A Survey on Data control from sender using cloud computing

To store data more efficiently in cloud security must also be taken into considerations. When certain information is stored in Cloud, it actually means that it resides outside an organization's structure bounds. This results in loss of data and information which leads to low cost security issues that, reduces adoption of Cloud computing techniques. This paper surveys mainly on data-centric access control with enriched role-based quality focusing security as a target, protecting user information despite the Cloud service provider that holds it. It also deals with identity based encryption and proxy re-encryption techniques to protect the authorization model

A COMPARATIVE EVALUATION OF ELECTROCARDIOGRAMS RECORDED IN CLASSICAL LIMB AND EXPERIMENTAL METHODS IN NATIVE CATS OF ODISHA, INDIA

The ECG was recorded in the leads I, II, and III by two methods of leads’ positioning: the classical limb method and the experimental method (red electrode at back of the neck, yellow electrode in the sacrum area, green electrode in the area beneath the breastbone and black electrode on the skin fold of the knee joint of the right hind limb). The heart rates were 157.69 (S.E.±5.05) and 134.54 (S.E.±3.08) in classical limb and experimental methods respectively. The mean electrical axis (MEA) shifted from 47.74 (S.E.±3.75) º in the classical limb method to 119.12 (S.E.±0.91) º in the experimental method. The amplitude of P- and R-waves was negative in lead-I only. Since, it is often very difficult to restrain the cats with the electrodes attached to all its limbs, the values obtained in the experimental method could be used as reference values for this alternative way of ECG recording in adult cats

SILVER NANOPARTICLES AND COCONUT OIL INCORPORATED BIOPOLYMER BASED ELECTROSPUN NANOFIBERS FOR WOUND DRESSING

Objective: The main aim of this study was to develop and evaluate the nanofiber loaded with coconut oil and silver nanoparticles (Ag NPs) for the treatment of wound healing by the electrospun method. Methods: The nanofibers have been created using the reduced form of silver nanoparticles and coconut oil along with Eudragit L-100 by the electrospun method. The presence of coconut oil and chemical interaction was determined by the FTIR method. XRD was made to evaluate the crystalline nature of AgNPs and Eudragit L-100. TEM was carried out to show the presence of AgNPs on the surface of nanofibers and SEM represents the diameter of the fiber. The antibacterial activity of nanofibers was carried out using a disk diffusion assay. Results: The diameter of the fibers was diminished by the excess of AgNPs in the fibers, while it increases by the coconut oil concentration, enhancing the nanofiber's hydrophilicity. FTIR spectroscopy was found in the range of coconut oil at 3553 cm-1for O-H stretch, 1365 cm-1, and 1240 cm-1 for the C-O stretch of ester groups. The diffraction peaks at 2θ of 38.5°, 44.6°, and 64.7°, in the XRD spectra of nanofiber, changed with silver NP affirming the total decrease of Ag salt. The bactericidal activity has been carried out between Escherichia coli and Staphylococcus aureus showing zones of inhibition of 20.0±0.2 mm and 14.8±0.4 mm, exhibiting excellent bactericidal characteristics for wound healing. Conclusion: The formulated nanofibers were obtained to offer protection against external agents and help in the regeneration of new tissue

Influence of planting pattern and nutrient management on plant growth, yield and quality of sweet corn in a rainfed sweet corn-cowpea intercropping system

Intercropping, a sustainable agricultural practice, enhances land use efficiency, soil fertility and overall crop productivity. This study uses a split-plot design to evaluate the effects of various Sweet corn (SC) + Cowpea (CP) intercropping patterns and nutrient management strategies on sweet corn growth, yield and quality during 2019 and 2020 cropping years. The hypothesis was that intercropping, combined with optimal nutrient management, can significantly enhance the performance of sweet corn. Amongst the planting pattern and nutrient management practices, sweet corn and cowpea planted in alternate paired rows of 2:2 and 75 % of the soil test based recommended fertilizer (STBFR) to SC and STBFR to CP, supplemented with consortia biofertilizer (BC) gave superior results in terms of growth, yield and yield attributing characters as compared to other treatments. Specifically, SC planting with CP in 1:1 and 2:2 ratios showed a yield increase of 13 % to 15.6 % over the same-row planting. Although the planting pattern did not significantly influence the quality parameters of SC, the nutrient management practice involving 75 % STBFR with BC resulted in the highest accumulation of total sugars (10.8 %), reducing sugars (1.98 %), non-reducing sugars (8.55 %) protein content (8.69 %), total soluble solids (TSS) value (15.79 °Brix), phenol content (0.19 %) and calcium content (42.73 mg) in the kernels. The study suggested that intercropping sweet corn and cowpea in a 2:2 row pattern, combined with 75 % STBFR to SC + STBFR to CP + BC, is a sustainable and economically beneficial practice for farmers

