegetation dataset on the simulation of the Indian summer monsoon. The present study has been conducted for five monsoon seasons (1998-2002), giving emphasis over the two contrasting southwest monsoon seasons of 1998 (normal) and 2002 (deficient). The study reveals mixed results on the impact of vegetation datasets generated by ISRO and USGS on the simulations of the monsoon. Results indicate that the ISRO data has a positive impact on the simulations of the monsoon over northeastern India and along the western coast. The MM5-USGS has greater tendency of overestimation of rainfall. It has higher standard deviation indicating that it induces a dispersive effect on the rainfall simulation. Among the five years of study, it is seen that the RMSE of July and JJAS (June-July-August-September) for All India Rainfall is mostly lower for MM5-ISRO. Also, the bias of July and JJAS rainfall is mostly closer to unity for MM5-ISRO. The wind fields at 850 hPa and 200 hPa are also better simulated by MM5 using ISRO vegetation. The synoptic features like Somali jet and Tibetan anticyclone are simulated closer to the verification analysis by ISRO vegetation. The 2 m air temperature is also better simulated by ISRO vegetation over the northeastern India, showing greater spatial variability over the region. However, the JJAS total rainfall over north India and Deccan coast is better simulated using the USGS vegetation. Sensible heat flux over north-west India is also better simulated by MM5-USGS

Developing a Wireless Network for Optimum Distance Learning Assistant

A new wireless network-based distant education auxiliary system is developed to address the issues of low operational efficiency, slow reaction times, and unstable systems. Develop the hardware component of the system's business process and enhance the functionalities of the subsystems. The subsystem encompasses course information enquiries, administration of instructors and in-person teaching processes, and plan management, among other functions. To enhance the implementation of linked hardware applications, audio and video signals are integrated in software design via the combination of signal coding technologies, using MMX technology for synchronous processing. The testing findings indicate that the developed system may significantly decrease reaction time and enhance stability. This research establishes a robust framework for the steady functioning of a distance education auxiliary methods and achieves the optimisation of a distance education auxiliary systems

Designing a Cartridge Winder with Electronic Control

ABSTRACT There are number of winding machines in the market based on either the Random, Precision, or Step Precision winding system. Filtration application requires a uniform lay of yarn or its performance may be affected, hence, for the aforesaid purpose, the precision system would be more apt. Recent trends show an increased use of electronics in all applications, textiles being no exception. The aim of the present work was to develop a filter cartridge winder (laboratory model) based on the precision winding system, controlled electronically. The novelty of this machine lies in the fact that it makes use of a chain to reciprocate the guide mounted on it, unlike the majority of commercial filter winders, which make use of scroll cams to traverse the yarn. Filter winders are specialized winders that produce cartridges in standard sizes of 10&quot;, 20&quot;, 30&quot; and up to 70&quot;. Thus a cartridge winder is quite different from the usual winding machines not only in terms of its traverse length and feed material but also because of the core tube which has to be perforated just as one required for a dyeing process

Green Growth and Equity in the Context of Climate Change: Some Considerations

Green growth entails several different kinds of processes: conversion to low-carbon energy, climate resilience, and response to climate shocks. Equity implies a fair sharing of the costs, within countries and between countries. The authors set out to explore some of the ways that equity has been considered in climate change discussions. They discuss per capita emission right approaches, and highlight key challenges in the application of equity in global climate change negotiations. They provide a brief overview key approaches to carbon financing, focusing on some recent cost estimations of potential climate change impacts, as well as of projected needs for green growth programs. The diversity of estimates and present evidence on the apparent gulf between available public financing and green growth needs are highlighted; and considerations of implementing green growth, focusing on building climate resilience and responding to climate shocks are discussed. In conclusion, the authors present one approach to a global Green Fund to receive assessed contributions of member countries and disburse grant and loan fund to low-income and middle-income countries to pursue green growth programs

