Methodologies for Assessment of Building's Energy Efficiency and Conservation: A Policy-Maker View

Recent global peer-review reports have concluded on importance of buildings in tacking the energy security and climate change challenges. To integrate the buildings energy efficiency into the policy agenda, significant research efforts have been recently done. More specifically, the public domain provides a bulk of literature on the application of buildings-related efficiency technologies and behavioural patterns, barriers to penetration of these practices, policies to overcome these barriers. From the policy-making perspective it is useful to understand how far our understanding of building energy efficiency goes and the approaches and methodologies are behind such assessment

Functional genomics in identification of drug targets in Dupuytren's contracture

Although functional genomics methods offer new viewpoint on molecular processes involved in particular pathological state, these methods, in particular proteomics, are still under-represented in Dupuytren's contracture research. However, several recent papers based on functional genomics technologies represent a breakthrough in studying Dupuytren's contracture as they revealed new molecular players that had been impossible to detect by traditional molecular biology methods. Using computational tools to provide biological context for such broad arrays of data accelerates the process of homing in on the potential molecular markers and drug targets. Interactomes, maps of protein-protein interactions characteristic for the disease and as such putative models of its molecular pathology, are especially useful for this purpose, facilitating the transition from global screening methods to specific experiments aimed at therapy development. The combination of these approaches in Dupuytren's contracture research might therefore facilitate the discovery of novel therapeutic targets and diagnostic markers indicative of disease progression