भारतातील आणि महाराष्ट्रातील पिंजऱ्यातील मत्स्यपैदास : सद्य आणि भविष्यातील प्रगतीच्या संधी

Sea farming is a popular area of aquaculture practice throughout the world. In Asian countries, it is rapidly growing to meet the increasing demand of high value marine fishes. Although India has a tradition of aquaculture, sea farming ventures on commercial scale were lacking. In this context, Central Marine Fisheries Research Institute started open sea floating cage culture activities in 2006-07 with Department of Animal Husbandry, Dairying and Fisheries (DAHD&F), Government of India assistance. Indigenous cage of 15 m diameter was fabricated following Norwegian open sea floating cage design and launched at Visakhapatnam. There was a technical setback with the design of cage, and consultation with Indian Institute of Technology, West Bengal helped to overcome technical issues with the cage structure. Open sea floating cage diameter was reduced to 6 m and 14 new open sea floating cages were launched at Sutrapada (Gujarat), Vasai (Maharashtra), Mangalore (Karnataka), Cochin (Kerala), Pulicat (Tamil Nadu), Nellore, Kakinada, Baruva (Andhra Pradesh) and Balasore (Odisha) in participation with National Fisheries Development Board (NFDB)

Assessment of biogeochemical processes of Ashtamudi Lake ecosystem in relation to clam fishery

The Ashtamudi Lake ecosystem in Kerala (southwest coast of India) is well known for its clam resources. This estuarine system contributes approximately 80% of the total clam export trade of India besides providing livelihoods for at least 3,000 local people. Among bivalves, clams are an important source of meat for human consumption while its shells are used in the cement industry

A QbD-based stability-indicating RP-HPLC method for larotrectinib: degradation kinetics and integrated white, green, and blue analytical assessment

Background: Larotrectinib, a selective TRK inhibitor, received FDA approval on April 10, 2025, for treating solid tumors with NTRK gene fusions. Despite its therapeutic significance, no RP-HPLC method using a Quality-by-Design (QbD) framework has been reported. This study aimed to develop and validate a QbD-based RP-HPLC method for larotrectinib estimation. Methodology: Critical Analytical Parameters (CAPs) were identified using a Plackett–Burman Design and optimized via a Central Composite Design (CCD). Separation was achieved on a Sunfire C18 column (250 × 4.6 mm, 5 µm) with a mobile phase of 0.1% OPA and acetonitrile (70:30, v/v), flow rate 1.0 mL/min, injection volume 10 µL, and detection at 262 nm. Optimized conditions from the Method Operable Design Region (MODR) gave a desirability value of 1. Results and Discussion: The method achieved sharp separation with a retention time of 2.2 min in a 5-minute runtime. Validation per ICH Q2(R1) confirmed linearity (12.5–75 µg/mL, R² = 0.9998), intra- and inter-day precision (%RSD < 2%), mean recovery of 99.29%, and sensitivity with DL 0.30 µg/mL and QL 0.92 µg/mL. Forced degradation studies revealed zero-order kinetics under 0.1 N HCl, 0.5 N NaOH, and thermal stress, and first-order kinetics under 0.5 N HCl, 0.1N NaOH, 3% and 5% H₂O₂, and water. Greenness, blueness, whiteness, and sustainability were assessed using AMGS, AGREE, ComplexMoGAPI, BAGI, RGB, and EVG tools, yielding favourable outcomes. Conclusion: The developed QbD-based RP-HPLC method is robust, validated, and stability-indicating, suitable for quality control, regulatory submissions, and bioanalysis of larotrectinib

Stability indicating method development and validation for the determination of haloperidol and benzhexol by RP-HPLC