Spectrum of sensitive skin in India: a collaborative expert position statement

IntroductionSensitive skin poses a significant dermatological concern in India, influenced by diverse climatic conditions, cultural practices, and pollution levels. These factors contribute to the prevalence of sensitive skin, which is characterized by symptoms such as redness, itching, and dryness. Sensitive skin is better understood as a distinct syndrome rather than a linear progression from dry skin to conditions like acne, atopic dermatitis, and rosacea. The condition impacts the overall quality of life of affected individuals, making it crucial to understand its spectrum and management.MethodsA panel of 12 dermatologists from various regions of India provided expert insights into the characterization of sensitive skin. The dermatologists discussed the spectrum of sensitive skins and provided strategies for managing the condition. Their recommendations emphasized the importance of individualized skincare regimens tailored to the specific needs of patients.ResultsSeveral studies have discussed the heterogeneity of sensitive skin, indicating the complexity of its diagnosis and management. The market is saturated with a variety of cosmeceuticals aimed at addressing sensitive skin. However, there are no established guidelines for using these products, leading to the adoption of individualized skincare regimens as the most common approach.DiscussionThis expert paper highlights the necessity of recommending cosmeceuticals in managing sensitive skin and emphasizes the importance of personalized skincare regimens. By comprehensively addressing the spectrum of sensitive skin, clinicians can prevent the progression to severe dermatological conditions, thereby safeguarding the skin barrier and improving the overall quality of life for individuals affected by sensitive skin

Priprava i vrednovanje šumećih plutajućih tableta tizanidin hidroklorida

Tizanidine hydrochloride is an orally administered prokinetic agent that facilitates or restores motility throughout the length of the gastrointestinal tract. The objective of the present investigation was to develop effervescent floating matrix tablets of tizanidine hydrochloride for prolongation of gastric residence time in order to overcome its low bioavailability (3440 %) and short biological half life (4.2 h). Tablets were prepared by the direct compression method, using different viscosity grades of hydroxypropyl methylcellulose (HPMC K4M, K15M and K100M). Tablets were evaluated for various physical parameters and floating properties. Further, tablets were studied for in vitro drug release characteristics in 12 hours. Drug release from effervescent floating matrix tablets was sustained over 12 h with buoyant properties. DSC study revealed that there is no drug excipient interaction. Based on the release kinetics, all formulations best fitted the Higuchi, first-order model and non-Fickian as the mechanism of drug release. Optimized formulation (F9) was selected based on the similarity factor (f2) (74.2), dissolution efficiency at 2, 6 and 8 h, and t50 (5.4 h) and was used in radiographic studies by incorporating BaSO4. In vivo X-ray studies in human volunteers showed that the mean gastric residence time was 6.2 ± 0.2 h.Tizanidin hidroklorid je prokinetički agens za peroralnu primjenu koji olakšava ili obnavlja mobilnost kroz gastrointestinalni trakt. Cilj rada bio je razvoj šumećih plutajućih matriksnih tableta tizanidin hidroklorida za produljenje zadržavanja u želucu u svrhu poboljšanja niske bioraspoloživosti (3440 %) i produljenja vremena poluživota (4,2 h). Tablete su pripravljene metodom izravne kompresije, koristeći hidroksipropil metilcelulozu različite viskoznosti (HPMCK4M, K15M i K100M). Određeni su različiti fizikalni parametri. Oslobađanje ljekovite tvari in vitro bilo je polagano tijekom 12 sati, a tablete su imale svojstvo plutanja. Prema DSC ispitivanja nema interakcije s pomoćnim tvarima. Kinetička ispitivanja pokazuju da oslobađanje iz svih pripravaka slijedi Higuchijev model, kinetiku prvog reda i ne-Fickov zakon. Na temelju faktora sličnosti (f2) (74,2), oslobađanja ljekovite tvari nakon 2, 6 i 8 h, te vremena poluživota t50 (5,4 h) izabrana je optimirana formulacija (F9) i upotrebljena u radiografičkim ispitivanjima koja uključuju BaSO4. In vivo ispitivanja rendgenskim zrakama na dobrovoljcima pokazala su da je srednje vrijeme zadržavanja u želucu bilo 6,2 ± 0,2 h