Synthesis and Evaluation of Eight- and Four-membered Iminosugar Analogues as Inhibitors of Testicular Ceramide-specific Glucosyltransferase, Testicular β-Glucosidase 2, and other Glycosidases

Eight- and four-membered analogues of N-butyldeoxynojirimycin (NB-DNJ), a reversible male contraceptive in mice, were prepared and tested. A chiral pool approach was used for the synthesis of the target compounds. Key steps for the synthesis of the eight-membered analogues involve: ringclosing metathesis and Sharpless asymmetric dihydroxylation, and for the four-membered analogues: Sharpless epoxidation, epoxide ring opening (azide), and Mitsunobu reaction to form the four-membered ring. (3S,4R,5S,6R,7R)-1-Nonylazocane-3,4,5,6,7-pentaol (6), was moderately active against rat-derived ceramide-specific glucosyltransferase and four of the other eight-membered analogues were weakly active against rat-derived β-glucosidase 2. Among the four-membered analogues, ((2R,3s,4S)-3-hydroxy-1-nonylazetidine-2,4-diyl)dimethanol (25), displayed selective inhibitory activity against mouse-derived ceramide-specific glucosyltransferase and was about half as potent as NB-DNJ against the rat-derived enzyme. ((2S,4S)-3-Hydroxy-1-nonyl-azetidine-2,4-diyl)dimethanol (27) was found to be a selective inhibitor of β-glucosidase 2, with potency similar to NB-DNJ. Additional glycosidase assays were performed to identify potential other therapeutic applications. The eight-membered iminosugars exhibited specificity for almond-derived β-glucosidase and the 1-nonylazetidine 25 inhibited α-glucosidase (Saccharomyces cerevisiae) with an IC50 of 600 nM and β-glucosidase (almond) with an IC50 of 20 µM. Only N-nonyl derivatives were active, emphasizing the importance of a long lipophilic side chain for inhibitory activity of the analogues studied

Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin

Hyperferritinemia is associated with poor outcomes in critically ill patients with sepsis, hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndromes (MAS) and coronavirus disease 19 (COVID-19). Autopsies of hyperferritinemic patients that succumbed to either sepsis, HLH, MAS or COVID-19 have revealed disseminated microvascular thromboses with von Willebrand factor (VWF)-, platelets-, and/or fibrin-rich microthrombi. It is unknown whether high plasma ferritin concentration actively promotes microvascular thrombosis, or merely serves as a prognostic biomarker in these patients. Here, we show that secretion of VWF from human umbilical vein endothelial cells (HUVEC) is significantly enhanced by 100,000 ng/ml of recombinant ferritin heavy chain protein (FHC). Ferritin fraction that was isolated by size exclusion chromatography from the plasma of critically ill HLH patients promoted VWF secretion from HUVEC, compared to similar fraction from non-critically ill control plasma. Furthermore, recombinant FHC moderately suppressed the activity of VWF cleaving metalloprotease ADAMTS-13. These observations suggest that a state of marked hyperferritinemia could promote thrombosis and organ injury by inducing endothelial VWF secretion and reducing the ADAMTS-13 activity

THE MANAGEMENT OF PRIMARY DYSMENORRHOEA (KASHTARTAVA) - A PROSPECTIVE MULTICENTRIC OPEN OBSERVATIONAL STUDY

Objective: To evaluate the clinical usefulness of Rajahpravartini vati in the management of primary dysmenorrhoea (Kashtartava) and changes in the quality of life of the subjects. Study design: A multi-centric prospective single arm observational study. Setting and participants: 359 subjects aged between 16 - 35 years suffering from painful menstruation at least for three consecutive regular menstrual cycles were included in the study. Intervention: Rajahpravartini Vati a classical Ayurvedic formulation was administered 250 mg b.d. with lukewarm water for 90 days followed by subsequent 90 days without intervention. Outcome measures: The management of menstrual pain assessing by 10 points Visual Analogue Scale and improvement in the quality of life using SF-36 (RAND) questionnaire. Results: The mean VAS score of pain at baseline was 6.94±1.98, decreasing to 1.7±2.22 at 90th day which further decreased and maintained to 1.24±1.9 up to 180th day. Associated symptoms like nausea, vomiting, constipation, giddiness, breast tenderness, diarrhea, headache and fainting were completely relieved. The improvements of quality of life in 8 domains viz. pain, general health, physical functioning, social functioning, emotional wellbeing, energy/fatigue, limitation due to physical health and emotional problems at the end of 90th day of intervention was also significant (p<0.001) in comparison to baseline. No adverse event occurred during the treatment period. Conclusion: Rajahpravartini Vati has shown a positive role for the treatment of dysmenorrhoea and to improve the quality of life of the subjects