A simple, Accurate, precise method was developed for the simultaneous estimation of the Haloperidol and Benzhexol in Tablet dosage form. The chromatogram was run through Kromasil (250mm 4.6mm, 5µ). Mobile phase containing Buffer and Acetonitrile and methanol in the ratio of 48:52 was pumped through column at a flow rate of 1.0 ml/min. The temperature was maintained at 30°C. The optimized wavelength for Haloperidol and Benzhexol was 220nm. The retention time of Haloperidol and Benzhexol were found to be 2.415 min and 2.820min. %RSD of the Haloperidol and Benzhexol were and found to be 0.6 and 0.2 respectively. %Recover was Obtained as 98.92% and 99.60% for Haloperidol and Benzhexol. LOD, LOQ values were obtained from regression equations of Haloperidol and Benzhexol were 0.42ppm, 1.27ppm and 0.04ppm, 0.14ppm respectively. Regression equation of Haloperidol is y = 24009x + 38704, and of Benzhexol is y = 40558x + 2880. Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industrie

Design, Performance, and Calibration of the CMS Hadron-Outer Calorimeter

The CMS hadron calorimeter is a sampling calorimeter with brass absorber and plastic scintillator tiles with wavelength shifting fibres for carrying the light to the readout device. The barrel hadron calorimeter is complemented with an outer calorimeter to ensure high energy shower containment in the calorimeter. Fabrication, testing and calibration of the outer hadron calorimeter are carried out keeping in mind its importance in the energy measurement of jets in view of linearity and resolution. It will provide a net improvement in missing \et measurements at LHC energies. The outer hadron calorimeter will also be used for the muon trigger in coincidence with other muon chambers in CMS

Occurrence of cystoisosporosis among domestic cats in Thrissur district, Kerala

This study was aimed to evaluate the prevalence of cystoisosporosis among domestic cats in Thrissur district, Kerala. A total of 155 cats were included in this study. Faecal samples collected from all the cats were subjected examination by direct smear method and floatation by Sheather’s sugar solution. Of 155 faecal samples examined, oocysts were found in 28 cats (18.06 per cent). Among these, 12 were collected from cats with signs of gastrointestinal diseases and 16 from cats which are apparently healthy with firm faeces. Mixed infection with Cystoisospora spp and Toxocara, Ancylostoma and Cystoisospora were also detected in three (1.94 per cent) and one (0.65 per cent) cat respectively. Various risk factors associated with the infection were also studied. Prevalence was found to be higher in cats less than six months old. Gender and breed were not affected the prevalence. This study demonstrates that cystoisosporosis is common in cats

Mass envenomation during Ganesh idol immersion at Girgaum-Chowpathy beach, Mumbai, Maharashtra

At the end of South-West monsoon along Mumbai coast a swarm of the box jelly fish, Chiropsoides buitendijki was observed during Ganesh idol immersion at Girgaum-Chowpathy beach, Mumbai on 10th September, 2013. The occurrence of such large number of jelly fishes coincided with Ganesh idol immersion, perhaps for the first time in Mumbai waters. Several devotees of Ganesh who congregated at Girgaum-Chowpathy beach for immersion ritual of Ganesh idol were stung by the jelly fish. According to the news paper reports, the devotees moved with the idol in ankledeep water for immersion and immediately thin tentacle-like threads pierced legs and ankles causing severe burning sensation

Cage culture in maharashtra: present and future prospects

Sea farming is a popular area of aquaculture practice throughout the world. In Asian countries, it is rapidly growing to meet the increasing demand of high value marine fishes. Although India has a tradition of aquaculture, sea farming ventures on commercial scale were lacking. In this context, Central Marine Fisheries Research Institute started open sea floating cage culture activities in 2006-07 with Department of Animal Husbandry, Dairying and Fisheries (DAHD&F), Government of India assistance. Indigenous cage of 15 m diameter was fabricated following Norwegian open sea floating cage design and launched at Visakhapatnam. There was a technical setback with the design of cage, and consultation with Indian Institute of Technology, West Bengal helped to overcome technical issues with the cage structure. Open sea floating cage diameter was reduced to 6 m and 14 new open sea floating cages were launched at Sutrapada (Gujarat), Vasai (Maharashtra), Mangalore (Karnataka), Cochin (Kerala), Pulicat (Tamil Nadu), Nellore, Kakinada, Baruva (Andhra Pradesh) and Balasore (Odisha) in participation with National Fisheries Development Board (NFDB)